3D printed biodegradable multifunctional implants for effective breast cancer treatment

Matteo Di Luca, Clare Hoskins, Francesca Corduas, Rachel Onchuru, Adeolu Oluwasanmi, Davide Mariotti, Bice Conti, Dimitrios A Lamprou

Research output: Contribution to journalArticlepeer-review

Abstract

By carefully controlling the dose administered and the drug release rate from drug-eluting implants, safety and efficacy of the therapeutic agent dispensed can be improved. The present work focuses on the promising advantages of 3D Bioprinting process in developing two layers' implantable scaffolds. The two layers have different functions, in order to ensure a more effective and synergistic breast cancer therapy. First layer involves use of polymers such as Poly- ε-Caprolactone (PCL) and Chitosan (CS), and incorporation of 5-Fluorouracil (5-FU). The aim of the first layer is releasing the drug within 4 weeks, obtaining a prolonged and modified release. According to in vitro drug release tests performed, ∼32 % of 5-FU was released after one month, after an initial burst effect of 17.22 %. The sudden release of the drug into the body would quickly reach an effective therapeutic concentration, while the drug sustained release maintains an effective therapeutic concentration range during the administration time. The second layer is made exclusively from PCL as polymeric matrix, into which Gold Nanoparticles (AuNPs) were subsequently loaded, and its main purpose is to be radiation enhancement. The long biodegradation time of PCL would make the non-soluble scaffold an alternative to conventional chemotherapy, optimizing drug release to the specific needs of the patients. [Abstract copyright: Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.]
Original languageEnglish
Article number122363
JournalInternational Journal of Pharmaceutics
Volume629
Early online date3 Nov 2022
DOIs
Publication statusPublished online - 3 Nov 2022

Keywords

  • Bioprinting
  • Biodegradable implants
  • Breast cancer
  • Au Nanoparticles
  • 5-Fluorouracil
  • Additive manufacturing

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