A clinical assessment of direct electrochemical urate measurements

JSN Dutt, C Livingstone, MF Cardosi, SJ Wilkins, J Davis

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The response characteristics of various carbon substrates towards the direct oxidative measurement of urate and other key purine biomarkers have been compared. A novel carbon fibre laminate assembly has been proposed as an alternative substrate for the preparation of disposable sensing strips. The fabrication method is generic and readily transferable to a number of sensor applications. Its performance in the determination of urate within biofluids (serum and plasma) has been critically assessed. An inter-Laboratory pilot study demonstrated the bioanalytical efficacy of the approach with the responses validated through comparison with the standard colorimetric (uricase/peroxidase) assay. (c) 2005 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)1463-1468
    JournalTalanta
    Volume68
    Issue number5
    DOIs
    Publication statusPublished - Feb 2006

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