Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

Nigel Irwin, Paula McClean, Steven Patterson, Kerry Hunter, Peter Flatt

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Recent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP in ob/ob mice. Initial acute administration of GIP antibody together with oral glucose in ob/ob mice significantly increased the glycaemic excursion compared to controls (p
LanguageEnglish
Pages75-80
JournalBiological Chemistry
Volume390
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Gastric Inhibitory Polypeptide
Blood Glucose
Vaccination
Animal Models
Obesity
Passive Immunization
Glucose
Antibodies
Research
gastric inhibitory polypeptide receptor

Cite this

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Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. / Irwin, Nigel; McClean, Paula; Patterson, Steven; Hunter, Kerry; Flatt, Peter.

In: Biological Chemistry, Vol. 390, No. 1, 01.2009, p. 75-80.

Research output: Contribution to journalArticle

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