Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Partrick Bell, Joy Cuthbertson, Steven Patterson, Finbarr O'Harte

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
Original languageEnglish
Pages (from-to)E68-E70
JournalDiabetes Research and Clinical Practice
Volume91
DOIs
Publication statusPublished - 1 Mar 2011

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