Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Louise A. Rollins-Smith; Cynthia Carey; J. Michael Conlon; Laura K. Reinert; Jennifer K. Doersam; Tomas Bergman; Jerzy Silberring; Hilkka Lankinen; David Wade

doi:10.1128/AAC.47.3.1157-1160.2003

Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Louise A. Rollins-Smith
, Cynthia Carey
, J. Michael Conlon
, Laura K. Reinert
, Jennifer K. Doersam
, Tomas Bergman
, Jerzy Silberring
, Hilkka Lankinen
, David Wade

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.

Original language	English
Pages (from-to)	1157-1160
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	3
DOIs	https://doi.org/10.1128/AAC.47.3.1157-1160.2003
Publication status	Published (in print/issue) - 3 Mar 2003

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/AAC.47.3.1157-1160.2003

Cite this

Rollins-Smith, L. A., Carey, C., Conlon, J. M., Reinert, L. K., Doersam, J. K., Bergman, T., Silberring, J., Lankinen, H., & Wade, D. (2003). Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines. Antimicrobial Agents and Chemotherapy, 47(3), 1157-1160. https://doi.org/10.1128/AAC.47.3.1157-1160.2003

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abstract = "Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.",

author = "Rollins-Smith, \{Louise A.\} and Cynthia Carey and Conlon, \{J. Michael\} and Reinert, \{Laura K.\} and Doersam, \{Jennifer K.\} and Tomas Bergman and Jerzy Silberring and Hilkka Lankinen and David Wade",

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doi = "10.1128/AAC.47.3.1157-1160.2003",

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Rollins-Smith, LA, Carey, C, Conlon, JM, Reinert, LK, Doersam, JK, Bergman, T, Silberring, J, Lankinen, H & Wade, D 2003, 'Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines', Antimicrobial Agents and Chemotherapy, vol. 47, no. 3, pp. 1157-1160. https://doi.org/10.1128/AAC.47.3.1157-1160.2003

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T1 - Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

AU - Rollins-Smith, Louise A.

AU - Carey, Cynthia

AU - Conlon, J. Michael

AU - Reinert, Laura K.

AU - Doersam, Jennifer K.

AU - Bergman, Tomas

AU - Silberring, Jerzy

AU - Lankinen, Hilkka

AU - Wade, David

PY - 2003/3/3

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N2 - Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.

AB - Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.

UR - https://www.scopus.com/pages/publications/0037417069

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DO - 10.1128/AAC.47.3.1157-1160.2003

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Abstract

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