Personal profile
Biography
Senior Lecturer in Personalised Medicine within the School of Medicine.
Research interests are in immunological and inflammatory disease with a key interest in the NLRP3 Inflammasome, therapeutic antibody development and biomarker translation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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NLRP3 Inflammasome inhibition by the novel bispecific antibody InflamAb attenuates atherosclerosis in apolipoprotein E-deficient mice
Delfos, L., Depuydt, M. A. C., Chemaly, M., Coyle, S., Schaftenaar, F. H., van Santbrink, P. J., Lindenbergh, P. P., Bernabé Kleijn, M. N. A., Costello, C., Power, C. A., Coll, R., Peace, A., Gregory-Ksander, M., Foks, A. C., Kuiper, J., McGilligan, V. E. & Bot, I., 30 Jun 2025, In: JACC Basic to Translational Science. 10, 6, p. 826-840 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)70 Downloads (Pure) -
InflaMab: A novel NLRP3 Inflammasome inhibitor provides neuroprotection in a mouse model of glaucoma
McGilligan, V. E., El Chemaly, M., Krishnan, A., Bjourson, A., Peace, A. & Gregory-Ksander, M., 1 Jun 2020, InflaMab: A novel NLRP3 Inflammasome inhibitor provides neuroprotection in a mouse model of glaucoma. 7 ed. Association for Research in Vision and Ophthalmology, Vol. 61. p. 2365Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Exploring the involvement of NLRP3 and Il-1β in Osteoarthritis of the Hand: Results from a Pilot Study
Fioravanti, A., Tenti, S., McAllister, M., El Chemaly, M., Eakin, A., McLaughlin, J., Bjourson, A., Frati, E., McGilligan, V. E., Gibson, D. & Cheleschi, S., 10 Mar 2019, In: Mediators of Inflammation. 2019, 13 p., 2363460 .Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Link opens in a new tab Citations (Scopus)114 Downloads (Pure) -
Targeting the NLRP3 Inflammasome in Glaucoma
Coyle, S., Khan, M. N., Chemaly, M., Callaghan, B., Doyle, C., Willoughby, C. E., Atkinson, S. D., Gregory-Ksander, M. & McGilligan, V., 19 Aug 2021, (Published online) In: Biomolecules. 11, 8, p. 1-14 14 p., e1239.Research output: Contribution to journal › Review article › peer-review
Open AccessFile53 Link opens in a new tab Citations (Scopus)150 Downloads (Pure) -
The nlrp3 inflammasome and other related receptors as potential biomarkers in coronary artery disease (cad) and major adverse cardiac events (mace)
McGilligan, V. E., 5 Oct 2017, The nlrp3 inflammasome and other related receptors as potential biomarkers in coronary artery disease (cad) and major adverse cardiac events (mace). 6 ed. BMJ Specialist Journals, Vol. 103.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Prizes
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Collaborative Award for Teaching Excellence (CATE)
McClean, P. (Recipient), Kelly, C. (Recipient), Atkinson, S. (Recipient), Bjourson, T. (Recipient), Duddy, W. (Recipient), Duguez, S. M. (Recipient), Gibson, D. (Recipient), Matchett, K. (Recipient), McDowell, A. (Recipient), Mc Gilligan, V. (Recipient), Murray, E. (Recipient), Shukla, P. (Recipient), Rai, T. S. (Recipient), Watterson, S. (Recipient) & Zhang, S.-D. (Recipient), 3 Oct 2024
Prize: Honorary award
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Distinguished Collaborative Education Excellence Fellowship
McClean, P. (Recipient), Kelly, C. (Recipient), Gibson, D. (Recipient), Mc Gilligan, V. (Recipient), Murray, E. (Recipient), Atkinson, S. (Recipient), Watterson, S. (Recipient), McDowell, A. (Recipient), Duguez, S. M. (Recipient), Duddy, W. (Recipient), Shukla, P. (Recipient), Matchett, K. (Recipient), Rai, T. S. (Recipient) & Zhang, S.-D. (Recipient), 7 Jun 2023
Prize: Honorary award
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Activities
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Targeting the NLRP3 inflammasome in Glaucoma
McGilligan, V. (Speaker)
22 Oct 2024Activity: Talk or presentation › Invited talk
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Targeting the NLRP3 Inflammasome in Glaucoma
Mc Gilligan, V. (Speaker) & Coyle, S. (Speaker)
24 May 2022 → 27 May 2022Activity: Talk or presentation › Poster presentation
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Can blood biomarkers augment ECG interpretation?
Mc Gilligan, V. (Speaker)
1 May 2019Activity: Talk or presentation › Invited talk
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Extensive Plasma Biomarker Analysis in Patients with Acute Myocardial Infarction
Mc Gilligan, V. (Speaker)
12 Sept 2018Activity: Talk or presentation › Oral presentation
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C-TRIC TMED4 Conference
Moore, T. (Participant), Atkinson, S. (Participant), McGilligan, V. E. (Participant), Liao, H. (Participant), Irvine, I. (Participant), Porter, L. F. (Participant), Corden, L. D. (Participant), MacEwen, C. J. (Participant), Weed, K. H. (Participant), Moore, J. E. (Participant), Szeverenyi, I. (Participant), Smith, F. (Participant) & McLean, W. H. I. (Participant)
10 May 2012Activity: Participating in or organising an event › Participating in a conference, workshop, ...
Profiles
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InflamAb for Hidradenitis Suppraventitia
McGilligan, V. (PI) & McDowell, A. (CoI)
12/09/25 → 12/03/27
Project: Research
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iMPROVE
Gibson, D. (PI), Courtenay, A. (CoI), Kelly, C. (CoI), Murray, E. (CoI), Condell, J. (CoI), Dubras, L. (CoI), McClean, P. (CoI), Shukla, P. (CoI), Zhang, S.-D. (CoI) & McGilligan, V. (CoI)
1/03/25 → 28/02/29
Project: Research
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A novel bispecific antibody therapy targeting the NLRP3 inflammasome for glaucoma
McGilligan, V. (PI) & Willoughby, C. (CoI)
1/01/25 → 1/01/27
Project: Research
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PEACETIME
Miras, A. (PI), Logue, C. (CoI), Kelly, C. (CoI), Gibson, D. (CoI), Murray, E. (CoI), Condell, J. (CoI), Ward, M. (CoI), Price, R. (CoI), McGilligan, V. (CoI) & Coates, V. (CoI)
1/01/25 → 31/12/28
Project: Research
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Investigating the role of the NLRP3 inflammasome and metalloproteinases in neuroinflammatory disease.
McGilligan, V. (PI), Gibson, D. (CoI), Murray, E. (CoI) & McClean, P. (CoI)
1/09/24 → 31/08/27
Project: Research