• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 3840 Citations
  • 36 h-Index
19992020

Research output per year

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Research Output

  • 3840 Citations
  • 36 h-Index
  • 189 Article
2020

Dapagliflozin and Liraglutide therapies rapidly enhanced bone material properties and matrix biomechanics at bone formation site in a type 2 diabetic mouse model

Mieczkowska, A., Millar, P., Chappard., D., Gault, V. A. & Mabilleau, G., 26 Jun 2020, In : Calcified Tissue International. xx, p. xx

Research output: Contribution to journalArticle

Ψ-xenin-6 enhances sitagliptin effectiveness, but does not improve glucose tolerance

Craig, S., Gault, V. A., Hamscher, G. & Irwin, N., 4 Mar 2020, (Accepted/In press) In : Journal of Endrocrinology. 245, 2, p. 219-230

Research output: Contribution to journalArticle

2019
1 Citation (Scopus)
Open Access
File
1 Citation (Scopus)
Open Access
File
5 Citations (Scopus)
3 Downloads (Pure)
Open Access
File
2 Citations (Scopus)

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, D., Hull, C., Plucińska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V. A., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety

Davies, M., Kalsi, G., Armour, C., Jones, I., McIntosh, A., Smith, D., Walters, J., Bradley, J., Kingston, N., Ashford, S., Beange, I., Brailean, A., Cleare, A., Coleman, J., Curtis, C., Curzons, S., Davis, K., Dowey, L., Gault, V. A., Goldsmith, K. & 32 others, Bennett, M., Hirose, Y., Hotopf, M., Hübel, C., Kanz, C., Leng, J., Lyall, D., Mason, B., McAtarsney-Kovacs, M., Monssen, D., Moulton, A., Ovington, N., Palaiologou, E., Pariante, C., Parikh, S., Peel, A., Price, RK., Rimes, K., Rogers, H., Sambrook, J., Skelton, M., Spaul, A., Suarez, E., Sykes, B., Thomas, K., Young, A., Vassos, E., Veale, D., White, K., Wingrove, J., Eley, T. & Breen, G., 1 Dec 2019, In : Behaviour Research and Therapy. 123, 103503, 28 p., 103503.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
18 Downloads (Pure)
2018
Open Access
15 Citations (Scopus)

Beneficial metabolic effects of dietary epigallocatechin gallate alone and in combination with exendin-4 in high fat diabetic mice

Pathak, NM., Millar, PJB., Pathak, V., Flatt, P. & Gault, V. A., 15 Jan 2018, In : Molecular and Cellular Endocrinology. 460, p. 200-208

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Characterisation and antidiabetic utility of a novel hybrid peptide, exendin-4/gastrin/xenin-8-Gln

Hasib, A., NG, T., Khan, D., Gault, V. A., Flatt, PR. & Irwin, N., 17 Jul 2018, In : European Journal of Pharmacology. 834, p. 126-135

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
5 Downloads (Pure)

Emerging therapeutic potential for xenin and related peptides in obesity and diabetes

Craig, SL., Gault, V. A. & Irwin, N., 6 Apr 2018, In : Diabetes Metabolism Research and Reviews. e3006, p. e3006 5 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

Pathak, NM., Pathak, V., Gault, V. A., McClean, S., Irwin, N. & Flatt, PR., 19 Jul 2018, In : Biochemical Pharmacology. 155, p. 264-274 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
1 Downloads (Pure)
Open Access
17 Citations (Scopus)
2017

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice

Hasib, A., Ng, M. T., Gault, V. A., Khan, D., Parthsarathy, V., Flatt, P. & Irwin, N., 31 Mar 2017, In : Diabetologia. 60, 3, p. 541-552 12 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
5 Downloads (Pure)
Open Access
9 Citations (Scopus)
Open Access
14 Citations (Scopus)

Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice

Millar, P., Pathak, N., Parthsarathy, V., Bjourson, AJ., O'Kane, M., Pathak, V., Moffett, C., Flatt, P. & Gault, V. A., 23 Jun 2017, (Accepted/In press) In : Journal of Endrocrinology. 234, 3, p. 255-267

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes.

Gault, V. A., 16 Oct 2017, In : Diabetic medicine. N/A

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2016
Open Access
File
10 Downloads (Pure)

A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties

Parthsarathy, V., Irwin, N., Hasib, A., Martin, CM., McClean, S., Bhat, VK., Ng, M. T., Flatt, P. & Gault, V. A., 30 Apr 2016, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1860, 4, p. 757-764 8 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
20 Downloads (Pure)

Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice

Millar, PJ., Pathak, V., Moffett, C., Pathak, NM., Bjourson, AJ., OKane, MJ., Flatt, P. & Gault, V., 15 Jan 2016, In : Molecular and Cellular Endocrinology. 420, p. 37-45 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin

Martin, MA., Parthsarathy, V., Hasib, A., NG, T., McClean, S., Flatt, P., Gault, V. A. & Irwin, N., 31 Mar 2016, In : PLoS ONE. 11, 3, p. 1-14 14 p., e0152818.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
1 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
34 Downloads (Pure)
2015
Open Access
27 Citations (Scopus)
Open Access
13 Citations (Scopus)
Open Access
4 Citations (Scopus)
19 Citations (Scopus)
Open Access
75 Citations (Scopus)
Open Access
16 Citations (Scopus)
Open Access
8 Citations (Scopus)

Xenin-25[Lys(13)PAL]: a novel long-acting acylated analogue of xenin-25 with promising antidiabetic potential

Gault, V., Martin, CM., Flatt, P., V, P. & Irwin, N., 1 Jun 2015, In : Acta Diabetologica. 52, 3, p. 461-471

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)
2014
16 Citations (Scopus)

Characterisation of the biological activity of xenin-25 degradation fragment peptides

Martin, CA., Parthsarathy, V., Pathak, V., Gault, V., Flatt, P. & Irwin, N., 22 Apr 2014, In : Journal of Endrocrinology. 221, 2, p. 193-200

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
Open Access
15 Citations (Scopus)
Open Access
38 Citations (Scopus)

Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice

Lennox, R., Flatt, P. & Gault, V., 1 Nov 2014, In : Peptides. 61, p. 38-47

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
2013

(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

Lennox, R., Porter, DW., Flatt, P. & Gault, V., 1 Mar 2013, In : ChemMedChem. 8, 4, p. 595-602

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice.

Bhat, VK., Kerr, BD., Vasu, S., Flatt, P. & Gault, V., 17 Mar 2013, In : Diabetologia. 56, 6, p. 1417-1424

Research output: Contribution to journalArticle

Open Access
42 Citations (Scopus)

A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores

Martin, CM., Irwin, N., Flatt, P. & Gault, V., 18 Jun 2013, In : BIOCHIMICA ET BIOPHYSICA ACTA. 1830, 6, p. 3407-3413

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)
Open Access
48 Citations (Scopus)
Open Access
75 Citations (Scopus)

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

Porter, DW., Flatt, P., Holscher, C. & Gault, V., 5 Jun 2013, In : International Journal of Obesity. 37, 5, p. 678-684

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Unraveling the mechanisms underlying olanzapine-induced insulin resistance

Irwin, N. & Gault, V., 1 Sep 2013, In : Diabetes. 62, 9, p. 3022-3023

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2012

Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice

Porter, D., Faivre, E., Flatt, P., Holscher, C. & Gault, V., May 2012, In : Peptides. 35, 1, p. 1-8

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)