TY - JOUR
T1 - A review of connectivity map and computational approaches in pharmacogenomics
AU - Musa, Aliyu
AU - Ghoraie, Laleh Soltan
AU - Zhang, Shu-Dong
AU - Glazko, Galina
AU - Yli-Harja, Olli
AU - Dehmer, Matthias
AU - Haibe-Kains, Benjamin
AU - Emmert-Streib, Frank
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications.
AB - Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications.
U2 - 10.1093/bib/bbw112
DO - 10.1093/bib/bbw112
M3 - Article
C2 - 28069634
VL - 19
SP - 506
EP - 523
JO - Briefings in Bioinformatics
JF - Briefings in Bioinformatics
SN - 1467-5463
IS - 3
ER -
