A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents

Aaron McConville, Jordan Atchison, Ashlene Roddy, James Davis

Research output: Contribution to journalArticle

Abstract

A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.
LanguageEnglish
Pages24-31
Number of pages8
JournalSensors and Actuators B: Chemical
Volume294
Early online date8 May 2019
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

drugs
waxes
Waxes
Drug delivery
heaters
delivery
thermoregulation
silver chlorides
Paraffin waxes
Heating
Alkanes
heating
Diclofenac
Bluetooth
composite structures
Composite structures
feedback control
Application programs
Paraffins
alkanes

Keywords

  • Drug delivery
  • Transdermal patch
  • Thermal
  • Heat enhanced
  • Diclofenac

Cite this

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abstract = "A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.",
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A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents. / McConville, Aaron; Atchison, Jordan; Roddy, Ashlene; Davis, James.

Vol. 294, 01.09.2019, p. 24-31.

Research output: Contribution to journalArticle

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AU - Atchison, Jordan

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AU - Davis, James

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AB - A thermoresistive transdermal drug delivery patch based on a n-alkane wax phase change film is described. A composite structure comprising a screen printed silver chloride heater sandwiched with a wax film loaded with diclofenac was developed and the release characteristics upon heating were investigated. The drug is shown to be immobile within the solid film (off state) but is readily delivered upon heating beyond the transition temperature (37 °C). Drug delivery is maintained while the heater is active and terminates upon cooling. The system has been shown to be capable of repetitive on-off cycling with control effected through a Bluetooth connection to a smart phone app with dynamic feedback control/thermoregulation of the patch.

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KW - Diclofenac

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