A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach

Graham Hamilton, L. Fullerton, Bridgeen McCaughan, R.F. Donnelly, J Callan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A polymeric ratiometric fluorescent sensor for Zn(II) has been developed based on a Zn(II) responsive naphthalimide fluorophore (λEM 535 nm) and a Zn(II) insensitive rhodamine calibration fluorophore (λEM 579 nm) both coupled to a common poly(allyl amine) backbone. A concentration dependent increase in the ratiometric response (I 535 nm/I579 nm) was observed in the 0-25 mM Zn(II) ion range for the sensor in aqueous buffer. The effect of dilution on the ratiometric intensity of the polymeric sensor was also studied and no change in ratiometric response was observed upon dilution to 50 of its original concentration. In contrast, when the polymeric sensor was incorporated within a Gantrez AN-139 hydrogel matrix, a linear ratiometric response was observed upon addition of increasing amounts of Zn(II) to the gel. Therefore, this approach offers the opportunity to determine Zn(II) concentration in environments where sensor concentration may vary dramatically. © the Partner Organisations 2014.
LanguageEnglish
Pages2823-2830
JournalNew Journal of Chemistry
Volume38
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Fluorophores
Hydrogel
Zinc
Sensors
Dilution
Naphthalimides
Rhodamines
Amines
Buffers
Gels
Calibration
Ions

Keywords

  • allylamine derivative
  • naphthalimide derivative
  • poly(allylamine)
  • rhodamine
  • unclassified drug
  • zinc
  • article
  • dilution
  • fluorescence
  • hydrogel
  • priority journal
  • sensor

Cite this

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title = "A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach",
abstract = "A polymeric ratiometric fluorescent sensor for Zn(II) has been developed based on a Zn(II) responsive naphthalimide fluorophore (λEM 535 nm) and a Zn(II) insensitive rhodamine calibration fluorophore (λEM 579 nm) both coupled to a common poly(allyl amine) backbone. A concentration dependent increase in the ratiometric response (I 535 nm/I579 nm) was observed in the 0-25 mM Zn(II) ion range for the sensor in aqueous buffer. The effect of dilution on the ratiometric intensity of the polymeric sensor was also studied and no change in ratiometric response was observed upon dilution to 50 of its original concentration. In contrast, when the polymeric sensor was incorporated within a Gantrez AN-139 hydrogel matrix, a linear ratiometric response was observed upon addition of increasing amounts of Zn(II) to the gel. Therefore, this approach offers the opportunity to determine Zn(II) concentration in environments where sensor concentration may vary dramatically. {\circledC} the Partner Organisations 2014.",
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A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach. / Hamilton, Graham; Fullerton, L.; McCaughan, Bridgeen; Donnelly, R.F.; Callan, J.

In: New Journal of Chemistry, Vol. 38, No. 7, 2014, p. 2823-2830.

Research output: Contribution to journalArticle

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T1 - A ratiometric fluorescent hydrogel sensor for zinc(II) based on a two fluorophore approach

AU - Hamilton, Graham

AU - Fullerton, L.

AU - McCaughan, Bridgeen

AU - Donnelly, R.F.

AU - Callan, J

N1 - cited By 7

PY - 2014

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AB - A polymeric ratiometric fluorescent sensor for Zn(II) has been developed based on a Zn(II) responsive naphthalimide fluorophore (λEM 535 nm) and a Zn(II) insensitive rhodamine calibration fluorophore (λEM 579 nm) both coupled to a common poly(allyl amine) backbone. A concentration dependent increase in the ratiometric response (I 535 nm/I579 nm) was observed in the 0-25 mM Zn(II) ion range for the sensor in aqueous buffer. The effect of dilution on the ratiometric intensity of the polymeric sensor was also studied and no change in ratiometric response was observed upon dilution to 50 of its original concentration. In contrast, when the polymeric sensor was incorporated within a Gantrez AN-139 hydrogel matrix, a linear ratiometric response was observed upon addition of increasing amounts of Zn(II) to the gel. Therefore, this approach offers the opportunity to determine Zn(II) concentration in environments where sensor concentration may vary dramatically. © the Partner Organisations 2014.

KW - allylamine derivative

KW - naphthalimide derivative

KW - poly(allylamine)

KW - rhodamine

KW - unclassified drug

KW - zinc

KW - article

KW - dilution

KW - fluorescence

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KW - priority journal

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