A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy

D McKenna, D Spence, SE Haggan, E McCrum, JC Dornan, TR Lappin

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.
    LanguageEnglish
    Pages99-103
    JournalClinical and Laboratory Haematology
    Volume25
    Issue number2
    Publication statusPublished - Apr 2003

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    Mineral Waters
    Iron
    ferrous sulfate
    Pregnancy
    Ferritins
    Compliance
    Placebos
    Control Groups
    Dyspepsia
    Wales
    Tablets
    Obstetrics
    Outcome Assessment (Health Care)
    Water
    Population

    Cite this

    McKenna, D., Spence, D., Haggan, SE., McCrum, E., Dornan, JC., & Lappin, TR. (2003). A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. Clinical and Laboratory Haematology, 25(2), 99-103.
    McKenna, D ; Spence, D ; Haggan, SE ; McCrum, E ; Dornan, JC ; Lappin, TR. / A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. In: Clinical and Laboratory Haematology. 2003 ; Vol. 25, No. 2. pp. 99-103.
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    McKenna, D, Spence, D, Haggan, SE, McCrum, E, Dornan, JC & Lappin, TR 2003, 'A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy', Clinical and Laboratory Haematology, vol. 25, no. 2, pp. 99-103.

    A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. / McKenna, D; Spence, D; Haggan, SE; McCrum, E; Dornan, JC; Lappin, TR.

    In: Clinical and Laboratory Haematology, Vol. 25, No. 2, 04.2003, p. 99-103.

    Research output: Contribution to journalArticle

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    T1 - A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy

    AU - McKenna, D

    AU - Spence, D

    AU - Haggan, SE

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    AU - Dornan, JC

    AU - Lappin, TR

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    N2 - Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.

    AB - Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.

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