Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 30-38 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2010 |
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A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines. / O'Donnell, F.; Smyth, T. J. P.; Ramachandran, V. N.; Smyth, Franklin.
In: International Journal of Antimicrobial Agents, Vol. 35, No. 1, 01.2010, p. 30-38.Research output: Contribution to journal › Article
TY - JOUR
T1 - A study of the antimicrobial activity of selected synthetic and naturally occurring quinolines
AU - O'Donnell, F.
AU - Smyth, T. J. P.
AU - Ramachandran, V. N.
AU - Smyth, Franklin
PY - 2010/1
Y1 - 2010/1
N2 - The antimicrobial activities of 60 naturally occurring and synthetic quinolines were studied. The quinolines were organised into seven structural subgroups and, using an in-house microtitre assay, were tested against a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of meticillin-resistant Staphylococcus aureus (MRSA). The quinolines exhibiting good bioactivity [i.e. low minimum inhibitory concentration (MIC)] against two S. aureus strains were then assessed for their antimicrobial activity against a range of eight clinically isolated MRSA strains. The study showed that 30 of the tested compounds displayed antimicrobial activity, mostly against Gram-positive bacteria. The effects of substituent groups on the bioactivity of these quinolines have also been discussed. The quinoline 4-hydroxy-3-iodo-quinol-2-one (11) exhibited significant antimicrobial activity, being active against the MRSA clinical isolates with MIC values comparable with the antibiotic vancomycin used in the treatment of MRSA infections. In particular, 4-hydroxy-3-iodo-quinol-2-one (11) showed MIC values of 0.097 mu g/mL against an Irish hospital MRSA-1 strain and 0.049 mu g/mL against a distinct MRSA strain as well as a non-typeable MRSA strain. (c) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
AB - The antimicrobial activities of 60 naturally occurring and synthetic quinolines were studied. The quinolines were organised into seven structural subgroups and, using an in-house microtitre assay, were tested against a range of Gram-positive and Gram-negative bacteria, including a hospital isolate of meticillin-resistant Staphylococcus aureus (MRSA). The quinolines exhibiting good bioactivity [i.e. low minimum inhibitory concentration (MIC)] against two S. aureus strains were then assessed for their antimicrobial activity against a range of eight clinically isolated MRSA strains. The study showed that 30 of the tested compounds displayed antimicrobial activity, mostly against Gram-positive bacteria. The effects of substituent groups on the bioactivity of these quinolines have also been discussed. The quinoline 4-hydroxy-3-iodo-quinol-2-one (11) exhibited significant antimicrobial activity, being active against the MRSA clinical isolates with MIC values comparable with the antibiotic vancomycin used in the treatment of MRSA infections. In particular, 4-hydroxy-3-iodo-quinol-2-one (11) showed MIC values of 0.097 mu g/mL against an Irish hospital MRSA-1 strain and 0.049 mu g/mL against a distinct MRSA strain as well as a non-typeable MRSA strain. (c) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
U2 - 10.1016/j.ijantimicag.2009.06.031
DO - 10.1016/j.ijantimicag.2009.06.031
M3 - Article
VL - 35
SP - 30
EP - 38
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 1
ER -