A voxel based morphometry study investigating brain structural changes in first episode psychosis.

David R Watson, Julie M E Anderson, Feng Bai, Suzanne L Barrett, T Martin McGinnity, Ciaran C Mulholland, Teresa M Rushe, Stephen J Cooper

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    Schizophrenia (SCZ) and bipolar disorder (BP) are associated with neuropathological brain changes, which are believed to disrupt connectivity between brain processes and may have common properties. Patients at first psychotic episode are unique, as one can assess brain alterations at illness inception, when many confounders are reduced or absent. SCZ (N=25) and BP (N=24) patients were recruited in a regional first episode psychosis MRI study. VBM methods were used to study gray matter (GM) and white matter (WM) differences between patient groups and case by case matched controls. For both groups, deficits identified are more discrete than those typically reported in later stages of illness. SCZ patients showed some evidence of GM loss in cortical areas but most notable were in limbic structures such as hippocampus, thalamus and striatum and cerebellum. Consistent with disturbed neural connectivity WM alterations were also observed in limbic structures, the corpus callosum and many subgyral and sublobar regions in the parietal, temporal and frontal lobes. BP patients displayed less evidence of volume changes overall, compared to normal healthy participants, but those changes observed were primarily in WM areas which overlapped with regions identified in SCZ, including thalamus and cerebellum and subgyral and sublobar sites. At first episode of psychosis there is evidence of a neuroanatomical overlap between SCZ and BP with respect to brain structural changes, consistent with disturbed neural connectivity. There are also important differences however in that SCZ displays more extensive structural alteration.
    LanguageEnglish
    Pages91-9
    JournalBehavioural Brain Research
    Volume227
    Issue number1
    Publication statusPublished - 1 Feb 2012

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    Psychotic Disorders
    Schizophrenia
    Bipolar Disorder
    Brain
    Thalamus
    Cerebellum
    Parietal Lobe
    Corpus Callosum
    Frontal Lobe
    Temporal Lobe
    Hippocampus
    Healthy Volunteers
    White Matter
    Gray Matter

    Cite this

    Watson, D. R., Anderson, J. M. E., Bai, F., Barrett, S. L., McGinnity, T. M., Mulholland, C. C., ... Cooper, S. J. (2012). A voxel based morphometry study investigating brain structural changes in first episode psychosis. Behavioural Brain Research, 227(1), 91-9.
    Watson, David R ; Anderson, Julie M E ; Bai, Feng ; Barrett, Suzanne L ; McGinnity, T Martin ; Mulholland, Ciaran C ; Rushe, Teresa M ; Cooper, Stephen J. / A voxel based morphometry study investigating brain structural changes in first episode psychosis. In: Behavioural Brain Research. 2012 ; Vol. 227, No. 1. pp. 91-9.
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    abstract = "Schizophrenia (SCZ) and bipolar disorder (BP) are associated with neuropathological brain changes, which are believed to disrupt connectivity between brain processes and may have common properties. Patients at first psychotic episode are unique, as one can assess brain alterations at illness inception, when many confounders are reduced or absent. SCZ (N=25) and BP (N=24) patients were recruited in a regional first episode psychosis MRI study. VBM methods were used to study gray matter (GM) and white matter (WM) differences between patient groups and case by case matched controls. For both groups, deficits identified are more discrete than those typically reported in later stages of illness. SCZ patients showed some evidence of GM loss in cortical areas but most notable were in limbic structures such as hippocampus, thalamus and striatum and cerebellum. Consistent with disturbed neural connectivity WM alterations were also observed in limbic structures, the corpus callosum and many subgyral and sublobar regions in the parietal, temporal and frontal lobes. BP patients displayed less evidence of volume changes overall, compared to normal healthy participants, but those changes observed were primarily in WM areas which overlapped with regions identified in SCZ, including thalamus and cerebellum and subgyral and sublobar sites. At first episode of psychosis there is evidence of a neuroanatomical overlap between SCZ and BP with respect to brain structural changes, consistent with disturbed neural connectivity. There are also important differences however in that SCZ displays more extensive structural alteration.",
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    Watson, DR, Anderson, JME, Bai, F, Barrett, SL, McGinnity, TM, Mulholland, CC, Rushe, TM & Cooper, SJ 2012, 'A voxel based morphometry study investigating brain structural changes in first episode psychosis.', Behavioural Brain Research, vol. 227, no. 1, pp. 91-9.

    A voxel based morphometry study investigating brain structural changes in first episode psychosis. / Watson, David R; Anderson, Julie M E; Bai, Feng; Barrett, Suzanne L; McGinnity, T Martin; Mulholland, Ciaran C; Rushe, Teresa M; Cooper, Stephen J.

    In: Behavioural Brain Research, Vol. 227, No. 1, 01.02.2012, p. 91-9.

    Research output: Contribution to journalArticle

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    AU - Watson, David R

    AU - Anderson, Julie M E

    AU - Bai, Feng

    AU - Barrett, Suzanne L

    AU - McGinnity, T Martin

    AU - Mulholland, Ciaran C

    AU - Rushe, Teresa M

    AU - Cooper, Stephen J

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    N2 - Schizophrenia (SCZ) and bipolar disorder (BP) are associated with neuropathological brain changes, which are believed to disrupt connectivity between brain processes and may have common properties. Patients at first psychotic episode are unique, as one can assess brain alterations at illness inception, when many confounders are reduced or absent. SCZ (N=25) and BP (N=24) patients were recruited in a regional first episode psychosis MRI study. VBM methods were used to study gray matter (GM) and white matter (WM) differences between patient groups and case by case matched controls. For both groups, deficits identified are more discrete than those typically reported in later stages of illness. SCZ patients showed some evidence of GM loss in cortical areas but most notable were in limbic structures such as hippocampus, thalamus and striatum and cerebellum. Consistent with disturbed neural connectivity WM alterations were also observed in limbic structures, the corpus callosum and many subgyral and sublobar regions in the parietal, temporal and frontal lobes. BP patients displayed less evidence of volume changes overall, compared to normal healthy participants, but those changes observed were primarily in WM areas which overlapped with regions identified in SCZ, including thalamus and cerebellum and subgyral and sublobar sites. At first episode of psychosis there is evidence of a neuroanatomical overlap between SCZ and BP with respect to brain structural changes, consistent with disturbed neural connectivity. There are also important differences however in that SCZ displays more extensive structural alteration.

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    Watson DR, Anderson JME, Bai F, Barrett SL, McGinnity TM, Mulholland CC et al. A voxel based morphometry study investigating brain structural changes in first episode psychosis. Behavioural Brain Research. 2012 Feb 1;227(1):91-9.