A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
Original languageEnglish
Pages (from-to)56-66
JournalBiochemical Pharmacology
Volume86
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Cholesterol
  • Sterol
  • SBGN
  • Metabolic Network
  • Pathway Map

Fingerprint Dive into the research topics of 'A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)'. Together they form a unique fingerprint.

  • Cite this