ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy

Taranjit Singh Rai, Perundurai Subramaniam Dhandapany, Tarunveer Singh Ahluwalia, Monica Bhardwaj, Ajay Bahl, Kewal Krishan Talwar, Krishnakumar Nair, Andiappan Rathinavel, Madhu Khullar

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Abstract

Aim: The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Methods and results: A total of 174 patients diagnosed with cardiomyopathy (118 with HCM, 51 with DCM, and 5 with RCM) and 164 ethnically, age- and gender-matched controls were included in the study. ACE I/D genotyping was performed by PCR. In total, 25.86% of the patients were in New York Heart Association (NYHA) class III and IV at presentation. A total of 67.24% patients had dyspnea, 56.89% had angina pectoris, and 25.28% of the patients had at least one event of syncope. Frequency of occurrence of the disease was more in male patients compared to female patients (P < 0.05). After adjustment for age, sex, body mass index (BMI), and smoking habit, the prevalence of ACE DD genotype, and ACE 'D' allele was significantly higher in patients as compared to controls and was associated with increased risk (DD: OR 2.11, 95% CI 1.27-3.52, P < 0.05; 'D': OR 1.91, 95% CI 1.08-3.35, P < 0.05). The mean septal thickness was higher for DD and ID genotypes (20.40 ± 3.73 mm and 21.82 ± 5.35 mm, respectively) when compared with II genotype (18.63 ± 6.69 mm) in HCM patients, however, the differences were not significant statistically (P > 0.05). The DCM patients with ID genotype showed significantly decreased left ventricular ejection fraction (LVEF) at enrolment (26.50 ± 8.04%) (P = 0.04). Conclusion: Our results suggest thatD allele of ACE I/D polymorphism significantly influences the HCM and DCM phenotypes.

LanguageEnglish
Pages67-72
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume311
Issue number1-2
DOIs
Publication statusPublished - 1 Apr 2008

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Hypertrophic Cardiomyopathy
Dilated Cardiomyopathy
Peptidyl-Dipeptidase A
Polymorphism
Restrictive Cardiomyopathy
Syncope
Angina Pectoris
Cardiomyopathies
Stroke Volume
Dyspnea
Alleles
Genotype
Phenotype
Polymerase Chain Reaction

Keywords

  • ACE I/D polymorphism
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy

Cite this

Rai, Taranjit Singh ; Dhandapany, Perundurai Subramaniam ; Ahluwalia, Tarunveer Singh ; Bhardwaj, Monica ; Bahl, Ajay ; Talwar, Kewal Krishan ; Nair, Krishnakumar ; Rathinavel, Andiappan ; Khullar, Madhu. / ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. In: Molecular and Cellular Biochemistry. 2008 ; Vol. 311, No. 1-2. pp. 67-72.
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title = "ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy",
abstract = "Aim: The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Methods and results: A total of 174 patients diagnosed with cardiomyopathy (118 with HCM, 51 with DCM, and 5 with RCM) and 164 ethnically, age- and gender-matched controls were included in the study. ACE I/D genotyping was performed by PCR. In total, 25.86{\%} of the patients were in New York Heart Association (NYHA) class III and IV at presentation. A total of 67.24{\%} patients had dyspnea, 56.89{\%} had angina pectoris, and 25.28{\%} of the patients had at least one event of syncope. Frequency of occurrence of the disease was more in male patients compared to female patients (P < 0.05). After adjustment for age, sex, body mass index (BMI), and smoking habit, the prevalence of ACE DD genotype, and ACE 'D' allele was significantly higher in patients as compared to controls and was associated with increased risk (DD: OR 2.11, 95{\%} CI 1.27-3.52, P < 0.05; 'D': OR 1.91, 95{\%} CI 1.08-3.35, P < 0.05). The mean septal thickness was higher for DD and ID genotypes (20.40 ± 3.73 mm and 21.82 ± 5.35 mm, respectively) when compared with II genotype (18.63 ± 6.69 mm) in HCM patients, however, the differences were not significant statistically (P > 0.05). The DCM patients with ID genotype showed significantly decreased left ventricular ejection fraction (LVEF) at enrolment (26.50 ± 8.04{\%}) (P = 0.04). Conclusion: Our results suggest thatD allele of ACE I/D polymorphism significantly influences the HCM and DCM phenotypes.",
keywords = "ACE I/D polymorphism, Dilated cardiomyopathy, Hypertrophic cardiomyopathy",
author = "Rai, {Taranjit Singh} and Dhandapany, {Perundurai Subramaniam} and Ahluwalia, {Tarunveer Singh} and Monica Bhardwaj and Ajay Bahl and Talwar, {Kewal Krishan} and Krishnakumar Nair and Andiappan Rathinavel and Madhu Khullar",
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Rai, TS, Dhandapany, PS, Ahluwalia, TS, Bhardwaj, M, Bahl, A, Talwar, KK, Nair, K, Rathinavel, A & Khullar, M 2008, 'ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy', Molecular and Cellular Biochemistry, vol. 311, no. 1-2, pp. 67-72. https://doi.org/10.1007/s11010-007-9695-z

ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. / Rai, Taranjit Singh; Dhandapany, Perundurai Subramaniam; Ahluwalia, Tarunveer Singh; Bhardwaj, Monica; Bahl, Ajay; Talwar, Kewal Krishan; Nair, Krishnakumar; Rathinavel, Andiappan; Khullar, Madhu.

In: Molecular and Cellular Biochemistry, Vol. 311, No. 1-2, 01.04.2008, p. 67-72.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy

AU - Rai, Taranjit Singh

AU - Dhandapany, Perundurai Subramaniam

AU - Ahluwalia, Tarunveer Singh

AU - Bhardwaj, Monica

AU - Bahl, Ajay

AU - Talwar, Kewal Krishan

AU - Nair, Krishnakumar

AU - Rathinavel, Andiappan

AU - Khullar, Madhu

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Aim: The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Methods and results: A total of 174 patients diagnosed with cardiomyopathy (118 with HCM, 51 with DCM, and 5 with RCM) and 164 ethnically, age- and gender-matched controls were included in the study. ACE I/D genotyping was performed by PCR. In total, 25.86% of the patients were in New York Heart Association (NYHA) class III and IV at presentation. A total of 67.24% patients had dyspnea, 56.89% had angina pectoris, and 25.28% of the patients had at least one event of syncope. Frequency of occurrence of the disease was more in male patients compared to female patients (P < 0.05). After adjustment for age, sex, body mass index (BMI), and smoking habit, the prevalence of ACE DD genotype, and ACE 'D' allele was significantly higher in patients as compared to controls and was associated with increased risk (DD: OR 2.11, 95% CI 1.27-3.52, P < 0.05; 'D': OR 1.91, 95% CI 1.08-3.35, P < 0.05). The mean septal thickness was higher for DD and ID genotypes (20.40 ± 3.73 mm and 21.82 ± 5.35 mm, respectively) when compared with II genotype (18.63 ± 6.69 mm) in HCM patients, however, the differences were not significant statistically (P > 0.05). The DCM patients with ID genotype showed significantly decreased left ventricular ejection fraction (LVEF) at enrolment (26.50 ± 8.04%) (P = 0.04). Conclusion: Our results suggest thatD allele of ACE I/D polymorphism significantly influences the HCM and DCM phenotypes.

AB - Aim: The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Methods and results: A total of 174 patients diagnosed with cardiomyopathy (118 with HCM, 51 with DCM, and 5 with RCM) and 164 ethnically, age- and gender-matched controls were included in the study. ACE I/D genotyping was performed by PCR. In total, 25.86% of the patients were in New York Heart Association (NYHA) class III and IV at presentation. A total of 67.24% patients had dyspnea, 56.89% had angina pectoris, and 25.28% of the patients had at least one event of syncope. Frequency of occurrence of the disease was more in male patients compared to female patients (P < 0.05). After adjustment for age, sex, body mass index (BMI), and smoking habit, the prevalence of ACE DD genotype, and ACE 'D' allele was significantly higher in patients as compared to controls and was associated with increased risk (DD: OR 2.11, 95% CI 1.27-3.52, P < 0.05; 'D': OR 1.91, 95% CI 1.08-3.35, P < 0.05). The mean septal thickness was higher for DD and ID genotypes (20.40 ± 3.73 mm and 21.82 ± 5.35 mm, respectively) when compared with II genotype (18.63 ± 6.69 mm) in HCM patients, however, the differences were not significant statistically (P > 0.05). The DCM patients with ID genotype showed significantly decreased left ventricular ejection fraction (LVEF) at enrolment (26.50 ± 8.04%) (P = 0.04). Conclusion: Our results suggest thatD allele of ACE I/D polymorphism significantly influences the HCM and DCM phenotypes.

KW - ACE I/D polymorphism

KW - Dilated cardiomyopathy

KW - Hypertrophic cardiomyopathy

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U2 - 10.1007/s11010-007-9695-z

DO - 10.1007/s11010-007-9695-z

M3 - Article

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JO - Molecular and Cellular Biochemistry

T2 - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

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