A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents

Aaron McConville; Jordan Atchison; Ashlene Roddy; James Davis

doi:10.1016/j.snb.2019.05.023

A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents

Aaron McConville, Jordan Atchison, Ashlene Roddy, James Davis

School of Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

351 Downloads (Pure)

Abstract

A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.

Original language	English
Pages (from-to)	24-31
Number of pages	8
Journal	Sensors and Actuators B: Chemical
Volume	294
Early online date	8 May 2019
DOIs	https://doi.org/10.1016/j.snb.2019.05.023
Publication status	Published (in print/issue) - 1 Sept 2019

Keywords

Drug delivery
Transdermal patch
Thermal
Heat enhanced
Diclofenac

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10.1016/j.snb.2019.05.023

190426 McConville Smart Patch Accepted ManuscriptAuthor Accepted Manuscript, 1.71 MBLicence: CC BY-NC-ND

Cite this

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title = "A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents",

abstract = "A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.",

keywords = "Drug delivery, Transdermal patch, Thermal, Heat enhanced, Diclofenac",

author = "Aaron McConville and Jordan Atchison and Ashlene Roddy and James Davis",

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doi = "10.1016/j.snb.2019.05.023",

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T1 - A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents

AU - McConville, Aaron

AU - Atchison, Jordan

AU - Roddy, Ashlene

AU - Davis, James

PY - 2019/9/1

Y1 - 2019/9/1

N2 - A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.

AB - A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.

KW - Drug delivery

KW - Transdermal patch

KW - Thermal

KW - Heat enhanced

KW - Diclofenac

UR - http://www.sciencedirect.com/science/article/pii/S0925400519307178

UR - https://pure.ulster.ac.uk/en/publications/a-wireless-smart-patch-for-the-controlled-repetitive-transdermal-

U2 - 10.1016/j.snb.2019.05.023

DO - 10.1016/j.snb.2019.05.023

M3 - Article

SN - 0925-4005

VL - 294

SP - 24

EP - 31

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

ER -

A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents

Abstract

Keywords

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