A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
LanguageEnglish
Pages56-66
JournalBIiochemical Pharmacology
Volume86
Issue number1
DOIs
Publication statusPublished - 2013

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Systems Biology
Cholesterol
Biological Phenomena
Mevalonic Acid
Health
24,25-epoxycholesterol

Keywords

  • Cholesterol
  • Sterol
  • SBGN
  • Metabolic Network
  • Pathway Map

Cite this

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title = "A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)",
abstract = "Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.",
keywords = "Cholesterol, Sterol, SBGN, Metabolic Network, Pathway Map",
author = "Steven Watterson",
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A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press). / Watterson, Steven.

Vol. 86, No. 1, 2013, p. 56-66.

Research output: Contribution to journalArticle

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AU - Watterson, Steven

N1 - Alexander Mazein and Steven Watterson are joint first authors.

PY - 2013

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N2 - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

AB - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

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KW - Sterol

KW - SBGN

KW - Metabolic Network

KW - Pathway Map

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