Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

Nigel Irwin; Paula McClean; Steven Patterson; Kerry Hunter; Peter Flatt

doi:10.1515/BC.2009.002

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

Nigel Irwin, Paula McClean, Steven Patterson, Kerry Hunter, Peter Flatt

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Recent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP in ob/ob mice. Initial acute administration of GIP antibody together with oral glucose in ob/ob mice significantly increased the glycaemic excursion compared to controls (p

Original language	English
Pages (from-to)	75-80
Journal	Biological Chemistry
Volume	390
Issue number	1
DOIs	https://doi.org/10.1515/BC.2009.002
Publication status	Published (in print/issue) - Jan 2009

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10.1515/BC.2009.002

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abstract = "Recent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP in ob/ob mice. Initial acute administration of GIP antibody together with oral glucose in ob/ob mice significantly increased the glycaemic excursion compared to controls (p",

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AU - Hunter, Kerry

AU - Flatt, Peter

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Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

Abstract

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