Acute hyperglycemia and oxidative stress: Direct cause and effect?

Siu-Wai Choi, Iris F. F. Benzie, Shuk-Woon Ma, JJ Strain, BM Hannigan

    Research output: Contribution to journalArticle

    105 Citations (Scopus)

    Abstract

    Oxidative stress is increased in Type 2 diabetes and this appears to underlie the development of diabetic complications. Increased oxidative stress is claimed to be triggered directly by acute (sudden-onset) hyperglycemia, but published data do not clearly support a direct cause and effect relationship. In this article, published evidence of a direct prooxidant effect of acute hyperglycemia is presented and discussed in some detail, and conflicts, controversies, and problems are highlighted. Evidence for glucose variability as a possible important trigger of oxidative stress in diabetes is reviewed, with some speculation as to how the field would be advanced if there were more widespread recognition about the role that wide fluctuations in glucose concentration play in diabetic complications. Possible direct or indirect antioxidative effects of various drugs used in the treatment of diabetic subjects are discussed because these may have influenced current understanding of the link between hyperglycemia and oxidative stress. The aims are to reveal the divergence between the available evidence and the accepted view that acute hyperglycemia is a direct trigger of oxidative stress and to suggest areas of research that will help resolve current controversies in this important and challenging area. (C) 2007 Elsevier Inc. All rights reserved.
    LanguageEnglish
    Pages1217-1231
    JournalFREE RADICAL BIOLOGY AND MEDICINE
    Volume44
    Issue number7
    DOIs
    Publication statusPublished - Apr 2008

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    Hyperglycemia
    Oxidative Stress
    Diabetes Complications
    Glucose
    Type 2 Diabetes Mellitus
    Research
    Pharmaceutical Preparations

    Cite this

    Choi, Siu-Wai ; Benzie, Iris F. F. ; Ma, Shuk-Woon ; Strain, JJ ; Hannigan, BM. / Acute hyperglycemia and oxidative stress: Direct cause and effect?. In: FREE RADICAL BIOLOGY AND MEDICINE. 2008 ; Vol. 44, No. 7. pp. 1217-1231.
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    abstract = "Oxidative stress is increased in Type 2 diabetes and this appears to underlie the development of diabetic complications. Increased oxidative stress is claimed to be triggered directly by acute (sudden-onset) hyperglycemia, but published data do not clearly support a direct cause and effect relationship. In this article, published evidence of a direct prooxidant effect of acute hyperglycemia is presented and discussed in some detail, and conflicts, controversies, and problems are highlighted. Evidence for glucose variability as a possible important trigger of oxidative stress in diabetes is reviewed, with some speculation as to how the field would be advanced if there were more widespread recognition about the role that wide fluctuations in glucose concentration play in diabetic complications. Possible direct or indirect antioxidative effects of various drugs used in the treatment of diabetic subjects are discussed because these may have influenced current understanding of the link between hyperglycemia and oxidative stress. The aims are to reveal the divergence between the available evidence and the accepted view that acute hyperglycemia is a direct trigger of oxidative stress and to suggest areas of research that will help resolve current controversies in this important and challenging area. (C) 2007 Elsevier Inc. All rights reserved.",
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    Acute hyperglycemia and oxidative stress: Direct cause and effect? / Choi, Siu-Wai; Benzie, Iris F. F.; Ma, Shuk-Woon; Strain, JJ; Hannigan, BM.

    In: FREE RADICAL BIOLOGY AND MEDICINE, Vol. 44, No. 7, 04.2008, p. 1217-1231.

    Research output: Contribution to journalArticle

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