A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

N Nomikou, K Curtis, C McEwan, Barry O'Hagan, Bridgeen Callan, J Callan, AP McHale

Research output: Contribution to journalArticle

12 Citations (Scopus)
10 Downloads (Pure)

Abstract

A PLGA-based multifunctional biodegradable nanoparticle platform co-harboring hematoporporphyrin and indocyanine green has been developed. In vitro studies demonstrate ultrasound and light stimulated generation of cytotoxic reactive oxygen species. In vivo studies demonstrate that the ICG component facilitates nIR fluorescence imaging that demonstrates accumulation of IV- administered nanoparticles in tumours. In vivo studies also demonstrate ultrasound- and light-mediated inhibition of tumor growth in animals treated with the platform. Since the platform consists entirely of clinically-approved agents it could find use in sonodynamic- and photodynamic-based therapies for cancer.
Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalActa Biomaterialia
Volume49
Early online date14 Nov 2016
DOIs
Publication statusPublished - 28 Feb 2017

Keywords

  • nanoparticle
  • sonodynamic
  • photodynamic
  • cancer
  • real-time
  • imaging
  • therapy

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    Anthony Mc Hale

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