A comparative study of optical coherence tomography and slit-lamp based grading of cataract

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose : Established methods of grading cataract are susceptible to error due to their subjective nature as well as variation in slit-lamp settings during assessment. Furthermore, grading systems such as the Lens Opacities Classification System III (LOCS III) are only applicable to age-related forms of the condition. Optical coherence tomography (OCT) offers the potential to provide an objective method of imaging and grading all forms of cataract. An observational clinical study was performed to compare anterior segment OCT imaging with traditional, slit-lamp based grading. Methods : Crystalline lens images of 60 eyes from 38 adults aged 50 to 79 years (mean 62.97+/-9.99) were captured using a Nikon FS-3 slit-lamp photo-biomicroscope and a Zeiss Visante anterior segment OCT. Prior to imaging, participants were assessed for habitual visual acuity (logMAR), contrast sensitivity (Pelli-Robson) and straylight scatter (Oculus C-Quant). Pupils were then dilated with 1% tropicamide to obtain optimum images of the crystalline lens. The slit-lamp images were graded for age-related cataract (nuclear colour and opalescence) using the LOCS III. Raw OCT data were analysed in MATLAB to determine a pixel intensity ratio for the nucleus of each crystalline lens (see figure). Linear regression compared LOCS III nuclear opalescence and nuclear colour scores to OCT pixel intensity ratios. Results : Age-related nuclear cataract was the predominant cataract type, with LOCS III mean scores of 2.04+/-0.63 for nuclear opalescence and 1.65+/-0.71 for nuclear colour. Cortical and posterior subcapsular cataract were present at low levels (0.32+/-0.51; 0.12+/-0.12 respectively). Mean OCT nuclear pixel intensity ratio was 1.077+/-0.04. Regression analyses revealed significant relations between pixel intensity ratio and nuclear opalescence (F(1,58)=8.24, p
LanguageEnglish
Title of host publicationUnknown Host Publication
Number of pages2516
Volume57
Publication statusE-pub ahead of print - Sep 2016
EventAssociation for Research in Vision and Ophthalmology - United States of America
Duration: 1 Sep 2016 → …

Conference

ConferenceAssociation for Research in Vision and Ophthalmology
Period1/09/16 → …

Fingerprint

Optical Coherence Tomography
Cataract
Crystalline Lens
Color
Crystalline Lens Nucleus
Tropicamide
Contrast Sensitivity
Slit Lamp
Pupil
Visual Acuity
Observational Studies
Linear Models
Regression Analysis
Iridescence

Keywords

  • cataract
  • ocular coherence tomography (OCT)
  • slit lamp
  • LOCS III grading

Cite this

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title = "A comparative study of optical coherence tomography and slit-lamp based grading of cataract",
abstract = "Purpose : Established methods of grading cataract are susceptible to error due to their subjective nature as well as variation in slit-lamp settings during assessment. Furthermore, grading systems such as the Lens Opacities Classification System III (LOCS III) are only applicable to age-related forms of the condition. Optical coherence tomography (OCT) offers the potential to provide an objective method of imaging and grading all forms of cataract. An observational clinical study was performed to compare anterior segment OCT imaging with traditional, slit-lamp based grading. Methods : Crystalline lens images of 60 eyes from 38 adults aged 50 to 79 years (mean 62.97+/-9.99) were captured using a Nikon FS-3 slit-lamp photo-biomicroscope and a Zeiss Visante anterior segment OCT. Prior to imaging, participants were assessed for habitual visual acuity (logMAR), contrast sensitivity (Pelli-Robson) and straylight scatter (Oculus C-Quant). Pupils were then dilated with 1{\%} tropicamide to obtain optimum images of the crystalline lens. The slit-lamp images were graded for age-related cataract (nuclear colour and opalescence) using the LOCS III. Raw OCT data were analysed in MATLAB to determine a pixel intensity ratio for the nucleus of each crystalline lens (see figure). Linear regression compared LOCS III nuclear opalescence and nuclear colour scores to OCT pixel intensity ratios. Results : Age-related nuclear cataract was the predominant cataract type, with LOCS III mean scores of 2.04+/-0.63 for nuclear opalescence and 1.65+/-0.71 for nuclear colour. Cortical and posterior subcapsular cataract were present at low levels (0.32+/-0.51; 0.12+/-0.12 respectively). Mean OCT nuclear pixel intensity ratio was 1.077+/-0.04. Regression analyses revealed significant relations between pixel intensity ratio and nuclear opalescence (F(1,58)=8.24, p",
keywords = "cataract, ocular coherence tomography (OCT), slit lamp, LOCS III grading",
author = "Aman-Deep Mahil and Saunders, {Kathryn J} and Patrick Richardson and Julie-Anne Little",
year = "2016",
month = "9",
language = "English",
volume = "57",
booktitle = "Unknown Host Publication",

}

Mahil, A-D, Saunders, KJ, Richardson, P & Little, J-A 2016, A comparative study of optical coherence tomography and slit-lamp based grading of cataract. in Unknown Host Publication. vol. 57, Association for Research in Vision and Ophthalmology, 1/09/16.

A comparative study of optical coherence tomography and slit-lamp based grading of cataract. / Mahil, Aman-Deep; Saunders, Kathryn J; Richardson, Patrick; Little, Julie-Anne.

Unknown Host Publication. Vol. 57 2016.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - A comparative study of optical coherence tomography and slit-lamp based grading of cataract

AU - Mahil, Aman-Deep

AU - Saunders, Kathryn J

AU - Richardson, Patrick

AU - Little, Julie-Anne

PY - 2016/9

Y1 - 2016/9

N2 - Purpose : Established methods of grading cataract are susceptible to error due to their subjective nature as well as variation in slit-lamp settings during assessment. Furthermore, grading systems such as the Lens Opacities Classification System III (LOCS III) are only applicable to age-related forms of the condition. Optical coherence tomography (OCT) offers the potential to provide an objective method of imaging and grading all forms of cataract. An observational clinical study was performed to compare anterior segment OCT imaging with traditional, slit-lamp based grading. Methods : Crystalline lens images of 60 eyes from 38 adults aged 50 to 79 years (mean 62.97+/-9.99) were captured using a Nikon FS-3 slit-lamp photo-biomicroscope and a Zeiss Visante anterior segment OCT. Prior to imaging, participants were assessed for habitual visual acuity (logMAR), contrast sensitivity (Pelli-Robson) and straylight scatter (Oculus C-Quant). Pupils were then dilated with 1% tropicamide to obtain optimum images of the crystalline lens. The slit-lamp images were graded for age-related cataract (nuclear colour and opalescence) using the LOCS III. Raw OCT data were analysed in MATLAB to determine a pixel intensity ratio for the nucleus of each crystalline lens (see figure). Linear regression compared LOCS III nuclear opalescence and nuclear colour scores to OCT pixel intensity ratios. Results : Age-related nuclear cataract was the predominant cataract type, with LOCS III mean scores of 2.04+/-0.63 for nuclear opalescence and 1.65+/-0.71 for nuclear colour. Cortical and posterior subcapsular cataract were present at low levels (0.32+/-0.51; 0.12+/-0.12 respectively). Mean OCT nuclear pixel intensity ratio was 1.077+/-0.04. Regression analyses revealed significant relations between pixel intensity ratio and nuclear opalescence (F(1,58)=8.24, p

AB - Purpose : Established methods of grading cataract are susceptible to error due to their subjective nature as well as variation in slit-lamp settings during assessment. Furthermore, grading systems such as the Lens Opacities Classification System III (LOCS III) are only applicable to age-related forms of the condition. Optical coherence tomography (OCT) offers the potential to provide an objective method of imaging and grading all forms of cataract. An observational clinical study was performed to compare anterior segment OCT imaging with traditional, slit-lamp based grading. Methods : Crystalline lens images of 60 eyes from 38 adults aged 50 to 79 years (mean 62.97+/-9.99) were captured using a Nikon FS-3 slit-lamp photo-biomicroscope and a Zeiss Visante anterior segment OCT. Prior to imaging, participants were assessed for habitual visual acuity (logMAR), contrast sensitivity (Pelli-Robson) and straylight scatter (Oculus C-Quant). Pupils were then dilated with 1% tropicamide to obtain optimum images of the crystalline lens. The slit-lamp images were graded for age-related cataract (nuclear colour and opalescence) using the LOCS III. Raw OCT data were analysed in MATLAB to determine a pixel intensity ratio for the nucleus of each crystalline lens (see figure). Linear regression compared LOCS III nuclear opalescence and nuclear colour scores to OCT pixel intensity ratios. Results : Age-related nuclear cataract was the predominant cataract type, with LOCS III mean scores of 2.04+/-0.63 for nuclear opalescence and 1.65+/-0.71 for nuclear colour. Cortical and posterior subcapsular cataract were present at low levels (0.32+/-0.51; 0.12+/-0.12 respectively). Mean OCT nuclear pixel intensity ratio was 1.077+/-0.04. Regression analyses revealed significant relations between pixel intensity ratio and nuclear opalescence (F(1,58)=8.24, p

KW - cataract

KW - ocular coherence tomography (OCT)

KW - slit lamp

KW - LOCS III grading

M3 - Conference contribution

VL - 57

BT - Unknown Host Publication

ER -