Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Partrick Bell; Joy Cuthbertson; Steven Patterson; Finbarr O'Harte

doi:10.1016/j.diabres.2010.11.033

Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Partrick Bell
, Joy Cuthbertson
, Steven Patterson
, Finbarr O'Harte

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

Original language	English
Pages (from-to)	E68-E70
Journal	Diabetes Research and Clinical Practice
Volume	91
DOIs	https://doi.org/10.1016/j.diabres.2010.11.033
Publication status	Published (in print/issue) - 1 Mar 2011

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10.1016/j.diabres.2010.11.033

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title = "Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes",

abstract = "We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.",

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AU - Bell, Partrick

AU - Cuthbertson, Joy

AU - Patterson, Steven

AU - O'Harte, Finbarr

PY - 2011/3/1

Y1 - 2011/3/1

N2 - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

AB - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

U2 - 10.1016/j.diabres.2010.11.033

DO - 10.1016/j.diabres.2010.11.033

M3 - Article

SN - 1872-8227

VL - 91

SP - E68-E70

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

ER -

Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Abstract

UN SDGs

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