A novel human stress response-related gene with a potential role in induced radioresistance

T Robson, MC Joiner, GD Wilson, William McCullough, ME Price, Ian Logan, H Jones, Stephanie McKeown, DG Hirst

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    We have isolated a novel gene, DIR1, from L132 cells that is transiently repressed after exposure to low radiation doses and has a potential role in induced radioresistance, Molecular and cellular characterization of this gene reveals that it is unique but has similarities to a family of heat-shock-related proteins known as immunophilins. These have been implicated in various cellular functions including general stress responses and control of the cell cycle. Antisense strategies have demonstrated that the DIR1 gene also appears to have some involvement in the control of the cell cycle. Furthermore, there appears be a potential role for this gene product in the phenomenon of induced radioresistance through a mechanism that increases the rate of DNA repair in cells exposed to X rays and subsequently increases the cells' resistance to radiation. This is the first description of an immunophilin-like gene that has a possible role in adaptive/inducible responses to X rays in mammalian cells. (C) 1999 by Radiation Research Society.
    LanguageEnglish
    Pages451-461
    JournalRadiation Research
    Volume152
    Issue number5
    Publication statusPublished - Nov 1999

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    Immunophilins
    Genes
    Cell Cycle Checkpoints
    X-Rays
    Radiation
    Heat-Shock Proteins
    DNA Repair

    Cite this

    Robson, T., Joiner, MC., Wilson, GD., McCullough, W., Price, ME., Logan, I., ... Hirst, DG. (1999). A novel human stress response-related gene with a potential role in induced radioresistance. Radiation Research, 152(5), 451-461.
    Robson, T ; Joiner, MC ; Wilson, GD ; McCullough, William ; Price, ME ; Logan, Ian ; Jones, H ; McKeown, Stephanie ; Hirst, DG. / A novel human stress response-related gene with a potential role in induced radioresistance. In: Radiation Research. 1999 ; Vol. 152, No. 5. pp. 451-461.
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    abstract = "We have isolated a novel gene, DIR1, from L132 cells that is transiently repressed after exposure to low radiation doses and has a potential role in induced radioresistance, Molecular and cellular characterization of this gene reveals that it is unique but has similarities to a family of heat-shock-related proteins known as immunophilins. These have been implicated in various cellular functions including general stress responses and control of the cell cycle. Antisense strategies have demonstrated that the DIR1 gene also appears to have some involvement in the control of the cell cycle. Furthermore, there appears be a potential role for this gene product in the phenomenon of induced radioresistance through a mechanism that increases the rate of DNA repair in cells exposed to X rays and subsequently increases the cells' resistance to radiation. This is the first description of an immunophilin-like gene that has a possible role in adaptive/inducible responses to X rays in mammalian cells. (C) 1999 by Radiation Research Society.",
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    Robson, T, Joiner, MC, Wilson, GD, McCullough, W, Price, ME, Logan, I, Jones, H, McKeown, S & Hirst, DG 1999, 'A novel human stress response-related gene with a potential role in induced radioresistance', Radiation Research, vol. 152, no. 5, pp. 451-461.

    A novel human stress response-related gene with a potential role in induced radioresistance. / Robson, T; Joiner, MC; Wilson, GD; McCullough, William; Price, ME; Logan, Ian; Jones, H; McKeown, Stephanie; Hirst, DG.

    In: Radiation Research, Vol. 152, No. 5, 11.1999, p. 451-461.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - A novel human stress response-related gene with a potential role in induced radioresistance

    AU - Robson, T

    AU - Joiner, MC

    AU - Wilson, GD

    AU - McCullough, William

    AU - Price, ME

    AU - Logan, Ian

    AU - Jones, H

    AU - McKeown, Stephanie

    AU - Hirst, DG

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    N2 - We have isolated a novel gene, DIR1, from L132 cells that is transiently repressed after exposure to low radiation doses and has a potential role in induced radioresistance, Molecular and cellular characterization of this gene reveals that it is unique but has similarities to a family of heat-shock-related proteins known as immunophilins. These have been implicated in various cellular functions including general stress responses and control of the cell cycle. Antisense strategies have demonstrated that the DIR1 gene also appears to have some involvement in the control of the cell cycle. Furthermore, there appears be a potential role for this gene product in the phenomenon of induced radioresistance through a mechanism that increases the rate of DNA repair in cells exposed to X rays and subsequently increases the cells' resistance to radiation. This is the first description of an immunophilin-like gene that has a possible role in adaptive/inducible responses to X rays in mammalian cells. (C) 1999 by Radiation Research Society.

    AB - We have isolated a novel gene, DIR1, from L132 cells that is transiently repressed after exposure to low radiation doses and has a potential role in induced radioresistance, Molecular and cellular characterization of this gene reveals that it is unique but has similarities to a family of heat-shock-related proteins known as immunophilins. These have been implicated in various cellular functions including general stress responses and control of the cell cycle. Antisense strategies have demonstrated that the DIR1 gene also appears to have some involvement in the control of the cell cycle. Furthermore, there appears be a potential role for this gene product in the phenomenon of induced radioresistance through a mechanism that increases the rate of DNA repair in cells exposed to X rays and subsequently increases the cells' resistance to radiation. This is the first description of an immunophilin-like gene that has a possible role in adaptive/inducible responses to X rays in mammalian cells. (C) 1999 by Radiation Research Society.

    M3 - Article

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    Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I et al. A novel human stress response-related gene with a potential role in induced radioresistance. Radiation Research. 1999 Nov;152(5):451-461.