Abstract
Recent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP in ob/ob mice. Initial acute administration of GIP antibody together with oral glucose in ob/ob mice significantly increased the glycaemic excursion compared to controls (p
Original language | English |
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Pages (from-to) | 75-80 |
Journal | Biological Chemistry |
Volume | 390 |
Issue number | 1 |
DOIs | |
Publication status | Published (in print/issue) - Jan 2009 |