Acute post-ingestion changes in plasma ascorbic acid concentration: Relationship to dose and to existing body stores.

IFF Benzie, JJ Strain

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Plasma ascorbic acid concentrations were measured in 27 adults before and after ingestion of 0.5 - 3.0 g of vitamin C. Mean (SEM) fasting concentration was 64 (3) mu mol/l, with no significant male-female difference. There was a significant correlation between the response and log dose (r = 0.928; P <0.01). There was no significant correlation (r = 0.14; P >0.1) between the dose-corrected increase and the fasting concentration; 0.5 g caused a greater increase than 0.25 g (mean increases 56 and 33 mu mol/l respectively; P <0.01); doses of 1.0 g and 2.0 g did not cause significantly greater responses. Results indicate that i) response to ingestion of vitamin C is dose dependent and independent of body stores of the vitamin, ii) a 0.5g dose appears optimal in terms of increasing the plasma ascorbic acid concentration. Copyright (C) 1997 Elsevier Science Inc.
LanguageEnglish
Pages187-190
JournalNutrition Research
Volume17
Issue number2
Publication statusPublished - Feb 1997

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Ascorbic Acid
Eating
Fasting
Vitamins

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title = "Acute post-ingestion changes in plasma ascorbic acid concentration: Relationship to dose and to existing body stores.",
abstract = "Plasma ascorbic acid concentrations were measured in 27 adults before and after ingestion of 0.5 - 3.0 g of vitamin C. Mean (SEM) fasting concentration was 64 (3) mu mol/l, with no significant male-female difference. There was a significant correlation between the response and log dose (r = 0.928; P <0.01). There was no significant correlation (r = 0.14; P >0.1) between the dose-corrected increase and the fasting concentration; 0.5 g caused a greater increase than 0.25 g (mean increases 56 and 33 mu mol/l respectively; P <0.01); doses of 1.0 g and 2.0 g did not cause significantly greater responses. Results indicate that i) response to ingestion of vitamin C is dose dependent and independent of body stores of the vitamin, ii) a 0.5g dose appears optimal in terms of increasing the plasma ascorbic acid concentration. Copyright (C) 1997 Elsevier Science Inc.",
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Acute post-ingestion changes in plasma ascorbic acid concentration: Relationship to dose and to existing body stores. / Benzie, IFF; Strain, JJ.

Vol. 17, No. 2, 02.1997, p. 187-190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute post-ingestion changes in plasma ascorbic acid concentration: Relationship to dose and to existing body stores.

AU - Benzie, IFF

AU - Strain, JJ

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N2 - Plasma ascorbic acid concentrations were measured in 27 adults before and after ingestion of 0.5 - 3.0 g of vitamin C. Mean (SEM) fasting concentration was 64 (3) mu mol/l, with no significant male-female difference. There was a significant correlation between the response and log dose (r = 0.928; P <0.01). There was no significant correlation (r = 0.14; P >0.1) between the dose-corrected increase and the fasting concentration; 0.5 g caused a greater increase than 0.25 g (mean increases 56 and 33 mu mol/l respectively; P <0.01); doses of 1.0 g and 2.0 g did not cause significantly greater responses. Results indicate that i) response to ingestion of vitamin C is dose dependent and independent of body stores of the vitamin, ii) a 0.5g dose appears optimal in terms of increasing the plasma ascorbic acid concentration. Copyright (C) 1997 Elsevier Science Inc.

AB - Plasma ascorbic acid concentrations were measured in 27 adults before and after ingestion of 0.5 - 3.0 g of vitamin C. Mean (SEM) fasting concentration was 64 (3) mu mol/l, with no significant male-female difference. There was a significant correlation between the response and log dose (r = 0.928; P <0.01). There was no significant correlation (r = 0.14; P >0.1) between the dose-corrected increase and the fasting concentration; 0.5 g caused a greater increase than 0.25 g (mean increases 56 and 33 mu mol/l respectively; P <0.01); doses of 1.0 g and 2.0 g did not cause significantly greater responses. Results indicate that i) response to ingestion of vitamin C is dose dependent and independent of body stores of the vitamin, ii) a 0.5g dose appears optimal in terms of increasing the plasma ascorbic acid concentration. Copyright (C) 1997 Elsevier Science Inc.

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