Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases

Ankur Sharma, Dhruv Kumar, Kajal Dahiya, Susan Hawthorne, Saurabh Jha, Niraj Jha, Parma Nand, Samuel Girgis, Sibi Raj, Rashi Srivastava, Vineet Goswani, Yiota Gregoriou, Sally El-Zahaby, Shreesh Ojha, Harish Dureja, Gaurav Gupta, Sachin Singh, Dinesh Chellappan, Kamal Dua

Research output: Contribution to journalReview articlepeer-review

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Abstract

The increasing burden of respiratory diseases caused by microbial infections poses an immense threat to global health. This review focuses on the various types of biofilms that affect the respiratory system and cause pulmonary infections, specifically bacterial biofilms. The article also sheds light on the current strategies employed for the treatment of such pulmonary infection-causing biofilms. The potential of nanocarriers as an effective treatment modality for pulmonary infections is discussed, along with the challenges faced during treatment and the measures that may be implemented to overcome these. Understanding the primary approaches of treatment against biofilm infection and applications of drug-delivery systems that employ nanoparticle-based approaches in the disruption of biofilms are of utmost interest which may guide scientists to explore the vistas of biofilm research while determining suitable treatment modalities for pulmonary respiratory infections.
Original languageEnglish
Pages (from-to)1905-1923
Number of pages19
JournalNANOMEDICINE
Volume16
Issue number21
Early online date5 Aug 2021
DOIs
Publication statusPublished - Sep 2021

Keywords

  • bacterial biofilm
  • biofilm
  • drug delivery
  • nanocarriers
  • pulmonary infection
  • systemic therapy

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