A Point-of-Care Measurement of NT-proBNP for Heart Failure Patients

Cesar Navarro-Paredes; Sam Fishlock; David Steele; Srinivasu Puttaswamy; Gennady Lubarsky; Shasidran Raj; James McLaughlin

doi:10.1109/ACCESS.2020.3007988

A Point-of-Care Measurement of NT-proBNP for Heart Failure Patients

Cesar Navarro-Paredes, Sam Fishlock, David Steele, Srinivasu Puttaswamy, Gennady Lubarsky, Shasidran Raj, James McLaughlin

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

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Abstract

Heart Failure (HF) diagnosis, subsequent admissions, and possible readmissions present challenges for health systems worldwide. An increasing number of patients within an ageing population are surviving cardiac conditions which can leave them with residual heart function impairment. Follow-up visits of either confirmed HF sufferers or HF high-risk patients could be reduced through the implementation of Point-of-Care (PoC) measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP), an inactive signal portion of the active hormone BNP that is released in response to cardiac wall stretch. Serial measurements of NT-proBNP concentration may serve to indicate progress/deterioration of HF sufferers which in turn indicates the quality of the interventions designed to treat HF. We present an integrated PoC solution that involves the user-friendly, low volume sampling of blood directly into a single-use sampling key with an integral NT-proBNP biomarker detection strip operating on a lateral flow immunoassay principle. When inserted into a corresponding portable electronic reader it forms an integrated detection and measurement platform that wirelessly communicates measurements (Wi-Fi) for cloud-based reporting, trending and data analysis. The system provides a practical, inexpensive support tool for HF management by informing those involved in clinical decision-making with necessary biomarker data. The PoC NT-proBNP measurement compares well against alternative technologies based on image analysis.

Original language	English
Article number	9136694
Pages (from-to)	138973 - 138983
Number of pages	11
Journal	IEEE Access
Volume	8
DOIs	https://doi.org/10.1109/ACCESS.2020.3007988
Publication status	Published - 8 Jul 2020

Bibliographical note

Funding Information:
The authors thank the financial support of Invest Northern Ireland through the Connected Health and Innovation Centre (CHIC), project number RD0513853 and the Eastern Corridor for Medical Engineering Centre (ECME) funded by the European Union's Interreg VA Programme which is managed by the Special EU Programmes Body (SEUPB).

Publisher Copyright:
© 2013 IEEE.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Heart failure interventions
NT-proBNP
lateral flow immunoassay
low volume blood sampling
point-of-care

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10.1109/ACCESS.2020.3007988Licence: CC BY

ACCESS3007988_final_version_publishedFinal published version, 1.56 MBLicence: CC BY

Cite this

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title = "A Point-of-Care Measurement of NT-proBNP for Heart Failure Patients",

abstract = "Heart Failure (HF) diagnosis, subsequent admissions, and possible readmissions present challenges for health systems worldwide. An increasing number of patients within an ageing population are surviving cardiac conditions which can leave them with residual heart function impairment. Follow-up visits of either confirmed HF sufferers or HF high-risk patients could be reduced through the implementation of Point-of-Care (PoC) measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP), an inactive signal portion of the active hormone BNP that is released in response to cardiac wall stretch. Serial measurements of NT-proBNP concentration may serve to indicate progress/deterioration of HF sufferers which in turn indicates the quality of the interventions designed to treat HF. We present an integrated PoC solution that involves the user-friendly, low volume sampling of blood directly into a single-use sampling key with an integral NT-proBNP biomarker detection strip operating on a lateral flow immunoassay principle. When inserted into a corresponding portable electronic reader it forms an integrated detection and measurement platform that wirelessly communicates measurements (Wi-Fi) for cloud-based reporting, trending and data analysis. The system provides a practical, inexpensive support tool for HF management by informing those involved in clinical decision-making with necessary biomarker data. The PoC NT-proBNP measurement compares well against alternative technologies based on image analysis.",

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author = "Cesar Navarro-Paredes and Sam Fishlock and David Steele and Srinivasu Puttaswamy and Gennady Lubarsky and Shasidran Raj and James McLaughlin",

note = "Funding Information: The authors thank the financial support of Invest Northern Ireland through the Connected Health and Innovation Centre (CHIC), project number RD0513853 and the Eastern Corridor for Medical Engineering Centre (ECME) funded by the European Union's Interreg VA Programme which is managed by the Special EU Programmes Body (SEUPB). Publisher Copyright: {\textcopyright} 2013 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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AU - Raj, Shasidran

AU - McLaughlin, James

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N2 - Heart Failure (HF) diagnosis, subsequent admissions, and possible readmissions present challenges for health systems worldwide. An increasing number of patients within an ageing population are surviving cardiac conditions which can leave them with residual heart function impairment. Follow-up visits of either confirmed HF sufferers or HF high-risk patients could be reduced through the implementation of Point-of-Care (PoC) measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP), an inactive signal portion of the active hormone BNP that is released in response to cardiac wall stretch. Serial measurements of NT-proBNP concentration may serve to indicate progress/deterioration of HF sufferers which in turn indicates the quality of the interventions designed to treat HF. We present an integrated PoC solution that involves the user-friendly, low volume sampling of blood directly into a single-use sampling key with an integral NT-proBNP biomarker detection strip operating on a lateral flow immunoassay principle. When inserted into a corresponding portable electronic reader it forms an integrated detection and measurement platform that wirelessly communicates measurements (Wi-Fi) for cloud-based reporting, trending and data analysis. The system provides a practical, inexpensive support tool for HF management by informing those involved in clinical decision-making with necessary biomarker data. The PoC NT-proBNP measurement compares well against alternative technologies based on image analysis.

AB - Heart Failure (HF) diagnosis, subsequent admissions, and possible readmissions present challenges for health systems worldwide. An increasing number of patients within an ageing population are surviving cardiac conditions which can leave them with residual heart function impairment. Follow-up visits of either confirmed HF sufferers or HF high-risk patients could be reduced through the implementation of Point-of-Care (PoC) measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP), an inactive signal portion of the active hormone BNP that is released in response to cardiac wall stretch. Serial measurements of NT-proBNP concentration may serve to indicate progress/deterioration of HF sufferers which in turn indicates the quality of the interventions designed to treat HF. We present an integrated PoC solution that involves the user-friendly, low volume sampling of blood directly into a single-use sampling key with an integral NT-proBNP biomarker detection strip operating on a lateral flow immunoassay principle. When inserted into a corresponding portable electronic reader it forms an integrated detection and measurement platform that wirelessly communicates measurements (Wi-Fi) for cloud-based reporting, trending and data analysis. The system provides a practical, inexpensive support tool for HF management by informing those involved in clinical decision-making with necessary biomarker data. The PoC NT-proBNP measurement compares well against alternative technologies based on image analysis.

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A Point-of-Care Measurement of NT-proBNP for Heart Failure Patients

Abstract

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Keywords

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