• Northlands Road, Magee Campus

    BT48 7JL Londonderry

    United Kingdom

  • 1414 Citations
  • 22 h-Index
19942019
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Research Output 1994 2019

  • 1414 Citations
  • 22 h-Index
  • 85 Article
  • 2 Conference contribution
  • 1 Chapter
2019

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage

Bolderson, E., Burgess, J. T., Li, J., Gandhi, N. S., Boucher, D., Croft, L. V., Beard, S., Plowman, J. J., Suraweera, A., Adams, M. N., Naqi, A., Zhang, S. D., Sinclair, D. A., O’Byrne, K. J. & Richard, D. J., 3 Dec 2019, In : Nature Communications. 10, 1, 5501.

Research output: Contribution to journalArticle

Open Access
File
ribose
adenosine diphosphate
Poly(ADP-ribose) Polymerases
DNA Damage
Repair
2018
26 Citations (Scopus)

A review of connectivity map and computational approaches in pharmacogenomics

Musa, A., Ghoraie, L. S., Zhang, S-D., Glazko, G., Yli-Harja, O., Dehmer, M., Haibe-Kains, B. & Emmert-Streib, F., 1 May 2018, In : Briefings in Bioinformatics. 19, 3, p. 506-523 18 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Libraries
Systems Biology
Drug Design
Databases
7 Citations (Scopus)

DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer

Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y., Yuen, HF., Zhang, S-D., Zhu, Y., Lin, Y. & Kwok, H. F., 22 Aug 2018, In : Cancers. 10, 9, 19 p., 282.

Research output: Contribution to journalArticle

Open Access
File
Licensure
DNA Replication
Biomarkers
Breast Neoplasms
Neoplasms
6 Citations (Scopus)

In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer

Wei, R., Wong, J. P. C., Lyu, P., Xi, X., Tong, O. L. H., Zhang, S-D., Yuen, HF., Shirasawa, S. & Kwok, H. F., 30 May 2018, In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

Open Access
File
Osteopontin
Colorectal Neoplasms
Metalloproteases
Cadherins
Genes
4 Citations (Scopus)

Post-diagnostic calcium channel blocker use and breast cancer mortality: a population-based cohort study

Busby, J., Mills, K., Zhang, S-D., Liberante, F. G. & Cardwell, C., 15 May 2018, In : Epidemiology. 29, 3, p. 407–413

Research output: Contribution to journalArticle

4 Citations (Scopus)

Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study

Busby, J., Mills, K., Zhang, S-D., Liberante, F. G. & Cardwell, C. R., 19 Jan 2018, In : Breast Cancer Research. 20, 1

Research output: Contribution to journalArticle

Open Access
2017
4 Citations (Scopus)

A combined connectivity mapping and pharmacoepidemiology approach to identify existing medications with breast cancer causing or preventing properties

Busby, J., Murray, L., Mills, K., Zhang, S-D., Liberante, F. & Cardwell, C. R., 4 Dec 2017, In : Pharmacoepidemiology and Drug Safety. 27, 1, p. 78-86

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

A generic Transcriptomics Reporting Framework (TRF) for ‘omics data processing and analysis

Gant, T. W., Sauer, U. G., Zhang, S-D., Chorley, B. N., Hackermüller, J., Perdichizzi, S., Tollefsen, K. E., van Ravenzwaay, B., Yauk, C., Tong, W. & Poole, A., 4 Nov 2017, In : Regulatory Toxicology and Pharmacology. 91, p. S36-S45

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

An integrated meta-analysis approach to identifying medications with potential to alter breast cancer risk through connectivity mapping

Thillaiyampalam, G., Liberante, F., Murray, L., Cardwell, C., Mills, K. & Zhang, S-D., 21 Dec 2017, In : BMC Bioinformatics. 18, 1

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)

CD133 in brain tumor: the prognostic factor

Li, B., McCrudden, C. M., Fung Yuen, H., Xi, X., Lyu, P., Wah Chan, K., Zhang, S-D. & Fai Kwok, H., 14 Feb 2017, In : Oncotarget. 8, 7, p. 11144-11159

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer

Wong, J. P. C., Wei, R., Lyu, P., Tong, O. L. H., Zhang, S-D., Wen, Q., Yuen, H. F., El-Tanani, M. & Kwok, H. F., 1 Nov 2017, In : International Journal of Biological Sciences. 13, 11, p. 1373-1386

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

DAPK1 as an independent prognostic marker in liver cancer

Li, L., Guo, L., Wang, Q., Liu, X., Zeng, Y., Wen, Q., Zhang, S., Kwok, H. F., Lin, Y. & Liu, J., 1 Jan 2017, In : PeerJ. 2017, 7, 1 p., e3568.

Research output: Contribution to journalArticle

Death-Associated Protein Kinases
liver neoplasms
Liver Neoplasms
protein kinases
Liver
6 Citations (Scopus)

Expression of CDCA3 Is a Prognostic Biomarker and Potential Therapeutic Target in Non–Small Cell Lung Cancer

Adams, M. N., Burgess, J. T., He, Y., Gately, K., Snell, C., Zhang, S-D., Hooper, J. D., Richard, D. J. & O’Byrne, K. J., 15 Jul 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1071-1084

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Expression of minichromosome maintenance genes in renal cell carcinoma

Zhong, H., Chen, B., Neves, H., Xing, J., Ye, Y., Lin, Y., Zhuang, G., Zhang, S-D., Huang, J. & Kwok, H. F., 15 Nov 2017, In : Cancer Management and Research. Volume, p. 637-647

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

Wen, Q., Dunne, P. D., O’Reilly, P. G., Li, G., Bjourson, T., McArt, D. G., Hamilton, P. W. & Zhang*, S-D., 10 Jan 2017, In : Oncotarget. 8, 2, p. 3206-3225 19 p.

Research output: Contribution to journalArticle

Open Access
File
Angiotensin Receptor Antagonists
Neoplasm Genes
Colorectal Neoplasms
Antihypertensive Agents
Pharmaceutical Preparations
16 Citations (Scopus)

The prognostic significance of Cdc6 and Cdt1 in breast cancer

Mahadevappa, R., Neves, H., Yuen, S. M., Bai, Y., McCrudden, C. M., Yuen, H. F., Wen, Q., Zhang, S-D. & Kwok, H. F., 20 Apr 2017, In : Scientific Reports. 7, 1, 985.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)

The prognostic significance of DAPK1 in bladder cancer

Chen, P-C., Xie, J-Y., Zhang, J-L., Gao, Z-S., Neves, H., Zhang, S-D., Wen, Q., Chen, W-D., Kwok, H. F. & Lin, Y., 7 Apr 2017, In : PLoS ONE. 12, 4, p. e0175290

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)

β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

Ling, Y-M., Chen, J-Y., Guo, L., Wang, C-Y., Tan, W-T., Wen, Q., Zhang, S-D., Deng, G-H., Lin, Y. & Kwok, H. F., 17 Oct 2017, In : Scientific Reports. 7, 1

Research output: Contribution to journalArticle

Open Access
File
2016
6 Citations (Scopus)

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response

Burgess, J. T., Bolderson, E., Adams, M. N., Baird, A-M., Zhang, S-D., Gately, K. A., Umezawa, K., O’Byrne, K. J. & Richard, D. J., 10 Nov 2016, In : Cell Death and Disease. 7, 11, p. e2469

Research output: Contribution to journalArticle

Open Access
File
Caspase 3
Apoptosis
Neoplasms
src Homology Domains
Proteolysis
5 Citations (Scopus)

A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

Wen, Q., Kim, C-S., Hamilton, P. W. & Zhang, S-D., 11 May 2016, In : BMC Bioinformatics. 17, 1

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

Barbone, D., Van Dam, L., Follo, C., Jithesh, P. V., Zhang, S-D., Richards, W. G., Bueno, R., Fennell, D. A. & Broaddus, V. C., 16 Mar 2016, In : PLoS ONE. 11, 3, p. e0150044

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)

Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer

Zhang, S-D., Mccrudden, C., Yuen, HF., Leung, K., Hong, WJ. & Kwok, H., Feb 2016, In : Oncology Letters. 11

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)

Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis

Malcomson, B., Wilson, H., Veglia, E., Thillaiyampalam, G., Barsden, R., Donegan, S., El Banna, A., Elborn, J. S., Ennis, M., Kelly, C., Zhang, S-D. & Schock, B. C., 28 Jun 2016, In : Proceedings of the National Academy of Sciences. 113, 26, p. E3725-E3734 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cystic Fibrosis
Anti-Inflammatory Agents
Pharmaceutical Preparations
Epithelial Cells
Fibrosis

PRL3-zumab, a first-in-class humanized antibody for cancer therapy

Thura, M., Al-Aidaroos, A. Q. O., Yong, W. P., Kono, K., Gupta, A., Lin, Y. B., Mimura, K., Thiery, J. P., Goh, B. C., Tan, P., Soo, R., Hong, C. W., Wang, L., Lin, S. J., Chen, E., Rha, S. Y., Chung, H. C., Li, J., Nandi, S., Yuen, H. F. & 4 othersZhang, S-D., Guan, Y. K., So, J. & Zeng, Q., 16 Jun 2016, In : JCI Insight. 1, 9

Research output: Contribution to journalArticle

Open Access
File
Antibodies, Monoclonal, Humanized
Neoplasms
Stomach Neoplasms
Therapeutics
Stomach
14 Citations (Scopus)

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

O’Reilly, P. G., Wen, Q., Bankhead, P., Dunne, P. D., McArt, D. G., McPherson, S., Hamilton, P. W., Mills, K. I. & Zhang, S-D., 4 May 2016, In : BMC Bioinformatics. 17, 198

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)

SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer

Burgess, J. T., Bolderson, E., Saunus, J. M., Zhang, S-D., Reid, L. E., McNicol, A. M., Lakhani, S. R., Cuff, K., Richard, K., Richard, D. J. & O’Byrne, K. J., 14 Sep 2016, In : Oncotarget. 7, 45, p. 72807-72818

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Apoptosis
chloropyramine
Cell Line
Neoplasms
2015
1 Citation (Scopus)

Computational cancer biology: education is a natural key to many locks

Emmert-Streib, F., Zhang, S-D. & Hamilton, P., 15 Jan 2015, In : BMC Cancer. 15, 1, p. 7

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

Wen, Q., O'Reilly, P., Dunne, P. D., Lawler, M., Van Schaeybroeck, S., Salto-Tellez, M., Hamilton, P. & Zhang, S-D., 2015, In : BMC Systems Biology. 9, Suppl, p. S4

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)

Cystic Fibrosis from Laboratory to Bedside: The Role of A20 in NF-κB-Mediated Inflammation

Bannon, A., Zhang, S-D., Schock, B. C. & Ennis, M., 25 Apr 2015, In : Medical Principles and Practice. 24, 4, p. 301-310

Research output: Contribution to journalArticle

Open Access
File

Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia

Liberante, F. G., Pouryahya, T., McMullin, M-F., Zhang*, S-D. & Mills*, K. I., 28 Dec 2015, In : Oncotarget. 7, 6

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)

PRL-3 activates mTORC1 in Cancer Progression

Ye, Z., Al-aidaroos, A. Q. O., Park, J. E., Yuen, H. F., Zhang, S-D., Gupta, A., Lin, Y., Shen, H-M. & Zeng, Q., 24 Nov 2015, In : Scientific Reports. 5, p. 17046

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Prognostic significance of combining VEGFA, FLT1 and KDR mRNA expression in lung cancer

Zhang, S-D., Mccrudden, C. & Kwok, H., 24 Jun 2015, In : Oncology Letters. 10

Research output: Contribution to journalArticle

Open Access
39 Citations (Scopus)

Prognostic significance of minichromosome maintenance proteins in breast cancer.

Kwok*, H. F., Zhang*, S-D., McCrudden, C. M., Yuen, H-F., Ting, K-P., Wen, Q., Khoo, U-S. & Chan, K. Y-K., 1 Jan 2015, In : American Journal of Cancer Research. 5, 1, p. 52-71

Research output: Contribution to journalArticle

Open Access
File
Minichromosome Maintenance Proteins
Breast Neoplasms
Maintenance
Confidence Intervals
Survival
9 Citations (Scopus)

The Prognostic Significance of Combining VEGFA, FLT1 and KDR mRNA Expressions in Brain Tumors

Zhang, S-D., Leung, K. L., McCrudden, C. M. & Kwok, H. F., 2015, In : Journal of Cancer. 6, 9, p. 812-818

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)

The prognostic significance of PD-L1 in bladder cancer

Huang*, Y., Zhang*, S-D., McCrudden, C., Chan, K-W., Lin, Y. & Kwok, H-F., 27 Apr 2015, In : Oncology Reports. 33

Research output: Contribution to journalArticle

Open Access
File

The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer

Zhao, D., Guo, L., Neves, H., Yuen, H-F., Zhang, S-D., McCrudden, C. M., Wen, Q., Zhang, J., Zeng, Q., Kwok, H. F. & Lin, Y., 13 Jul 2015, In : OncoTargets and Therapy. 8, p. 1707

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)

The significance of combining VEGFA, FLT1, and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab

Zhang, S-D., McCrudden, C. M., Chen, M., Lin, Y. & Kwok, H. F., 2015, In : OncoTargets and Therapy. 8, p. 835

Research output: Contribution to journalArticle

Open Access
File
2014
28 Citations (Scopus)

A role of autophagy in PTP4A3-driven cancer progression

Huang, Y-H., Al-aidaroos, A. Q. O., Yuen, H-F., Zhang, S-D., Shen, H-M., Rozycka, E., McCrudden, C. M., Tergaonkar, V., Gupta, A., Lin, Y. B., Thiery, J. P., Murray, J. T. & Zeng, Q., 2014, In : Autophagy. 10, 10, p. 1787-1800

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Dry computational approaches for wet medical problems

Emmert-Streib, F., Zhang, S-D. & Hamilton, P., 2014, In : Journal of Translational Medicine. 12, 1, p. 26

Research output: Contribution to journalArticle

Open Access
File

Integrative analysis of chemo-transcriptomic profiles for drug-feature specific gene expression signatures

Kim, C. S., Wen, Q. & Zhang, S-D., 2 Nov 2014, Unknown Host Publication. p. 113-118 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
13 Citations (Scopus)

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation

Paquet, N., Box, J. K., Ashton, N. W., Suraweera, A., Croft, L. V., Urquhart, A. J., Bolderson, E., Zhang, S-D., O’Byrne, K. J. & Richard, D. J., 12 Dec 2014, In : BMC Molecular Biology. 15, 1

Research output: Contribution to journalArticle

Open Access
File

Report from the 2nd Summer School in Computational Biology organized by the Queen's University of Belfast

Emmert-Streib, F., Zhang, S-D. & Hamilton, P., 14 Feb 2014, In : Genomics Data. 2, p. 37-39

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

RMA with quantile normalization mixes biological signals between different sample groups in microarray data analysis

Kim, C. S., Hwang, S. & Zhang, S-D., 2 Nov 2014, Unknown Host Publication. p. 139-143 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
2013
13 Citations (Scopus)

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

McArt, D. G., Dunne, P. D., Blayney, J. K., Salto-Tellez, M., Van Schaeybroeck, S., Hamilton, P. W. & Zhang, S-D., 2013, In : PLoS ONE. 8, 6, p. e66902

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)

cudaMap: a GPU accelerated program for gene expression connectivity mapping

McArt, D. G., Bankhead, P., Dunne, P. D., Salto-Tellez, M., Hamilton, P. & Zhang, S-D., 2013, In : BMC Bioinformatics. 14, 1, p. 305

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)

Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene-Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia

Ramsey, J. M., Kettyle, L. M. J., Sharpe, D. J., Mulgrew, N. M., Dickson, G. J., Bijl, J. J., Austin, P., Mayotte, N., Cellot, S., Lappin, T. R. J., Zhang, S-D., Mills, K. I., Krosl, J., Sauvageau, G. & Thompson, A., 2013, In : Stem Cells. 31, 7, p. 1434-1445

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)

Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells

Al-aidaroos, A. Q. O., Yuen, H. F., Guo, K., Zhang, S-D., Chung, T-H., Chng, W. J. & Zeng, Q., 2013, In : Journal of Clinical Investigation. 123, 8, p. 3459-3471

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia

Park, J. E., Yuen, H. F., Zhou, J. B., Al-aidaroos, A. Q. O., Guo, K., Valk, P. J., Zhang, S-D., Chng, W. J., Hong, C. W., Mills, K. & Zeng, Q., 2013, In : EMBO Molecular Medicine. 5, 9, p. 1351-1366

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)

RanGTPase: A Candidate for Myc-Mediated Cancer Progression

Yuen, H-F., Gunasekharan, V-K., Chan, K-K., Zhang, S-D., Platt-Higgins, A., Gately, K., O'Byrne, K., Fennell, D. A., Johnston, P. G., Rudland, P. S. & El-Tanani, M., 2013, In : JNCI: Journal of the National Cancer Institute. 105, 7, p. 475-488

Research output: Contribution to journalArticle

Open Access
File
90 Citations (Scopus)

TAZ Expression as a Prognostic Indicator in Colorectal Cancer

Yuen, H-F., McCrudden, C. M., Huang, Y-H., Tham, J. M., Zhang, X., Zeng, Q., Zhang*, S-D. & Hong*, W., 23 Jan 2013, In : PLoS ONE. 8, 1, p. e54211

Research output: Contribution to journalArticle

Open Access
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