3D electrohydrodynamic printing of highly aligned dual-core graphene composite matrices

Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming Wei Chang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to develop an EHD printing method to fabricate graphene-loaded polycaprolactone (PCL)/polyethylene oxide (PEO) dual-core matrices. Graphene was incorporated in shell PCL components, while gelatin and dopamine hydrochloride (DAH) were encapsulated in two PEO cores to enhance biocompatibility of graphene-loaded matrices. Furthermore, the effect of PEO concentration on dual-core fiber formation was evaluated. The influence of process parameters (applied voltage, inner flow rate, outer flow rate and X-Y-Z collector stage speed) on dual-core fiber morphology was evaluated. Our findings show graphene-loaded structures to possess two inner cores and increasing graphene content yields matrices with smoother surfaces, causing a slight reduction in their contact angle behavior. Furthermore, the addition of graphene to matrices results in reduced elasticity. DAH release from matrices comprising various graphene concentrations showed no significant difference and drug release mechanism was diffusion based. In vitro biological tests indicate resulting graphene-loaded dual-core matrices exhibit good biocompatibility and also improve PC12 cell migration. The findings suggest matrices to have potential applications in nerve restoration and regeneration.

LanguageEnglish
Pages285-297
Number of pages13
JournalCarbon
Volume153
Early online date9 Jul 2019
DOIs
Publication statusPublished - Nov 2019

Fingerprint

Electrohydrodynamics
Graphite
Graphene
Printing
Composite materials
Polyethylene oxides
Polycaprolactone
Biocompatibility
Dopamine
Flow rate
Fibers
Gelatin
Restoration
Contact angle
Elasticity
Electric potential

Keywords

  • Graphene
  • Dual-core
  • Matrices
  • PC12 cells
  • EHD printing

Cite this

Wang, Baolin ; Chen, Xing ; Ahmad, Zeeshan ; Huang, Jie ; Chang, Ming Wei. / 3D electrohydrodynamic printing of highly aligned dual-core graphene composite matrices. In: Carbon. 2019 ; Vol. 153. pp. 285-297.
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3D electrohydrodynamic printing of highly aligned dual-core graphene composite matrices. / Wang, Baolin; Chen, Xing; Ahmad, Zeeshan; Huang, Jie; Chang, Ming Wei.

In: Carbon, Vol. 153, 11.2019, p. 285-297.

Research output: Contribution to journalArticle

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