TY - JOUR
T1 - Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes
AU - Bell, Partrick
AU - Cuthbertson, Joy
AU - Patterson, Steven
AU - O'Harte, Finbarr
PY - 2011/3/1
Y1 - 2011/3/1
N2 - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
AB - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
U2 - 10.1016/j.diabres.2010.11.033
DO - 10.1016/j.diabres.2010.11.033
M3 - Article
SN - 1872-8227
VL - 91
SP - E68-E70
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -
