A Critical Review for Advances on Industrialization of Immobilized Cell Bioreactors: Economic Evaluation on Cellulose Hydrolysis for PHB Production

Konstantina Boura, Agapi Dima, Poonam Singh - Nee Nigam, Vassilios Panagopoulos, Maria Kanellaki, A.A. Koutinas

Research output: Contribution to journalReview articlepeer-review

Abstract

Advances such as cell-on-cell immobilization, multi-stage fixed bed tower (MFBT) bioreactor, promotional effect on fermentation, extremely low temperature fermentation, freeze dried immobilized cells in two-layer fermentation, non-engineered cell factories, and those of recent papers are demonstrated. Studies for possible industrialization of ICB, considering production capacity, low temperatures fermentations, added value products and bulk chemical production are studied. Immobilized cell bioreactors (ICB) using cellulose nano-biotechnology and engineered cells are reported. The development of a novel ICB with recent advances on high added value products and conceptual research areas for industrialization of ICB is proposed. The isolation of engineered flocculant cells leads to a single tank ICB. The concept of cell factories without GMO is a new research area. The conceptual development of multi-stage fixed bed tower membrane (MFBTM) ICB is discussed. Finally, feasible process design and technoeconomic analysis of cellulose hydrolysis using ICB are studied for polyhydroxybutyrate (PHB) production.
Original languageEnglish
Article number126757
JournalBioresource Technology
Volume349
Early online date22 Jan 2022
DOIs
Publication statusPublished - 30 Apr 2022

Bibliographical note

Funding Information:
Authors acknowledge the support of this work by the project “Research Infrastructure on Food Bioprocessing Development and Innovation Exploitation – Food Innovation RI” (MIS 5027222), which is implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Biocatalysts
  • Bioreactors
  • industrialization
  • Immobilized-Cell-Bioreactors
  • polyhydroxybutyrate
  • Industrialization
  • Polyhydroxybutyrate

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