A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

N Nomikou, K Curtis, C McEwan, Barry O'Hagan, Bridgeen Callan, J Callan, AP McHale

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A PLGA-based multifunctional biodegradable nanoparticle platform co-harboring hematoporporphyrin and indocyanine green has been developed. In vitro studies demonstrate ultrasound and light stimulated generation of cytotoxic reactive oxygen species. In vivo studies demonstrate that the ICG component facilitates nIR fluorescence imaging that demonstrates accumulation of IV- administered nanoparticles in tumours. In vivo studies also demonstrate ultrasound- and light-mediated inhibition of tumor growth in animals treated with the platform. Since the platform consists entirely of clinically-approved agents it could find use in sonodynamic- and photodynamic-based therapies for cancer.
LanguageEnglish
Pages414-421
Number of pages8
JournalActa Biomaterialia
Volume49
Early online date14 Nov 2016
DOIs
Publication statusPublished - 28 Feb 2017

Fingerprint

Photochemotherapy
Nanoparticles
Tumors
Ultrasonics
Indocyanine Green
Light
Reactive Oxygen Species
Neoplasms
Animals
Fluorescence
Optical Imaging
Imaging techniques
Oxygen
Growth
polylactic acid-polyglycolic acid copolymer

Keywords

  • nanoparticle
  • sonodynamic
  • photodynamic
  • cancer
  • real-time
  • imaging
  • therapy

Cite this

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AU - Callan, Bridgeen

AU - Callan, J

AU - McHale, AP

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AB - A PLGA-based multifunctional biodegradable nanoparticle platform co-harboring hematoporporphyrin and indocyanine green has been developed. In vitro studies demonstrate ultrasound and light stimulated generation of cytotoxic reactive oxygen species. In vivo studies demonstrate that the ICG component facilitates nIR fluorescence imaging that demonstrates accumulation of IV- administered nanoparticles in tumours. In vivo studies also demonstrate ultrasound- and light-mediated inhibition of tumor growth in animals treated with the platform. Since the platform consists entirely of clinically-approved agents it could find use in sonodynamic- and photodynamic-based therapies for cancer.

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KW - photodynamic

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