Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Partrick Bell, Joy Cuthbertson, Steven Patterson, Finbarr O'Harte

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
LanguageEnglish
PagesE68-E70
JournalDiabetes Research and Clinical Practice
Volume91
DOIs
Publication statusPublished - 1 Mar 2011

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nateglinide
Glucagon-Like Peptide 1
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Blood Glucose
Glucose

Cite this

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abstract = "We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.",
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Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes. / Bell, Partrick; Cuthbertson, Joy; Patterson, Steven; O'Harte, Finbarr.

In: Diabetes Research and Clinical Practice, Vol. 91, 01.03.2011, p. E68-E70.

Research output: Contribution to journalArticle

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AB - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

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