Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study

N Simonsen, P van't Veer, JJ Strain, JM Martin-Moreno, JK Huttunen, JFC Navajas, BC Martin, M Thamm, AFM Kardinaal, FJ Kok, L Kohlmeier

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Abstract

The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast cancer and that the degree of inhibition depends on background levels of omega-6 polyunsaturates. Considered in isolation, the level of omega-3 or omega-8 fat in adipose tissue displayed little consistent association with breast cancer across study centers, The ratio of long-chain omega-3 fatty acids to total omega-6 fat showed an inverse association with breast cancer in four of five centers. In Malaga, Spain, the odds ratio for the highest tertile relative to the lowest reached 0.32 (95% confidence interval 0.13-0.82), In this center, total omega-6 fatty acid was strongly associated with breast cancer, With all centers pooled, the odds ratio for long-chain omega-3 to total omega-8 reached 0.80 for the second tertile and 0.65 for the third tertile, a downward trend bordering on statistical significance (p for trend = 0.055), While not definitive, these results provide evidence for the hypothesis that the balance between omega-3 and omega-8 fat may play a role in breast cancer.
LanguageEnglish
Pages342-352
JournalAmerican Journal of Epidemiology
Volume147
Issue number4
Publication statusPublished - Feb 1998

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Omega-6 Fatty Acids
Adipose Tissue
Breast Neoplasms
Fats
Omega-3 Fatty Acids
Odds Ratio
European Union
Spain
Multicenter Studies
Fatty Acids
Antioxidants
Myocardial Infarction
Confidence Intervals

Cite this

Simonsen, N., van't Veer, P., Strain, JJ., Martin-Moreno, JM., Huttunen, JK., Navajas, JFC., ... Kohlmeier, L. (1998). Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. American Journal of Epidemiology, 147(4), 342-352.
Simonsen, N ; van't Veer, P ; Strain, JJ ; Martin-Moreno, JM ; Huttunen, JK ; Navajas, JFC ; Martin, BC ; Thamm, M ; Kardinaal, AFM ; Kok, FJ ; Kohlmeier, L. / Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. In: American Journal of Epidemiology. 1998 ; Vol. 147, No. 4. pp. 342-352.
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abstract = "The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast cancer and that the degree of inhibition depends on background levels of omega-6 polyunsaturates. Considered in isolation, the level of omega-3 or omega-8 fat in adipose tissue displayed little consistent association with breast cancer across study centers, The ratio of long-chain omega-3 fatty acids to total omega-6 fat showed an inverse association with breast cancer in four of five centers. In Malaga, Spain, the odds ratio for the highest tertile relative to the lowest reached 0.32 (95{\%} confidence interval 0.13-0.82), In this center, total omega-6 fatty acid was strongly associated with breast cancer, With all centers pooled, the odds ratio for long-chain omega-3 to total omega-8 reached 0.80 for the second tertile and 0.65 for the third tertile, a downward trend bordering on statistical significance (p for trend = 0.055), While not definitive, these results provide evidence for the hypothesis that the balance between omega-3 and omega-8 fat may play a role in breast cancer.",
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Simonsen, N, van't Veer, P, Strain, JJ, Martin-Moreno, JM, Huttunen, JK, Navajas, JFC, Martin, BC, Thamm, M, Kardinaal, AFM, Kok, FJ & Kohlmeier, L 1998, 'Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study', American Journal of Epidemiology, vol. 147, no. 4, pp. 342-352.

Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. / Simonsen, N; van't Veer, P; Strain, JJ; Martin-Moreno, JM; Huttunen, JK; Navajas, JFC; Martin, BC; Thamm, M; Kardinaal, AFM; Kok, FJ; Kohlmeier, L.

In: American Journal of Epidemiology, Vol. 147, No. 4, 02.1998, p. 342-352.

Research output: Contribution to journalArticle

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AU - Simonsen, N

AU - van't Veer, P

AU - Strain, JJ

AU - Martin-Moreno, JM

AU - Huttunen, JK

AU - Navajas, JFC

AU - Martin, BC

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AU - Kok, FJ

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AB - The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast cancer and that the degree of inhibition depends on background levels of omega-6 polyunsaturates. Considered in isolation, the level of omega-3 or omega-8 fat in adipose tissue displayed little consistent association with breast cancer across study centers, The ratio of long-chain omega-3 fatty acids to total omega-6 fat showed an inverse association with breast cancer in four of five centers. In Malaga, Spain, the odds ratio for the highest tertile relative to the lowest reached 0.32 (95% confidence interval 0.13-0.82), In this center, total omega-6 fatty acid was strongly associated with breast cancer, With all centers pooled, the odds ratio for long-chain omega-3 to total omega-8 reached 0.80 for the second tertile and 0.65 for the third tertile, a downward trend bordering on statistical significance (p for trend = 0.055), While not definitive, these results provide evidence for the hypothesis that the balance between omega-3 and omega-8 fat may play a role in breast cancer.

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JO - American Journal of Epidemiology

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JF - American Journal of Epidemiology

SN - 0002-9262

IS - 4

ER -

Simonsen N, van't Veer P, Strain JJ, Martin-Moreno JM, Huttunen JK, Navajas JFC et al. Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. American Journal of Epidemiology. 1998 Feb;147(4):342-352.