A clinical assessment of direct electrochemical urate measurements

JSN Dutt; C Livingstone; MF Cardosi; SJ Wilkins; J Davis

doi:10.1016/j.talanta.2005.08.020

A clinical assessment of direct electrochemical urate measurements

JSN Dutt, C Livingstone, MF Cardosi, SJ Wilkins, J Davis

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1463-1468
Journal	Talanta
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/j.talanta.2005.08.020
Publication status	Published (in print/issue) - Feb 2006

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10.1016/j.talanta.2005.08.020

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abstract = "The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.",

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AU - Dutt, JSN

AU - Livingstone, C

AU - Cardosi, MF

AU - Wilkins, SJ

AU - Davis, J

PY - 2006/2

Y1 - 2006/2

N2 - The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.

AB - The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.talanta.2005.08.020

DO - 10.1016/j.talanta.2005.08.020

M3 - Article

VL - 68

SP - 1463

EP - 1468

JO - Talanta

JF - Talanta

SN - 0039-9140

IS - 5

ER -

A clinical assessment of direct electrochemical urate measurements

Abstract

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