A mechanistic evaluation of the amperometric response of reduced thiols in quinone mediated systems

CG Stone; MF Cardosi; J Davis

doi:10.1016/S0003-2670(03)00765-7

A mechanistic evaluation of the amperometric response of reduced thiols in quinone mediated systems

CG Stone, MF Cardosi, J Davis

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	203-210
Journal	Analytica Chimica Acta
Volume	491
Issue number	2
DOIs	https://doi.org/10.1016/S0003-2670(03)00765-7
Publication status	Published - Sep 2003

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abstract = "The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.",

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AB - The specificity of the reaction of benzoquinone with reduced thiol species has been investigated and the nature of the amperometric electrode response elucidated. The analytical applicability of the methodology has been assessed and it has been shown that through appropriate selection of the redox properties of the indicating quinone, interference from other electroactive species can be minimised. A discrepancy in the reaction stoichiometry has however been found between the glutathione and cysteine quinone adducts and the implications in interpreting the resulting sensor response are rationalised. The adaptation of the approach to disposable, screen printed electrode assemblies has been investigated. (C) 2003 Elsevier B.V. All rights reserved.

U2 - 10.1016/S0003-2670(03)00765-7

DO - 10.1016/S0003-2670(03)00765-7

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