A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer

Narinder Singh; Navneet Kaur; Ray C. Mulrooney; John F. Callan

doi:10.1016/j.tetlet.2008.09.052

A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer

Narinder Singh, Navneet Kaur, Ray C. Mulrooney, John F. Callan

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	6690-6692
Journal	Tetrahedron Letters
Volume	49
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2008.09.052
Publication status	Published (in print/issue) - Nov 2008

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title = "A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer",

abstract = "A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.",

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AU - Singh, Narinder

AU - Kaur, Navneet

AU - Mulrooney, Ray C.

AU - Callan, John F.

PY - 2008/11

Y1 - 2008/11

N2 - A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.

AB - A simple fluorescent sensor has been developed for the ratiometric recognition of Mg2+ in semi-aqueous solution at pH 7.0. The sensor, a Schiff base, undergoes Excited State Intramolecular Proton Transfer (ESIPT) to generate a keto tautomer with proficient Mg2+ binding capability. The sensor displays good selectivity over other metal ions including alkali/alkali earth ions and can measure Mg2+ ion concentration between 2.0 and 30.0 mu M. The binding stoichiometry was established as 2:1 (host:guest) with an association constant (K-21) of (1.4 +/- 0.1) x 10(4) m(-2). The sensor could potentially be used to detect conditions such as hypermagnesaemia. (C) 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2008.09.052

DO - 10.1016/j.tetlet.2008.09.052

M3 - Article

VL - 49

SP - 6690

EP - 6692

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47

ER -

A ratiometric fluorescent probe for magnesium employing excited state intramolecular proton transfer

Abstract

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