Biochemical markers of inflammation are emerging as new predictors of risk of cardiovascular disease (CVD) and may alteracutely with exercise. Few studies have been conducted on the effects of walking on these markers or whether differentwalking intensities elicit varied effects. As there is growing interest in modifiable lifestyle factors such as walking to reduceCVD risk, these inflammatory responses warrant investigation. The aim of this study was to compare the effects of walking at50% versus 70% of predicted maximal heart rate on C-reactive protein (CRP), plasma fibrinogen, and trigylcerides insedentary post-menopausal women. Twelve post-menopausal women (mean age 58 years, s+6; stature 1.62 m, s+0.06;body mass 66.8 kg, s+6.2) completed two 30-min treadmill walks in a randomized cross-over design. Fasted blood sampleswere taken (for the determination of plasma fibrinogen, CRP, and lipids) before, immediately after, and 1 and 24 h afterexercise. Triglyceride concentrations decreased from pre-exercise to 24 h post exercise at both walking intensities(time6group interaction, P50.05). No significant effects were observed for plasma fibrinogen, CRP, total cholesterol, lowdensityor high-density lipoprotein cholesterol (time x group interaction, P40.05). The results of this study suggest thatfasting plasma triglycerides are decreased on the morning after 30 min of brisk walking at either 50% or 70% of maximalheart rate (moderate and vigorous intensity).