• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 2508 Citations
  • 15 h-Index
1989 …2019
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Research Output 1989 2019

  • 2508 Citations
  • 15 h-Index
  • 37 Article
  • 14 Conference contribution
  • 2 Chapter
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Article
2019

Effects of vitamin D as a regulator of androgen intracrinology in LNCAP prostate cancer cells

Cobice, D., Smith, K., Thompson, P., Rodriguez, E. P. & Mackay, L., 12 Nov 2019, In : Biochemical and Biophysical Research Communications. 519, 3, p. 579-584 6 p.

Research output: Contribution to journalArticle

Vitamin D
Androgens
Dehydroepiandrosterone
Prostatic Neoplasms
Cells
Open Access
File
Colitis
Colon
Fibrosis
Inflammation
Dextran Sulfate
2016

A two-stage inference algorithm for gene regulation network models

Mizeranschi, A., Zheng, H., Thompson, P. & Dubitzky, W., 1 Jan 2016, In : International Journal of Computational Biology and Drug Design. 9, 1-2, p. 6-24 19 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Gene expression
Genes
Systems Biology
Particle swarm optimization (PSO)
3 Citations (Scopus)

MultiGrain/MAPPER: A distributed multiscale computing approach to modelling and simulating gene regulation networks.

Mizeranschi, A., Swain, M., SCONA, RALUCA., Fazilleau, Q., Bosak, B., Piontek, T., Kopta, P., Thompson, P. & Werner, D., 1 Oct 2016, In : FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF GRID COMPUTING THEORY METHODS AND APPLICATIONS. 63, p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access
File
Distributed computer systems
Gene expression
Genes
Reverse engineering
Particle swarm optimization (PSO)
2015
1 Citation (Scopus)

Distinct functional modes of SUMOylation for retinoid X receptor alpha

Lee, W-P., Jena, S., Rodriguez, P., O'Donovan, S. P., Wagner, C., Jurutka, P. W. & Thompson, P., 23 Jun 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Open Access
File
Retinoid X Receptor alpha
Sumoylation
Lysine
Protein Inhibitors of Activated STAT
Ubiquitin
1 Citation (Scopus)

Evaluating a common semi-mechanistic mathematical model of gene-regulatory networks

Alexandru, M., Zheng, H., Thompson, P. & Dubitzky, W., 1 Sep 2015, In : BMC Systems Biology 2015. 9(Supp, S2

Research output: Contribution to journalArticle

Open Access
File
Reverse engineering
Genes
Mathematical models
Gene expression
Concretes
2014
7 Citations (Scopus)

Sentrin/SUMO Specific Proteases as Novel Tissue-Selective Modulators of Vitamin D Receptor-Mediated Signaling

Thompson, P., Jena, S., Doherty, D., Lee, WP., Venkatesh, J., Joachim, S., Widener, T., Furmick, J., Lemau, J. & Jurutka, P., Feb 2014, In : PLoS ONE. 9(2), 12 p., e89506.

Research output: Contribution to journalArticle

Open Access
SUMO-1 Protein
Calcitriol Receptors
modifiers (genes)
ubiquitin
Ubiquitin
2013
11 Citations (Scopus)

Vitamin D receptor agonist EB1089 is a potent regulator of prostatic “intracrine” metabolism

Doherty, D., Dvorkin, S. A., Rodriguez, E. P. & Thompson, P., 2013, In : The Prostate. TBC, p. n/a

Research output: Contribution to journalArticle

Open Access
2012
7 Citations (Scopus)

PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor.

Jena, S., Lee, W-P., Doherty, D. & Thompson, P., Oct 2012, In : Journal of Steroid Biochemistry and Molecular Biology. 132, 1-2, p. 24-31

Research output: Contribution to journalArticle

Open Access
File
Calcitriol Receptors
Ubiquitin-Protein Ligases
Protein Inhibitors of Activated STAT
Vitamin D
Sumoylation
20 Citations (Scopus)

Regulation of CYP3A4 and CYP3A5 expression and modulation of “intracrine” metabolism of androgens in prostate cells by liganded vitamin D receptor

Maguire, O., Pollock, C., Martin, P., Owen, A., Smyth, T., Doherty, D., Campbell, M. J., McClean, S. & Thompson, P., 2012, In : Molecular and Cellular Endocrinology. TBC

Research output: Contribution to journalArticle

Open Access
2011
18 Citations (Scopus)

Vitamin D Receptor Gene Variants and Esophageal Adenocarcinoma Risk: A Population-Based Case-Control Study

Chang, C-K., Mulholland, HG., Cantwell, MM., Anderson, LA., Johnston, BT., McKnight, AJ., Thompson, P., Watson, RM. & Murray, LJ., 2011, In : Journal of Gastrointestinal Cancer. Epub a

Research output: Contribution to journalArticle

Open Access
2010
16 Citations (Scopus)

Cytochrome P450 1B1 mRNA Untranslated Regions Interact to Inhibit Protein Translation

Devlin, A., Thompson, P., Robson, T. & McKeown, SR., Feb 2010, In : Molecular Carcinogenesis. 49, 2, p. 190-199

Research output: Contribution to journalArticle

Open Access
Untranslated Regions
Protein Biosynthesis
Cytochrome P-450 Enzyme System
5' Untranslated Regions
Messenger RNA
10 Citations (Scopus)

Effect of Prototypical Inducers on Ligand Activated Nuclear Receptor Regulated Drug Disposition Genes in Rodent Hepatic and Intestinal Cells

Martin, P., Riley, R., Thompson, P., Williams, D., Back, D. & Owen, A., Jan 2010, In : Acta Pharmacologica Sinica. 31, 1, p. 51-65

Research output: Contribution to journalArticle

115 Citations (Scopus)

The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging

Haussler, MR., Haussler, CA., Whitfield, GK., Hsieh, JC., Thompson, P., Barthel, TK., Bartik, L., Egan, JB., Wu, J., Kubicek, JL., Lowmiller, CL., Moffet, EW., Forster, RE. & Jurutka, PW., Jul 2010, In : Journal of Steroid Biochem Mol Biol. 121, 1-2, p. 88-97

Research output: Contribution to journalArticle

2007

Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha

Green, CD., Thompson, P., Johnston, PG. & El-Tanani, MK., 2007, In : Molecular Cancer Research. 5, p. 1191-1200

Research output: Contribution to journalArticle

2005

Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4

Jurutka, PW., Thompson, P., Whitfield, GK., Eichhorst, KR., Hall, N., Dominguez, CE., Hsieh, JC., Haussler, CA. & Haussler, MR., Apr 2005, In : Journal of Cellular Biochemistry. 94, 5, p. 917-943

Research output: Contribution to journalArticle

2003
117 Citations (Scopus)

Identification of FXR as a novel mammalian nuclear receptor sensing lanosterol

Otte, K., Kranz, H., Kober, I., Thompson, P., Hoefer, M., Haubold, B., Remmel, B., Voss, H., Kaiser, C., Albers, M., Cheruvallath, Z., Jackson, D., Casari, G., Koegl, M., Paabo, S., Mous, J., Kremoser, C. & Deuschle, U., 2003, In : Biochemical and Biophysical Research Communications. 23, 3, p. 864-872

Research output: Contribution to journalArticle

15 Citations (Scopus)

Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element.

Hsieh, JC., Whitfield, GK., Jurutka, PW., Haussler, CA., Thatcher, ML., Thompson, P., Dang, HT., Gilligan, MA., Oza, AK. & Haussler, MR., 2003, In : Endocrinology. 144, p. 5065-5080

Research output: Contribution to journalArticle

2002
110 Citations (Scopus)

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements

Thompson, P., Jurutka, PW., Whitfield, G., Myskowski, SM., Eichhorst, KR., Encinas Dominguez, C., Haussler, CA. & Haussler, MR., 2002, In : Biochemical and Biophysical Research Communications. 20, 299, p. 730-738

Research output: Contribution to journalArticle

2001

Distinct Activation Function-2 (AF-2) Residues in RXR Determine Transactivation in the Context of VDR-RXR Heterodimers versus RXR-RXR Homodimers

Thompson, P., Remus, LS., Hsieh, JC., Jurutka, PW., Whitfield, GK., Galligan, MA., Encinas Dominguez, C., Haussler, CA. & Haussler, MR., 2001, In : Journal of Molecular Endocrinology. 27, p. 211-227

Research output: Contribution to journalArticle

Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor

Jurutka, PW., MacDonald, PN., Nakajima, S., Hsieh, JC., Thompson, P., Whitfield, GK., Galligan, MA., Haussler, CA. & Haussler, MR., 2001, In : J. Cell Biochem. 85, p. 435-57

Research output: Contribution to journalArticle

204 Citations (Scopus)

Molecular nature of the vitamin D receptor and its role in regulation of gene expression

Jurutka, PW., Whitfield, GK., Hsieh, JC., Thompson, P., Haussler, CA. & Haussler, MR., 2001, In : Reviews in Endocrine and Metabolic Disorders. 2, 2, p. 203-216

Research output: Contribution to journalArticle

2000
290 Citations (Scopus)

The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB

Jurutka, PW., Remus, LS., Whitfield, GK., Thompson, P., Hsieh, JC., Zitzer, H., Tavokkoli, P., Galligan, MA., Dang, HT., Haussler, CA. & Haussler, MR., 2000, In : Mol Endocrinology. 14, p. 401-420

Research output: Contribution to journalArticle

1999
32 Citations (Scopus)

Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor

Hsieh, JC., Whitfield, GK., Oza, AK., Dang, HT., Price, JN., Galligan, MA., Jurutka, PW., Thompson, P., Haussler, CA. & Haussler, MR., 1999, In : Biochemistry. 38, p. 16347-16358

Research output: Contribution to journalArticle

VDR Binds DNA and Transactivates as a Dimeric Complex with RXR, but not with Thyroid Hormone Receptor (TR)

Thompson, P., Hsieh, JC., Haussler, CA., Whitfield, GK., JB, T., Spindler, SR. & Haussler, MR., 1999, In : J. Cell. Biochem. 75, p. 462-480

Research output: Contribution to journalArticle

1089 Citations (Scopus)

The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed

Haussler, MR., Whitfield, GK., Haussler, CA., Hsieh, JC., Thompson, P., Selznick, SH., Dominguez, CE. & Jurutka, PW., Mar 1998, In : Journal of Bone and Mineral Research. 13, 3, p. 325-349

Research output: Contribution to journalArticle

Open Access
File
1997
Open Access
File
241 Citations (Scopus)

The vitamin D hormone and its nuclear receptor: molecular actions and disease states

Haussler, MR., Haussler, CA., Jurutka, PW., Thompson, P., Hsieh, JC., Remus, LS., Selznick, SH. & Whitfield, GK., 10 Sep 1997, In : Journal of Endrocrinology. 154, p. S57-S73

Research output: Contribution to journalArticle

Open Access
File
1996

Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D-3: Point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner

Whitfield, GK., Selznick, SH., Haussler, CA., Hsieh, JC., Galligan, MA., Jurutka, PW., Thompson, P., Lee, SM., Zerwekh, JE. & Haussler, MR., Dec 1996, In : Molecular Endocrinology. 10, 12, p. 1617-1631

Research output: Contribution to journalArticle

1995

A HIGHLY CONSERVED REGION IN THE HORMONE-BINDING DOMAIN OF THE HUMAN VITAMIN-D-RECEPTOR CONTAINS RESIDUES VITAL FOR HETERODIMERIZATION WITH RETINOID-X-RECEPTOR AND FOR TRANSCRIPTIONAL ACTIVATION

Whitfield, GK., Hsieh, JC., Nakajima, S., Macdonald, PN., Thompson, P., Jurutka, PW., Haussler, CA. & Haussler, MR., Sep 1995, In : Molecular Endocrinology. 9, 9, p. 1166-1179

Research output: Contribution to journalArticle

94 Citations (Scopus)

NEW UNDERSTANDING OF THE MOLECULAR MECHANISM OF RECEPTOR-MEDIATED GENOMIC ACTIONS OF THE VITAMIN-D HORMONE

Haussler, MR., Jurutka, PW., Hsieh, JC., Thompson, P., Selznick, SH., Haussler, CA. & Whitfield, GK., 10 Aug 1995, In : Bone. 17, 2, p. S33-S38

Research output: Contribution to journalArticle

1991
19 Citations (Scopus)

CONVERSION OF ARGININE TO LYSINE AT POSITION 70 OF HUMAN DIHYDROFOLATE-REDUCTASE - GENERATION OF A METHOTREXATE-INSENSITIVE MUTANT ENZYME

Thompson, P. & Freisheim, JH., 6 Aug 1991, In : Biochemistry. 30, 33, p. 8124-8130

Research output: Contribution to journalArticle

1990
18 Citations (Scopus)

ROLE OF LYSINE-54 IN DETERMINING COFACTOR SPECIFICITY AND BINDING IN HUMAN DIHYDROFOLATE-REDUCTASE

Huang, SM., Appleman, JR., Tan, XH., Thompson, P., Blakley, RL., Sheridan, RP., Venkataraghavan, R. & Freisheim, JH., 10 Sep 1990, In : Biochemistry. 29, 35, p. 8063-8069

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)

THE IMPORTANCE OF LOOP REGION RESIDUES 40-46 IN HUMAN DIHYDROFOLATE-REDUCTASE AS REVEALED BY SITE-DIRECTED MUTAGENESIS

Tan, XH., Huang, SM., Ratnam, M., Thompson, P. & Freisheim, JH., 15 May 1990, In : Journal of Biological Chemistry. 265, 14, p. 8027-8032

Research output: Contribution to journalArticle

Open Access
File
1989

MUTAGENESIS OF HUMAN DIHYDROFOLATE-REDUCTASE STRUCTURE AS A PROBE OF ENZYME FUNCTION

Freisheim, JH., Huang, S., Prendergast, NJ., Tan, X., Smith, PL., Bullerjahn, AME., Delcamp, TJ., Thompson, P., Appleman, JR., Beard, WA., Tsay, JT. & Blakley, RL., 1989, NA, p. 708-715

Research output: Contribution to journalArticle