Acute exercise and impaired glucose tolerance in obese humans

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65% of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P <0.05). A correlation was observed between PWV and glucose (r = 0.544, P <0.05). There were no changes in LOOHs, SOD, hs-CRP or blood lipids, respectively (P > 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.
LanguageEnglish
Pages262-268
JournalJournal of Clinical Lipidology
Volume3
Issue number4
DOIs
Publication statusPublished - 8 Jul 2009

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Glucose Intolerance
Vascular Stiffness
Exercise
Oxidative Stress
Blood Pressure
Glucose
Pulse Wave Analysis
Lipid Peroxides
C-Reactive Protein
Superoxide Dismutase
Walking
Blood Glucose
Arterial Pressure
Cardiovascular Diseases
Heart Rate
Inflammation
Lipids

Keywords

  • Walking
  • Impaired glucose
  • tolerance
  • Regional stiffness
  • Pulse wave velocity
  • Obesity

Cite this

@article{e655bf280fc0409291c1a729c0709d1a,
title = "Acute exercise and impaired glucose tolerance in obese humans",
abstract = "Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65{\%} of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P <0.05). A correlation was observed between PWV and glucose (r = 0.544, P <0.05). There were no changes in LOOHs, SOD, hs-CRP or blood lipids, respectively (P > 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.",
keywords = "Walking, Impaired glucose, tolerance, Regional stiffness, Pulse wave velocity, Obesity",
author = "Conor McClean and Andrea McNeilly and Trinick, {Tom, R.} and Marie Murphy and Ellie Duly and James McLaughlin and Jane McEneny and George Burke and Gareth Davison",
year = "2009",
month = "7",
day = "8",
doi = "10.1016/j.jacl.2009.07.001",
language = "English",
volume = "3",
pages = "262--268",
journal = "Journal of Clinical Lipidology",
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}

Acute exercise and impaired glucose tolerance in obese humans. / McClean, Conor; McNeilly, Andrea; Trinick, Tom, R.; Murphy, Marie; Duly, Ellie; McLaughlin, James; McEneny, Jane; Burke, George; Davison, Gareth.

In: Journal of Clinical Lipidology, Vol. 3, No. 4, 08.07.2009, p. 262-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute exercise and impaired glucose tolerance in obese humans

AU - McClean, Conor

AU - McNeilly, Andrea

AU - Trinick, Tom, R.

AU - Murphy, Marie

AU - Duly, Ellie

AU - McLaughlin, James

AU - McEneny, Jane

AU - Burke, George

AU - Davison, Gareth

PY - 2009/7/8

Y1 - 2009/7/8

N2 - Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65% of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P <0.05). A correlation was observed between PWV and glucose (r = 0.544, P <0.05). There were no changes in LOOHs, SOD, hs-CRP or blood lipids, respectively (P > 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.

AB - Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65% of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P <0.05). A correlation was observed between PWV and glucose (r = 0.544, P <0.05). There were no changes in LOOHs, SOD, hs-CRP or blood lipids, respectively (P > 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.

KW - Walking

KW - Impaired glucose

KW - tolerance

KW - Regional stiffness

KW - Pulse wave velocity

KW - Obesity

U2 - 10.1016/j.jacl.2009.07.001

DO - 10.1016/j.jacl.2009.07.001

M3 - Article

VL - 3

SP - 262

EP - 268

JO - Journal of Clinical Lipidology

T2 - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

SN - 1933-2874

IS - 4

ER -