Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

Nigel Irwin, Paula McClean, Steven Patterson, Kerry Hunter, Peter Flatt

Research output: Contribution to journalArticle

29 Citations (Scopus)


Recent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP in ob/ob mice. Initial acute administration of GIP antibody together with oral glucose in ob/ob mice significantly increased the glycaemic excursion compared to controls (p
Original languageEnglish
Pages (from-to)75-80
JournalBiological Chemistry
Issue number1
Publication statusPublished - Jan 2009


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