A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool

M.A. Aldeyab; M.P. Kearney; J.C. McElnay; F.A. Magee; G. Conlon; J. MacIntyre; B. McCullagh; C. Ferguson; A. Friel; C Gormley; S. McElroy; T. Boyce; A. McCorry; A. Muller; H. Goossens; M.G. Scott

doi:10.1017/S095026881100241X

A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool

M.A. Aldeyab, M.P. Kearney, J.C. McElnay, F.A. Magee, G. Conlon, J. MacIntyre, B. McCullagh, C. Ferguson, A. Friel, C Gormley, S. McElroy, T. Boyce, A. McCorry, A. Muller, H. Goossens, M.G. Scott

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Abstract

The objective of this research was to assess current patterns of hospital antibiotic prescribing in Northern Ireland and to determine targets for improving the quality of antibiotic prescribing. A point prevalence survey was conducted in four acute teaching hospitals. The most commonly used antibiotics were combinations of penicillins including β-lactamase inhibitors (33.6%), metronidazole (9.1%), and macrolides (8.1%). The indication for treatment was recorded in 84.3% of the prescribing episodes. A small fraction (3.9%) of the surgical prophylactic antibiotic prescriptions was for >24 h. The results showed that overall 52.4% of the prescribed antibiotics were in compliance with the hospital antibiotic guidelines. The findings identified the following indicators as targets for quality improvement: indication recorded in patient notes, the duration of surgical prophylaxis and compliance with hospital antibiotic guidelines. The results strongly suggest that antibiotic use could be improved by taking steps to address the identified targets for quality improvement. © 2011 Cambridge University Press.

Original language	English
Pages (from-to)	1714-1720
Number of pages	7
Journal	Epidemiology and Infection
Volume	140
Issue number	9
Early online date	24 Nov 2011
DOIs	https://doi.org/10.1017/S095026881100241X
Publication status	Published (in print/issue) - Sept 2012

Bibliographical note

Cited By :7

Export Date: 15 September 2018

CODEN: EPINE

Correspondence Address: Aldeyab, M.A.; Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast/Pharmacy, Belfast BT9 7BL, United Kingdom; email: [email protected]

Chemicals/CAS: amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; ciprofloxacin, 85721-33-1; clarithromycin, 81103-11-9; lincosamide, 80738-43-8; metronidazole, 39322-38-8, 443-48-1; teicoplanin, 61036-62-2, 61036-64-4; trimethoprim, 738-70-5; vancomycin, 1404-90-6, 1404-93-9; Anti-Bacterial Agents

References: Gyssens, I.C., Quality measures of antimicrobial drug use (2001) International Journal of Antimicrobial Agents, 17 (1), pp. 9-19. , DOI 10.1016/S0924-8579(00)00208-9, PII S0924857900002089; Paterson, D.L., The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals (2006) Clinical Infectious Diseases, 42 (SUPPL. 2), pp. S90-95; Smith, S.V., Gould, I.M., Optimization of antibiotic dosing schedules in the light of increasing antibiotic resistance (2004) Expert Review of Anti-Infective Therapy, 2 (2), pp. 227-234. , DOI 10.1586/14737140.2.2.227; MacDougall, C., Polk, R.E., Antimicrobial stewardship programs in health care systems (2005) Clinical Microbiology Reviews, 18 (4), pp. 638-656. , DOI 10.1128/CMR.18.4.638-656.2005; Aldeyab, M.A., A point prevalence survey of antibiotic prescriptions: Benchmarking and patterns of use (2010) British Journal of Clinical Pharmacology, 71, pp. 293-296; Seaton, R.A., Nathwani, D., Burton, P., McLaughlin, C., MacKenzie, A.R., Dundas, S., Ziglam, H., Douglas, E., Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Antimicrobial Audit Tool (GAAT) (2007) International Journal of Antimicrobial Agents, 29 (6), pp. 693-699. , DOI 10.1016/j.ijantimicag.2006.10.020, PII S092485790700091X; Ansari, F., The european surveillance of antimicrobial consumption (ESAC) point-prevalence survey of antibacterial use in 20 european hospitals in 2006 (2009) Clinical Infectious Diseases, 49, pp. 1496-1504; Vander Stichele, R.H., Elseviers, M.M., Ferech, M., Blot, S., Goossens, H., European Surveillance of Antimicrobial Consumption (ESAC): Data collection performance and methodological approach (2004) British Journal of Clinical Pharmacology, 58 (4), pp. 419-428. , DOI 10.1111/j.1365-2125.2004.02164.x; MacDougall, C., Polk, R.E., Variability in rates of use of antibacterials among 130 US hospitals and risk-adjustment models for interhospital comparison (2008) Infection Control and Hospital Epidemiology, 29 (3), pp. 203-211. , DOI 10.1086/528810; Aldeyab, M.A., Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant staphylococcus aureus: A time-series analysis (2008) Journal of Antimicrobial Chemotherapy, 62, pp. 593-600; Aldeyab, M.A., Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of clostridium difficile-associated diarrhea in hospitalized patients (2009) Antimicrobial Agents and Chemotherapy, 53, pp. 2082-2088; Zarb, P., Goossens, H., European surveillance of antimicrobial consumption (ESAC): Value of a point-prevalence survey of antimicrobial use across europe (2011) Drugs, 71, pp. 745-755; Davey, P., Interventions to improve antibiotic prescribing practices for hospital inpatients (2005) Cochrane Database of Systematic Reviews, (4). , Art No CD003543

Keywords

Antibiotic use
ESAC
point prevalence surveys
quality improvement
aminoglycoside antibiotic agent
amoxicillin plus clavulanic acid
antibiotic agent
beta lactamase inhibitor
carbapenem derivative
cephalosporin derivative
ciprofloxacin
clarithromycin
imidazole derivative
lincosamide
macrolide
metronidazole
monobactam derivative
nitrofuran derivative
penicillin derivative
piperacillin plus tazobactam
quinoline derived antiinfective agent
steroid
sulfonamide
teicoplanin
tetracycline derivative
trimethoprim
trimethoprim derivative
vancomycin
adult
aged
antibiotic prophylaxis
article
community acquired infection
drug use
female
health care quality
health survey
hospital infection
human
infection
Ireland
major clinical study
male
medical audit
point prevalence survey
postoperative infection
practice guideline
prescription
teaching hospital
treatment duration
treatment indication
Aged
Aged, 80 and over
Anti-Bacterial Agents
Drug Prescriptions
Drug Utilization Review
Female
Guideline Adherence
Health Care Surveys
Hospitals, Teaching
Humans
Male
Middle Aged
Northern Ireland

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S095026881100241X

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864483915&doi=10.1017%2fS095026881100241X&partnerID=40&md5=dc6d446650a1e718cb1c5bccbf45a0ca

Cite this

Aldeyab, M. A., Kearney, M. P., McElnay, J. C., Magee, F. A., Conlon, G., MacIntyre, J., McCullagh, B., Ferguson, C., Friel, A., Gormley, C., McElroy, S., Boyce, T., McCorry, A., Muller, A., Goossens, H., & Scott, M. G. (2012). A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool. Epidemiology and Infection, 140(9), 1714-1720. https://doi.org/10.1017/S095026881100241X

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title = "A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool",

abstract = "The objective of this research was to assess current patterns of hospital antibiotic prescribing in Northern Ireland and to determine targets for improving the quality of antibiotic prescribing. A point prevalence survey was conducted in four acute teaching hospitals. The most commonly used antibiotics were combinations of penicillins including β-lactamase inhibitors (33.6%), metronidazole (9.1%), and macrolides (8.1%). The indication for treatment was recorded in 84.3% of the prescribing episodes. A small fraction (3.9%) of the surgical prophylactic antibiotic prescriptions was for >24 h. The results showed that overall 52.4% of the prescribed antibiotics were in compliance with the hospital antibiotic guidelines. The findings identified the following indicators as targets for quality improvement: indication recorded in patient notes, the duration of surgical prophylaxis and compliance with hospital antibiotic guidelines. The results strongly suggest that antibiotic use could be improved by taking steps to address the identified targets for quality improvement. {\textcopyright} 2011 Cambridge University Press.",

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author = "M.A. Aldeyab and M.P. Kearney and J.C. McElnay and F.A. Magee and G. Conlon and J. MacIntyre and B. McCullagh and C. Ferguson and A. Friel and C Gormley and S. McElroy and T. Boyce and A. McCorry and A. Muller and H. Goossens and M.G. Scott",

note = "Cited By :7 Export Date: 15 September 2018 CODEN: EPINE Correspondence Address: Aldeyab, M.A.; Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast/Pharmacy, Belfast BT9 7BL, United Kingdom; email: [email protected] Chemicals/CAS: amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; ciprofloxacin, 85721-33-1; clarithromycin, 81103-11-9; lincosamide, 80738-43-8; metronidazole, 39322-38-8, 443-48-1; teicoplanin, 61036-62-2, 61036-64-4; trimethoprim, 738-70-5; vancomycin, 1404-90-6, 1404-93-9; Anti-Bacterial Agents References: Gyssens, I.C., Quality measures of antimicrobial drug use (2001) International Journal of Antimicrobial Agents, 17 (1), pp. 9-19. , DOI 10.1016/S0924-8579(00)00208-9, PII S0924857900002089; Paterson, D.L., The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals (2006) Clinical Infectious Diseases, 42 (SUPPL. 2), pp. S90-95; Smith, S.V., Gould, I.M., Optimization of antibiotic dosing schedules in the light of increasing antibiotic resistance (2004) Expert Review of Anti-Infective Therapy, 2 (2), pp. 227-234. , DOI 10.1586/14737140.2.2.227; MacDougall, C., Polk, R.E., Antimicrobial stewardship programs in health care systems (2005) Clinical Microbiology Reviews, 18 (4), pp. 638-656. , DOI 10.1128/CMR.18.4.638-656.2005; Aldeyab, M.A., A point prevalence survey of antibiotic prescriptions: Benchmarking and patterns of use (2010) British Journal of Clinical Pharmacology, 71, pp. 293-296; Seaton, R.A., Nathwani, D., Burton, P., McLaughlin, C., MacKenzie, A.R., Dundas, S., Ziglam, H., Douglas, E., Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Antimicrobial Audit Tool (GAAT) (2007) International Journal of Antimicrobial Agents, 29 (6), pp. 693-699. , DOI 10.1016/j.ijantimicag.2006.10.020, PII S092485790700091X; Ansari, F., The european surveillance of antimicrobial consumption (ESAC) point-prevalence survey of antibacterial use in 20 european hospitals in 2006 (2009) Clinical Infectious Diseases, 49, pp. 1496-1504; Vander Stichele, R.H., Elseviers, M.M., Ferech, M., Blot, S., Goossens, H., European Surveillance of Antimicrobial Consumption (ESAC): Data collection performance and methodological approach (2004) British Journal of Clinical Pharmacology, 58 (4), pp. 419-428. , DOI 10.1111/j.1365-2125.2004.02164.x; MacDougall, C., Polk, R.E., Variability in rates of use of antibacterials among 130 US hospitals and risk-adjustment models for interhospital comparison (2008) Infection Control and Hospital Epidemiology, 29 (3), pp. 203-211. , DOI 10.1086/528810; Aldeyab, M.A., Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant staphylococcus aureus: A time-series analysis (2008) Journal of Antimicrobial Chemotherapy, 62, pp. 593-600; Aldeyab, M.A., Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of clostridium difficile-associated diarrhea in hospitalized patients (2009) Antimicrobial Agents and Chemotherapy, 53, pp. 2082-2088; Zarb, P., Goossens, H., European surveillance of antimicrobial consumption (ESAC): Value of a point-prevalence survey of antimicrobial use across europe (2011) Drugs, 71, pp. 745-755; Davey, P., Interventions to improve antibiotic prescribing practices for hospital inpatients (2005) Cochrane Database of Systematic Reviews, (4). , Art No CD003543",

year = "2012",

month = sep,

doi = "10.1017/S095026881100241X",

language = "English",

volume = "140",

pages = "1714--1720",

journal = "Epidemiology and Infection",

issn = "0950-2688",

publisher = "Cambridge University Press",

number = "9",

}

Aldeyab, MA, Kearney, MP, McElnay, JC, Magee, FA, Conlon, G, MacIntyre, J, McCullagh, B, Ferguson, C, Friel, A, Gormley, C, McElroy, S, Boyce, T, McCorry, A, Muller, A, Goossens, H & Scott, MG 2012, 'A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool', Epidemiology and Infection, vol. 140, no. 9, pp. 1714-1720. https://doi.org/10.1017/S095026881100241X

TY - JOUR

T1 - A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool

AU - Aldeyab, M.A.

AU - Kearney, M.P.

AU - McElnay, J.C.

AU - Magee, F.A.

AU - Conlon, G.

AU - MacIntyre, J.

AU - McCullagh, B.

AU - Ferguson, C.

AU - Friel, A.

AU - Gormley, C

AU - McElroy, S.

AU - Boyce, T.

AU - McCorry, A.

AU - Muller, A.

AU - Goossens, H.

AU - Scott, M.G.

N1 - Cited By :7 Export Date: 15 September 2018 CODEN: EPINE Correspondence Address: Aldeyab, M.A.; Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast/Pharmacy, Belfast BT9 7BL, United Kingdom; email: [email protected] Chemicals/CAS: amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; ciprofloxacin, 85721-33-1; clarithromycin, 81103-11-9; lincosamide, 80738-43-8; metronidazole, 39322-38-8, 443-48-1; teicoplanin, 61036-62-2, 61036-64-4; trimethoprim, 738-70-5; vancomycin, 1404-90-6, 1404-93-9; Anti-Bacterial Agents References: Gyssens, I.C., Quality measures of antimicrobial drug use (2001) International Journal of Antimicrobial Agents, 17 (1), pp. 9-19. , DOI 10.1016/S0924-8579(00)00208-9, PII S0924857900002089; Paterson, D.L., The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals (2006) Clinical Infectious Diseases, 42 (SUPPL. 2), pp. S90-95; Smith, S.V., Gould, I.M., Optimization of antibiotic dosing schedules in the light of increasing antibiotic resistance (2004) Expert Review of Anti-Infective Therapy, 2 (2), pp. 227-234. , DOI 10.1586/14737140.2.2.227; MacDougall, C., Polk, R.E., Antimicrobial stewardship programs in health care systems (2005) Clinical Microbiology Reviews, 18 (4), pp. 638-656. , DOI 10.1128/CMR.18.4.638-656.2005; Aldeyab, M.A., A point prevalence survey of antibiotic prescriptions: Benchmarking and patterns of use (2010) British Journal of Clinical Pharmacology, 71, pp. 293-296; Seaton, R.A., Nathwani, D., Burton, P., McLaughlin, C., MacKenzie, A.R., Dundas, S., Ziglam, H., Douglas, E., Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Antimicrobial Audit Tool (GAAT) (2007) International Journal of Antimicrobial Agents, 29 (6), pp. 693-699. , DOI 10.1016/j.ijantimicag.2006.10.020, PII S092485790700091X; Ansari, F., The european surveillance of antimicrobial consumption (ESAC) point-prevalence survey of antibacterial use in 20 european hospitals in 2006 (2009) Clinical Infectious Diseases, 49, pp. 1496-1504; Vander Stichele, R.H., Elseviers, M.M., Ferech, M., Blot, S., Goossens, H., European Surveillance of Antimicrobial Consumption (ESAC): Data collection performance and methodological approach (2004) British Journal of Clinical Pharmacology, 58 (4), pp. 419-428. , DOI 10.1111/j.1365-2125.2004.02164.x; MacDougall, C., Polk, R.E., Variability in rates of use of antibacterials among 130 US hospitals and risk-adjustment models for interhospital comparison (2008) Infection Control and Hospital Epidemiology, 29 (3), pp. 203-211. , DOI 10.1086/528810; Aldeyab, M.A., Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant staphylococcus aureus: A time-series analysis (2008) Journal of Antimicrobial Chemotherapy, 62, pp. 593-600; Aldeyab, M.A., Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of clostridium difficile-associated diarrhea in hospitalized patients (2009) Antimicrobial Agents and Chemotherapy, 53, pp. 2082-2088; Zarb, P., Goossens, H., European surveillance of antimicrobial consumption (ESAC): Value of a point-prevalence survey of antimicrobial use across europe (2011) Drugs, 71, pp. 745-755; Davey, P., Interventions to improve antibiotic prescribing practices for hospital inpatients (2005) Cochrane Database of Systematic Reviews, (4). , Art No CD003543

PY - 2012/9

Y1 - 2012/9

N2 - The objective of this research was to assess current patterns of hospital antibiotic prescribing in Northern Ireland and to determine targets for improving the quality of antibiotic prescribing. A point prevalence survey was conducted in four acute teaching hospitals. The most commonly used antibiotics were combinations of penicillins including β-lactamase inhibitors (33.6%), metronidazole (9.1%), and macrolides (8.1%). The indication for treatment was recorded in 84.3% of the prescribing episodes. A small fraction (3.9%) of the surgical prophylactic antibiotic prescriptions was for >24 h. The results showed that overall 52.4% of the prescribed antibiotics were in compliance with the hospital antibiotic guidelines. The findings identified the following indicators as targets for quality improvement: indication recorded in patient notes, the duration of surgical prophylaxis and compliance with hospital antibiotic guidelines. The results strongly suggest that antibiotic use could be improved by taking steps to address the identified targets for quality improvement. © 2011 Cambridge University Press.

AB - The objective of this research was to assess current patterns of hospital antibiotic prescribing in Northern Ireland and to determine targets for improving the quality of antibiotic prescribing. A point prevalence survey was conducted in four acute teaching hospitals. The most commonly used antibiotics were combinations of penicillins including β-lactamase inhibitors (33.6%), metronidazole (9.1%), and macrolides (8.1%). The indication for treatment was recorded in 84.3% of the prescribing episodes. A small fraction (3.9%) of the surgical prophylactic antibiotic prescriptions was for >24 h. The results showed that overall 52.4% of the prescribed antibiotics were in compliance with the hospital antibiotic guidelines. The findings identified the following indicators as targets for quality improvement: indication recorded in patient notes, the duration of surgical prophylaxis and compliance with hospital antibiotic guidelines. The results strongly suggest that antibiotic use could be improved by taking steps to address the identified targets for quality improvement. © 2011 Cambridge University Press.

KW - Antibiotic use

KW - ESAC

KW - point prevalence surveys

KW - quality improvement

KW - aminoglycoside antibiotic agent

KW - amoxicillin plus clavulanic acid

KW - antibiotic agent

KW - beta lactamase inhibitor

KW - carbapenem derivative

KW - cephalosporin derivative

KW - ciprofloxacin

KW - clarithromycin

KW - imidazole derivative

KW - lincosamide

KW - macrolide

KW - metronidazole

KW - monobactam derivative

KW - nitrofuran derivative

KW - penicillin derivative

KW - piperacillin plus tazobactam

KW - quinoline derived antiinfective agent

KW - steroid

KW - sulfonamide

KW - teicoplanin

KW - tetracycline derivative

KW - trimethoprim

KW - trimethoprim derivative

KW - vancomycin

KW - adult

KW - aged

KW - antibiotic prophylaxis

KW - article

KW - community acquired infection

KW - drug use

KW - female

KW - health care quality

KW - health survey

KW - hospital infection

KW - human

KW - infection

KW - Ireland

KW - major clinical study

KW - male

KW - medical audit

KW - point prevalence survey

KW - postoperative infection

KW - practice guideline

KW - prescription

KW - teaching hospital

KW - treatment duration

KW - treatment indication

KW - Aged

KW - Aged, 80 and over

KW - Anti-Bacterial Agents

KW - Drug Prescriptions

KW - Drug Utilization Review

KW - Female

KW - Guideline Adherence

KW - Health Care Surveys

KW - Hospitals, Teaching

KW - Humans

KW - Male

KW - Middle Aged

KW - Northern Ireland

U2 - 10.1017/S095026881100241X

DO - 10.1017/S095026881100241X

M3 - Article

SN - 0950-2688

VL - 140

SP - 1714

EP - 1720

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 9

ER -

A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool

Abstract

Bibliographical note

Keywords

UN SDGs

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Cite this