Abstract
Language | English |
---|---|
Pages | 56-66 |
Journal | BIiochemical Pharmacology |
Volume | 86 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2013 |
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Keywords
- Cholesterol
- Sterol
- SBGN
- Metabolic Network
- Pathway Map
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A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press). / Watterson, Steven.
In: BIiochemical Pharmacology, Vol. 86, No. 1, 2013, p. 56-66.Research output: Contribution to journal › Article
TY - JOUR
T1 - A comprehensive, machine readable view of the mammalian cholesterol biosynthesis pathway (in press)
AU - Watterson, Steven
N1 - Alexander Mazein and Steven Watterson are joint first authors.
PY - 2013
Y1 - 2013
N2 - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
AB - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
KW - Cholesterol
KW - Sterol
KW - SBGN
KW - Metabolic Network
KW - Pathway Map
U2 - 10.1016/j.bcp.2013.03.021
DO - 10.1016/j.bcp.2013.03.021
M3 - Article
VL - 86
SP - 56
EP - 66
JO - BIiochemical Pharmacology
T2 - BIiochemical Pharmacology
JF - BIiochemical Pharmacology
SN - 0006-2952
IS - 1
ER -