Personal profile
Research Interests
Research in this group focuses on drug delivery/stability and utilises a range of traditional wet chemistry and computational methods.
Sustainable Drug Delivery
A major focus of our work is to employ the twelve principles of green chemistry to improve the sustainability profile of drug delivery methods employing liposomes. Current research focuses on optimising the extraction of phospholipids from Palmaria palmata using biobased-solvents. This involves traditional solubility studies and computational investigations using density functional theory.
Astropharmacy
The stability of drugs in Earth orbit and further out into the solar system is significantly affected by galactic cosmic radiation. This has implications for the safety of astronauts on the International Space Station and any potential missions to Mars. Our research in this area focuses on assessing the radiation stability of drugs and development of novel radioprotective compounds.
Improving Drug Stability with Natural Products
A large number of drugs exhibit photosensitivity which limits their shelf-life. We are currently using the Northern Ireland High Performance Computing facility (Kelvin2) to investigate the use of the indole alkaloid scytonemin in protecting solid dosage forms against UV-induced degredation.
Teaching Interests
Inquiry- and context-based learning is a major feature of undergraduate and postgraduate teaching. Areas of interest include:
- Physical Chemistry
- Pharmaceutics
- Mathematics & Statistics
- Radiopharmacy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 12 Responsible Consumption and Production
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SDG 15 Life on Land
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SDG 17 Partnerships for the Goals
Fingerprint
- 1 Similar Profiles
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Physicochemical Properties of 4-(4-Hydroxyphenyl)-butan-2-one (‘Raspberry Ketone’) Evaluated Using a Computational Chemistry Approach
McPherson, P. A. C., McKenna, N. & Johnston, B. M., 4 Jun 2024, In: ACS Omega. 9, 22, p. 23963-23970 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)150 Downloads (Pure) -
Evaluating theoretical rate constants for bimolecular antioxidant processes involving ionic species under physiological conditions
McPherson, P. A. C., 2 Aug 2024, (Published online) In: Computational and Theoretical Chemistry. 1239, p. 1-5 5 p., 114794.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)48 Downloads (Pure) -
Biphasic Effect of Curcuminoids on Oxidation of Postprandial Chylomicrons
McPherson, P., McKenna, N. & Clare, D., 17 Dec 2021, In: Journal of Medicinal Food. 24, 12, p. 1340-1343 4 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Citation (Scopus) -
Approaches to nonlinear curve fitting in laboratory medicine
McPherson, P. A. C., 1 Aug 2023, (Published online) In: Laboratory Medicine. 55, 2, p. 111-116 6 p., lmad069.Research output: Contribution to journal › Article › peer-review
Open AccessFile96 Downloads (Pure) -
From fungus to pharmaceuticals – the chemistry of statins
McPherson, P., 1 Sept 2012, In: Mini-Reviews in Medicinal Chemistry. 12, 12, p. 1250-1260 11 p.Research output: Contribution to journal › Article › peer-review
8 Link opens in a new tab Citations (Scopus)
Prizes
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JOURNAL OF CHEMICAL EDUCATION (Journal)
McPherson, P. (Reviewer)
2023 → …Activity: Publication peer-review and editorial work › Publication Peer-review
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Regulatory Toxicology and Pharmacology (Journal)
McPherson, P. (Reviewer)
2009Activity: Publication peer-review and editorial work › Publication Peer-review
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Profiles
Projects
- 3 Finished
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Measurement of Marine Phospholipids by a Rapid, Sensitive Electrochemical Method
McPherson, P. (PI) & Coleman, H. (CoI)
1/07/24 → 31/01/26
Project: Research
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Seaweed Forests: Supporting Food & Pharma
McPherson, P. (PI)
Arts and Humanities Research Council
1/05/24 → 30/04/25
Project: Research
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Non-invasive structural tissue analysis for low-cost, highly accurate, safe and rapid cancer diagnosis
Nesbitt, H. (PI), O'Hagan, B. (CoI), Thomas, K. (CoI), Dowey, L. R. (CoI), McCarron, P. (CoI) & McPherson, P. (CoI)
1/07/23 → 30/09/24
Project: Research