Personal profile
Biography
Dr Steven Watterson is a Computational Biologist at the Northern Ireland Centre for Stratified Medicine with research interests in cholesterol metabolism and cardiovascular disease. Steven employs Systems Biology approaches to biomedical science and is interested in developing new tools and resources for use in biomedical science.
Research Interests. Steven’s research focuses on the networks of interactions that exist between genes, proteins and small molecules that determine biological function. In particular, Steven is interested in how the dynamics of these networks alter in disease, how they vary within and between populations and how they can be reprogrammed therapeutically.
Teaching Interests. Steven is a fellow of the Higher Education Academy. He current serves as lecturer on the BSc and MSc degrees in Stratified Medicine. He is a module coordinator for the BSc module BIO123 – Mathematical and Computational Methods 1 and the MSc module BIO826 – Mathematical and Computational Methods.
Background. Steven has a first class MPhys Hons in Physics from the University of Edinburgh, a PhD in mathematics from Trinity College, Dublin and has studied non-equilibrium systems with Dr Chris Jarzynski at Los Alamos Laboratories. He spent six years as a research fellow at the University of Edinburgh investigating the role of cholesterol metabolism in innate immunity in the lab of Prof Peter Ghazal at the Division of Infection and Pathway Medicine. Here, he was part of the team to first uncover how cholesterol metabolism is regulated in response to cytomegalovirus infection. Whilst at the University of Edinburgh, Steven also held joint appointments with the Centre for Synthetic and Systems Biology.
Membership. Steven is a member of the Life and Medical Sciences Advisory Committee of the Royal Irish Academy and currently serves on the editorial board of Frontiers in Synthetic Biology. He is also a member of the European Atherosclerosis Society and the Genetics Society.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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The Systems Biology Graphical Notation
Novere, N. L., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., Demir, E., Wegner, K., Aladjem, M., Wimalaratne, S., Bergman, F., Gauges, R., Ghazal, P., Kawaji, H., Li, L., Matsuoka, Y., Villeger, A., Boyd, S., Calzone, L. & Courtot, M. & 19 others, , 7 Aug 2009, In: Nature Biotechnology. 27, p. 735-741Research output: Contribution to journal › Article › peer-review
Open Access723 Link opens in a new tab Citations (Scopus) -
The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
Blanc, M., Hsieh, W. Y., Robertson, K. A., Kai, K. A., Forster, T., Shui, G., Lacaze, P., Watterson, S., Griffiths, S. J., Spann, N. J., Meljon, A., Talbot, S., Krishnan, K., Covey, D. F., Wenk, M. R., Craigon, M., Ruzsics, Z., Haas, J., Angulo, A. & Griffiths, W. J. & 3 others, , 2012, In: Immunity. 38, 1, p. 106-118Research output: Contribution to journal › Article › peer-review
Open Access354 Link opens in a new tab Citations (Scopus) -
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
Blanc, M., Hsieh, W., Robertson, K. A., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodriguez-Martin, S., Phelan, P., Forster, T., Strobl, B., Muller, M., Riemersma, R., Osborne, T., Wenk, M. R., Angulo, A. & Ghazal, P., 8 Mar 2011, In: PLoS Biology. 9, 3, p. e1000598Research output: Contribution to journal › Article › peer-review
Open Access247 Link opens in a new tab Citations (Scopus) -
The genetics and screening of familial hypercholesterolaemia
Watterson, S. & McGilligan, V., 16 Apr 2016, In: Journal of Biomedical Science. 23, 39Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Link opens in a new tab Citations (Scopus)36 Downloads (Pure) -
Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms
Mazein, A., Ostaszewski, M., Kuperstein, I., Watterson, S., Novere, N. L., Lefaudeux, D., De Meulder , B., Pellet , J., Balaur, I., Saqi, M., Manuela Nogueira , M., Q. HeFeng , F., Parton, A., Lemonnier , N., Gawron, P., Gebel, S., Hainaut , P., Ollert, M., Dogrusoz , U. & Barillot , E. & 4 others, , 2 Jun 2018, (Published online) In: npj Systems Biology and Applications. 4, 10 p., 21.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Link opens in a new tab Citations (Scopus)89 Downloads (Pure)
Datasets
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Multimorbidity in the UK Biobank and its change over time
Watterson, S. (Creator), Shukla, P. (Contributor) & Mc Clean, P. (Contributor), Ulster University, 12 Nov 2021
DOI: 10.21251/5dc06676-a5e9-4312-81f0-b3e1b0e00fe3
Dataset
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Matlab Script for fitting sigmoidal curves to infection inhibition data
Ghazal, P. (Creator) & Watterson, S. (Creator), figshare, 12 Nov 2021
DOI: 10.6084/m9.figshare.97311.v1, https://orcid.org/0000-0002-2750-6410
Dataset
Prizes
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Collaborative Award for Teaching Excellence (CATE)
McClean, P. (Recipient), Kelly, C. (Recipient), Atkinson, S. (Recipient), Bjourson, T. (Recipient), Duddy, W. (Recipient), Duguez, S. M. (Recipient), Gibson, D. (Recipient), Matchett, K. (Recipient), McDowell, A. (Recipient), Mc Gilligan, V. (Recipient), Murray, E. (Recipient), Shukla, P. (Recipient), Rai, T. S. (Recipient), Watterson, S. (Recipient) & Zhang, S.-D. (Recipient), 3 Oct 2024
Prize: Honorary award
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Distinguished Collaborative Education Excellence Fellowship
McClean, P. (Recipient), Kelly, C. (Recipient), Gibson, D. (Recipient), Mc Gilligan, V. (Recipient), Murray, E. (Recipient), Atkinson, S. (Recipient), Watterson, S. (Recipient), McDowell, A. (Recipient), Duguez, S. M. (Recipient), Duddy, W. (Recipient), Shukla, P. (Recipient), Matchett, K. (Recipient), Rai, T. S. (Recipient) & Zhang, S.-D. (Recipient), 7 Jun 2023
Prize: Honorary award
Activities
- 1 Consultancy
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Innovation Voucher (IV130297589): Altomics Datamation Limited
Bond, R. (Consultant), Watterson, S. (Consultant) & Mulvenna, M. (Consultant)
6 Mar 2023Activity: Consultancy
Profiles
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Advancing NephroNet - A Senescence Based Diagnostic Platform for CKD
Rai, T. S. (PI) & Watterson, S. (CoI)
1/10/25 → 30/11/26
Project: Research
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Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy
Watterson, S. (PI), Kelly, C. (CoI), McClean, P. (CoI), Zhang, S.-D. (CoI), Rai, T. S. (CoI) & McGilligan, V. (CoI)
Horizon Europe - UKRI Guarantee via JeS
1/01/23 → 31/12/26
Project: Research
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Network for implementing multiomics approaches in atherosclerotic cardiovascular disease prevention and research
Watterson, S. (PI), Rai, T. S. (CoI) & McGilligan, V. (CoI)
EU COST (European Cooperation in Science and Technology) ACTION
1/09/22 → 31/08/26
Project: Research
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Personalised Medicine Centre Multi-Omics Lab (PMC-MOL) - Wolfson Equipment Bid
Kelly, C. (PI), Gibson, D. (CoI), Murray, E. (CoI), Matchett, K. (CoI), McClean, P. (CoI), Shukla, P. (CoI), Zhang, S.-D. (CoI), Duguez, S. M. (CoI), Watterson, S. (CoI), Rai, T. S. (CoI), McGilligan, V. (CoI) & Duddy, W. (CoI)
1/06/25 → 31/12/25
Project: Research
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A novel inhibitor of the NLRP3 inflammasome
Bjourson, T. (CoI), Watterson, S. (CoI), Atkinson, S. (CoI) & McGilligan, V. (PI)
1/03/22 → 30/06/24
Project: Research