A Narrative Review of the Anti-Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Shaun Sharkey, PA Harnedy-Rothwell, Philip J Allsopp, L.E. Hollywood, R Fitzgerald, Finbarr O'Harte

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)
90 Downloads (Pure)


Prevalence of type 2 diabetes and overweight/obesity are increasing globally.Food supplementation as a preventative option has become an attractive option in comparison to increased pharmacotherapy dependency. Hydrolysates of fish processing waste and by-products have become particularly interesting in a climate of increased food wastage awareness and are rapidly gaining traction in food research. This review summarizes the available research so far on the potential effect of these hydrolysates ondiabetes and appetite suppression. Scopus and Web of Science are searched using eight keywords (fish, hydrolysate, peptides, satiating, insulinotropic,incretin, anti-obesity, DPP-4 [dipeptidylpeptidase-4/IV]) returning a total of 2549 results. Following exclusion criteria (repeated appearances, non-fish marine sources [e.g., macroalgae], and irrelevant bioactivities [e.g.,immunomodulatory, anti-thrombotic]), 44 relevant publications are includedin this review. Stimulation of hormone secretion, regulation of glucose uptake,anorexigenic potential, identified mechanisms of action, and research conducted on the most potent bioactive peptides identified within these hydrolysates are all specifically addressed. Results of this review conclude that despite wide methodological variation between studies, there is significant potential for the application of fish protein hydrolysates in the management of body weight and hyperglycemia.
Original languageEnglish
Article number2000403
Pages (from-to)1-10
Number of pages10
JournalMolecular Nutrition and Food Research
Issue number21
Early online date16 Sept 2020
Publication statusPublished (in print/issue) - 4 Nov 2020

Bibliographical note

Funding Information:
S.J.S. is funded by a Northern Ireland Department of Education and Learning PhD scholarship and P.A.H.-R. is funded under the National Development Plan 2007?2013, through the Food Institutional Research Measure (FIRM), administered by the Department of Agriculture, Food and Marine, Ireland under grant issue 17/F/260, respectively.

Publisher Copyright:
© 2020 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH

Copyright 2020 Elsevier B.V., All rights reserved.


  • fish
  • hydrolysate
  • peptides
  • satiating
  • insulinotropic
  • incretin
  • anti-obesity
  • DPP-4 [dipeptidylpeptidase-4/IV])
  • IV
  • bioactive peptides
  • anorexigenic
  • fish hydrolysate
  • anti-diabetic
  • dipeptidylpeptidase-4
  • dipeptidylpeptidase-4/IV


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