A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines

F. O'Donnell, T. J. P. Smyth, V. N. Ramachandran, Franklin Smyth

    Research output: Contribution to journalArticle

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    Abstract

    The antimicrobial activities of 60 naturally occurring and synthetic quinolines were studied. The quinolines were organised into seven structural subgroups and, using an in-house microtitre assay, were tested against a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of meticillin-resistant Staphylococcus aureus (MRSA). The quinolines exhibiting good bioactivity [i.e. low minimum inhibitory concentration (MIC)] against two S. aureus strains were then assessed for their antimicrobial activity against a range of eight clinically isolated MRSA strains. The study showed that 30 of the tested compounds displayed antimicrobial activity, mostly against Gram-positive bacteria. The effects of substituent groups on the bioactivity of these quinolines have also been discussed. The quinoline 4-hydroxy-3-iodo-quinol-2-one (11) exhibited significant antimicrobial activity, being active against the MRSA clinical isolates with MIC values comparable with the antibiotic vancomycin used in the treatment of MRSA infections. In particular, 4-hydroxy-3-iodo-quinol-2-one (11) showed MIC values of 0.097 mu g/mL against an Irish hospital MRSA-1 strain and 0.049 mu g/mL against a distinct MRSA strain as well as a non-typeable MRSA strain. (c) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
    LanguageEnglish
    Pages30-38
    JournalInternational Journal of Antimicrobial Agents
    Volume35
    Issue number1
    DOIs
    Publication statusPublished - Jan 2010

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    Quinolines
    Methicillin
    Staphylococcus aureus
    Microbial Sensitivity Tests
    Hydroquinones
    Gram-Positive Bacteria
    Vancomycin
    Gram-Negative Bacteria
    Anti-Bacterial Agents
    Drug Therapy

    Cite this

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    abstract = "The antimicrobial activities of 60 naturally occurring and synthetic quinolines were studied. The quinolines were organised into seven structural subgroups and, using an in-house microtitre assay, were tested against a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of meticillin-resistant Staphylococcus aureus (MRSA). The quinolines exhibiting good bioactivity [i.e. low minimum inhibitory concentration (MIC)] against two S. aureus strains were then assessed for their antimicrobial activity against a range of eight clinically isolated MRSA strains. The study showed that 30 of the tested compounds displayed antimicrobial activity, mostly against Gram-positive bacteria. The effects of substituent groups on the bioactivity of these quinolines have also been discussed. The quinoline 4-hydroxy-3-iodo-quinol-2-one (11) exhibited significant antimicrobial activity, being active against the MRSA clinical isolates with MIC values comparable with the antibiotic vancomycin used in the treatment of MRSA infections. In particular, 4-hydroxy-3-iodo-quinol-2-one (11) showed MIC values of 0.097 mu g/mL against an Irish hospital MRSA-1 strain and 0.049 mu g/mL against a distinct MRSA strain as well as a non-typeable MRSA strain. (c) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.",
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    A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines. / O'Donnell, F.; Smyth, T. J. P.; Ramachandran, V. N.; Smyth, Franklin.

    In: International Journal of Antimicrobial Agents, Vol. 35, No. 1, 01.2010, p. 30-38.

    Research output: Contribution to journalArticle

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