A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness.

Yanbin Dong, Inger S. Stallmann-Jorgensen, Norman K. Pollock, Ryan A. Harris, Daniel Keeton, Ying Huang, Reda Bassali, De-huang Guo, Jeffrey Thomas, Gary L. Pierce, Jennifer White, Michael F. Holick, Haidong Zhu

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    198 Citations (Scopus)

    Abstract

    Context: Vitamin D insufficiency/deficiency is commonly observed in black youth.Objective: The aim was to determine 25-hydroxyvitaminD[25(OH)D] in response to 2000 IU vitaminD supplementation over time; to evaluate the relation between 25(OH)D concentrations and totalbody fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV).Design: We conducted a randomized, blinded, controlled clinical trial.Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 1.4 yr, wererandomly assigned to either the control group (400 IU/d; n 24) or the experimental group (2000IU/d; n 25).Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.010.6, 44.99.4, 51.211.1, and 59.818.2 nmol/liter, respectively, for the control group; and 33.18.7, 55.011.8, 70.922.0, and 85.730.1 nmol/liter, respectively, for the experimental group. The experimental group vs.the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively.Partial correlation analyses indicated that totalbodyfatmassat baselinewassignificantlyandinverselyassociated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoralPWVincreased from baseline (5.380.53 m/sec) to posttest (5.710.75 m/sec) in the control group (P 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 0.73 m/sec) to posttest (5.33 0.79 m/sec) (P 0.031).Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin Dstatus and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
    Original languageEnglish
    Pages (from-to)4584-4591
    JournalThe Journal of Clinical Endocrinology & Metabolism
    Volume95
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2010

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