A 2-year randomized controlled trial with low-dose B-vitamin supplementation shows benefits on bone mineral density in adults with lower B12 status

Michelle Clements, Maria Heffernan, Mary Ward, Leane Hoey, Leanne C Doherty, Roberta Hack Mendes, Michelle M Clarke, Catherine F Hughes, Ingrid Love, Shauna Murphy, Eilish McDermott, Jennifer Grehan, Adrian McCann, Liadhan B McAnena, JJ Strain, Lorraine Brennan, Helene McNulty

Research output: Contribution to journalArticlepeer-review

Abstract

Folate, vitamins B12, B6 and riboflavin are required for one-carbon metabolism and may affect bone health, but no previous randomized trial has investigated all four nutrients in this context. We investigated the effect of low-dose B-vitamins for 2 years on bone mineral density (BMD) in adults. This was a dual-centered, 2-year randomized controlled trial (RCT) in adults ≥50 years. Eligible participants not consuming B-vitamin supplements, or fortified foods >4 times weekly, were randomized to receive daily either combined folic acid (200µg), vitamin B12 (10µg), vitamin B6 (10mg) and riboflavin (5mg), or ‘active’ placebo, whereby both the intervention and placebo groups received vitamin D (10µg). BMD was assessed before and after intervention using dual-energy X-ray absorptiometry (DXA) scanning of the total hip, femoral neck and lumbar spine (L1-L4). Of 205 eligible participants randomized, 167 completed the trial in full. B-vitamin intervention resulted in increases in serum folate (P
Original languageEnglish
Number of pages40
JournalJournal of Bone and Mineral Research
Early online date21 Sep 2022
DOIs
Publication statusE-pub ahead of print - 21 Sep 2022

Keywords

  • B-vitamins
  • One-carbon metabolism
  • Bone mineral density
  • Osteoporosis
  • Aging

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