A mechanistic evaluation of the amperometric response of reduced thiols in quinone mediated systems

CG Stone, MF Cardosi, J Davis

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.
    LanguageEnglish
    Pages203-210
    JournalAnalytica Chimica Acta
    Volume491
    Issue number2
    DOIs
    Publication statusPublished - Sep 2003

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    Sulfhydryl Compounds
    Electrodes
    Stoichiometry
    Glutathione
    Cysteine
    Sensors
    benzoquinone

    Cite this

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    abstract = "The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.",
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    A mechanistic evaluation of the amperometric response of reduced thiols in quinone mediated systems. / Stone, CG; Cardosi, MF; Davis, J.

    In: Analytica Chimica Acta, Vol. 491, No. 2, 09.2003, p. 203-210.

    Research output: Contribution to journalArticle

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    AB - The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.

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