A clinical assessment of direct electrochemical urate measurements

JSN Dutt, C Livingstone, MF Cardosi, SJ Wilkins, J Davis

    Research output: Contribution to journal › Article

    6 Citations (Scopus)

    Abstract

    The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.
    LanguageEnglish
    Pages1463-1468
    JournalTalanta
    Volume68
    Issue number5
    DOIs
    Publication statusPublished - Feb 2006

    Fingerprint

    Uric Acid
    Urate Oxidase
    Biomarkers
    Substrates
    Peroxidase
    Laminates
    Assays
    Carbon
    Plasmas
    Fabrication
    Sensors
    carbon fiber
    purine

    Cite this

    Dutt, JSN., Livingstone, C., Cardosi, MF., Wilkins, SJ., & Davis, J. (2006). A clinical assessment of direct electrochemical urate measurements. Talanta, 68(5), 1463-1468. https://doi.org/10.1016/j.talanta.2005.08.020
    Dutt, JSN ; Livingstone, C ; Cardosi, MF ; Wilkins, SJ ; Davis, J. / A clinical assessment of direct electrochemical urate measurements. In: Talanta. 2006 ; Vol. 68, No. 5. pp. 1463-1468.
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    Dutt, JSN, Livingstone, C, Cardosi, MF, Wilkins, SJ & Davis, J 2006, 'A clinical assessment of direct electrochemical urate measurements', Talanta, vol. 68, no. 5, pp. 1463-1468. https://doi.org/10.1016/j.talanta.2005.08.020

    A clinical assessment of direct electrochemical urate measurements. / Dutt, JSN; Livingstone, C; Cardosi, MF; Wilkins, SJ; Davis, J.

    In: Talanta, Vol. 68, No. 5, 02.2006, p. 1463-1468.

    Research output: Contribution to journal › Article

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    AB - The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.

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    Dutt JSN, Livingstone C, Cardosi MF, Wilkins SJ, Davis J. A clinical assessment of direct electrochemical urate measurements. Talanta. 2006 Feb;68(5):1463-1468. https://doi.org/10.1016/j.talanta.2005.08.020

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