TY - JOUR
T1 - Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines
AU - Rollins-Smith, Louise A.
AU - Carey, Cynthia
AU - Conlon, J. Michael
AU - Reinert, Laura K.
AU - Doersam, Jennifer K.
AU - Bergman, Tomas
AU - Silberring, Jerzy
AU - Lankinen, Hilkka
AU - Wade, David
PY - 2003/3/3
Y1 - 2003/3/3
N2 - Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.
AB - Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.
UR - http://www.scopus.com/inward/record.url?scp=0037417069&partnerID=8YFLogxK
U2 - 10.1128/AAC.47.3.1157-1160.2003
DO - 10.1128/AAC.47.3.1157-1160.2003
M3 - Article
C2 - 12604562
AN - SCOPUS:0037417069
SN - 0066-4804
VL - 47
SP - 1157
EP - 1160
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -
