A rat model of infection by Salmonella typhimurium or Salm-enteritidis

Patrick Naughton, G Grant, RJ Spencer, S Bardocz

Research output: Contribution to journalArticlepeer-review


Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that the salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.
Original languageEnglish
Pages (from-to)651-656
JournalJournal of Applied Bacteriology
Issue number6
Publication statusPublished (in print/issue) - 1 Dec 1996


  • Rat model
  • Salmonella
  • self limiting infection


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