A review of connectivity map and computational approaches in pharmacogenomics

Aliyu Musa, Laleh Soltan Ghoraie, Shu-Dong Zhang, Galina Glazko, Olli Yli-Harja, Matthias Dehmer, Benjamin Haibe-Kains, Frank Emmert-Streib

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications.
LanguageEnglish
Pages506-523
Number of pages18
JournalBriefings in Bioinformatics
Volume19
Issue number3
DOIs
Publication statusPublished - 1 May 2018

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Pharmacogenetics
Libraries
Systems Biology
Drug Design
Databases
Pharmacology

Cite this

Musa, A., Ghoraie, L. S., Zhang, S-D., Glazko, G., Yli-Harja, O., Dehmer, M., ... Emmert-Streib, F. (2018). A review of connectivity map and computational approaches in pharmacogenomics. Briefings in Bioinformatics, 19(3), 506-523. https://doi.org/10.1093/bib/bbw112
Musa, Aliyu ; Ghoraie, Laleh Soltan ; Zhang, Shu-Dong ; Glazko, Galina ; Yli-Harja, Olli ; Dehmer, Matthias ; Haibe-Kains, Benjamin ; Emmert-Streib, Frank. / A review of connectivity map and computational approaches in pharmacogenomics. In: Briefings in Bioinformatics. 2018 ; Vol. 19, No. 3. pp. 506-523.
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Musa, A, Ghoraie, LS, Zhang, S-D, Glazko, G, Yli-Harja, O, Dehmer, M, Haibe-Kains, B & Emmert-Streib, F 2018, 'A review of connectivity map and computational approaches in pharmacogenomics', Briefings in Bioinformatics, vol. 19, no. 3, pp. 506-523. https://doi.org/10.1093/bib/bbw112

A review of connectivity map and computational approaches in pharmacogenomics. / Musa, Aliyu; Ghoraie, Laleh Soltan ; Zhang, Shu-Dong; Glazko, Galina; Yli-Harja, Olli; Dehmer, Matthias; Haibe-Kains, Benjamin; Emmert-Streib, Frank.

In: Briefings in Bioinformatics, Vol. 19, No. 3, 01.05.2018, p. 506-523.

Research output: Contribution to journalArticle

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