Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus

Katayoon Montazeri; Mohammad Farhadi; Zeinab Akbarnejad; Abdoreza Asadpour; Abbas Majdabadi; Reza Fekrazad; Saeid Mahmoudian

doi:10.1038/s41598-023-39033-5

Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus

Katayoon Montazeri, Mohammad Farhadi, Zeinab Akbarnejad, Abdoreza Asadpour, Abbas Majdabadi, Reza Fekrazad, Saeid Mahmoudian

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Abstract

As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.

Original language	English
Article number	11930 (2023)
Pages (from-to)	1-11
Number of pages	11
Journal	Scientific Reports
Volume	13
Issue number	1
Early online date	24 Jul 2023
DOIs	https://doi.org/10.1038/s41598-023-39033-5
Publication status	Published online - 24 Jul 2023

Bibliographical note

Funding Information:
With gratitude to Iran National Science Foundation (INSF), which funded the laser device, the Grant Code was 91058320. The authors appreciate Iran University of Medical Sciences, research & Technology deputy for funding this work by Ph.D. students’ research program award with the code of 98-2-22-15523. Special thanks to the colleagues of the “Center of Experimental and Comparative of Medical Studies of IUMS”, where the behavioral test was conducted.

Publisher Copyright:
© 2023, The Author(s).

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41598_2023_Article_39033.pdfFinal published version, 1.95 MBLicence: CC BY

Cite this

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title = "Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus",

abstract = "As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.",

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AU - Mahmoudian, Saeid

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N2 - As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.

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Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus

Abstract

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