Abstract
Chitosan's poor solubility especially in organic solvents limits its use with other organo-soluble polymers; however such combinations are highly required to tailor their properties for specific biomedical applications. This paper describes the development of a new synthetic methodology for the synthesis of organo-soluble chitosan derivatives. These derivatives were synthesized from chitosan (CS), triethyl orthoformate and barbituric or thiobarbituric acid in the presence of 2-butannol. The chemical interactions and new functional motifs in the synthesized CS derivatives were evaluated by FTIR, DSC/TGA, UV/VIS, XRD and 1H NMR spectroscopy. A cytotoxicity investigation for these materials was performed by cell culture method using VERO cell line and all the synthesized derivatives were found to be non-toxic. The solubility analysis showed that these derivatives were readily soluble in organic solvents including DMSO and DMF. Their potential to use with organo-soluble commercially available polymers was exploited by electrospinning; the synthesized derivatives in combination with polycaprolactone delivered nanofibrous membranes.
Original language | English |
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Pages (from-to) | 156-163 |
Number of pages | 8 |
Journal | Materials Science and Engineering: C |
Volume | 66 |
Early online date | 20 Apr 2016 |
DOIs | |
Publication status | Published (in print/issue) - 1 Sept 2016 |
Keywords
- Chitosan derivatives
- Organo-soluble
- Synthetic method
- Vero cells
- Triethylorthoformate