A study of the electrospray ionisation of pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer

Franklin Smyth, Stephen McClean, V. N. Ramachandran

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Abstract

The electrospray ionisation (ESI) of sixteen pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer have been investigated. Sequential product ion fragmentation experiments (MSn) were performed in order to elucidate the degradation pathways for these compounds. Comparisons were also made between these ESI spectra and those obtained under electron impact (EI) conditions. The data presented in this paper provide useful information on the effect of different substituents on the ionisation/fragmentation processes and can be used in the characterisation of this important class of drugs and their metabolites.
LanguageEnglish
Pages2061-2069
JournalRapid Communications in Mass Spectrometry
Volume14
Issue number21
Publication statusPublished - 2000

Fingerprint

Electrospray ionization
Mass spectrometers
Ions
Metabolites
Ionization
Degradation
Electrons
Pharmaceutical Preparations
Experiments
Bz-423

Keywords

  • Benzodiazepines/analysis/chemistry/metabolism
  • Molecular Structure
  • Spectrometry
  • Mass
  • Electrospray Ionization/methods

Cite this

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T1 - A study of the electrospray ionisation of pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer

AU - Smyth, Franklin

AU - McClean, Stephen

AU - Ramachandran, V. N.

N1 - LR: 20061115; PUBM: Print; JID: 8802365; 0 (Benzodiazepines); ppublish

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AB - The electrospray ionisation (ESI) of sixteen pharmacologically significant 1,4-benzodiazepines and their subsequent fragmentation using an ion-trap mass spectrometer have been investigated. Sequential product ion fragmentation experiments (MSn) were performed in order to elucidate the degradation pathways for these compounds. Comparisons were also made between these ESI spectra and those obtained under electron impact (EI) conditions. The data presented in this paper provide useful information on the effect of different substituents on the ionisation/fragmentation processes and can be used in the characterisation of this important class of drugs and their metabolites.

KW - Benzodiazepines/analysis/chemistry/metabolism

KW - Molecular Structure

KW - Spectrometry

KW - Mass

KW - Electrospray Ionization/methods

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EP - 2069

JO - Rapid Communications in Mass Spectrometry

T2 - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

SN - 0951-4198

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ER -