A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)

Steven Watterson

doi:10.1016/j.bcp.2013.03.021

A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)

Steven Watterson

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

Original language	English
Pages (from-to)	56-66
Journal	Biochemical Pharmacology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.bcp.2013.03.021
Publication status	Published - 2013

Keywords

Cholesterol
Sterol
SBGN
Metabolic Network
Pathway Map

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10.1016/j.bcp.2013.03.021

http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271311&_user=809099&_pii=S0006295213002219&_check=y&_origin=article&_zone=toolbar&_coverDate=10-Apr-2013&view=c&originContentFamily=serial&wchp=dGLzVBA-zSkWA&md5=af2a100f698ed29f4dfb75d3da4550a6&pid=1-s2.0-S0006295213002219-main.pdf

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abstract = "Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.",

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AB - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

KW - Cholesterol

KW - Sterol

KW - SBGN

KW - Metabolic Network

KW - Pathway Map

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JF - Biochemical Pharmacology

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