A rat model of infection by Salmonella typhimurium or Salm-enteritidis

Patrick Naughton, G Grant, RJ Spencer, S Bardocz

Research output: Contribution to journalArticle

Abstract

Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that the salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.
LanguageEnglish
Pages651-656
JournalJournal of Applied Bacteriology
Volume81
Issue number6
Publication statusPublished - 1 Dec 1996

Fingerprint

Salmonella typhimurium
Salmonella Infections
Infection
Large Intestine
Intestinal Mucosa
Ileum
Intubation
Salmonella
Gastrointestinal Tract
Bacteria

Keywords

  • Rat model
  • Salmonella
  • self limiting infection

Cite this

Naughton, P., Grant, G., Spencer, RJ., & Bardocz, S. (1996). A rat model of infection by Salmonella typhimurium or Salm-enteritidis. 81(6), 651-656.
Naughton, Patrick ; Grant, G ; Spencer, RJ ; Bardocz, S. / A rat model of infection by Salmonella typhimurium or Salm-enteritidis. 1996 ; Vol. 81, No. 6. pp. 651-656.
@article{943c4f276a314d12be371e70748d0240,
title = "A rat model of infection by Salmonella typhimurium or Salm-enteritidis",
abstract = "Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that the salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.",
keywords = "Rat model, Salmonella, self limiting infection",
author = "Patrick Naughton and G Grant and RJ Spencer and S Bardocz",
year = "1996",
month = "12",
day = "1",
language = "English",
volume = "81",
pages = "651--656",
number = "6",

}

Naughton, P, Grant, G, Spencer, RJ & Bardocz, S 1996, 'A rat model of infection by Salmonella typhimurium or Salm-enteritidis', vol. 81, no. 6, pp. 651-656.

A rat model of infection by Salmonella typhimurium or Salm-enteritidis. / Naughton, Patrick; Grant, G; Spencer, RJ; Bardocz, S.

Vol. 81, No. 6, 01.12.1996, p. 651-656.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A rat model of infection by Salmonella typhimurium or Salm-enteritidis

AU - Naughton, Patrick

AU - Grant, G

AU - Spencer, RJ

AU - Bardocz, S

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that the salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.

AB - Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that the salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.

KW - Rat model

KW - Salmonella

KW - self limiting infection

M3 - Article

VL - 81

SP - 651

EP - 656

IS - 6

ER -

Naughton P, Grant G, Spencer RJ, Bardocz S. A rat model of infection by Salmonella typhimurium or Salm-enteritidis. 1996 Dec 1;81(6):651-656.