• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 2524 Citations
  • 15 h-Index
1989 …2019

Research output per year

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Personal profile

Biography

Dr Thompson’s lab is interested in deciphering how vitamin D and retinoid derived compounds govern the expression of transcriptional networks important for metabolic function and maintenance of healthy aging and how such effects are mediated through nuclear receptors such as vitamin D receptor (VDR) and retinoid X receptor (RXR)Dr Thompson obtained his PhD in Biochemistry and Molecular Biology from Medical College of Ohio in 1993 after which he joined the laboratory of Prof Mark Haussler (University of Arizona) where he first developed an interest in vitamin D and retinoid biology.From 2002-2003, he worked at LION Bioscience AG (Heidelberg, Germany) where he continued to explore nuclear receptor mechanistic functionality before returning to academia at Ulster.As a Senior Lecturer at Ulster, Dr Thompson is interested in how the vitamin D and retinoid pathways regulate the expression of metabolic gene products and their relevance to endobiotic/drug bioavailability in addition to such diseases as prostate cancer and melanoma.In recent years his lab has been investigating how a process known as SUMOylation may modulate the vitamin D response during periods of chronic disease or in response to inflammatory challenges.At Ulster, Dr Thompson has attracted project funding from Prostate Cancer UK, Prostate Research Campaign UK and the European Union CEC Framework 7.Research InterestsMolecular nutrition and pharmacology of vitamin D and its signal pathway.Nuclear receptor mediated signalling.The Thompson laboratory are keen to hear from motivated students who are interested in PhD studies in this area.Teaching InterestsDr Thompson teaches final year Human Molecular Biology and Genetics as part of the undergraduate degree programmes in Biomedical Sciences and Biology.Administrative RolesDr Thompson is the Postgraduate Tutor for Biomedical Sciences Research Institute at Ulster.

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Research Output

  • 2524 Citations
  • 15 h-Index
  • 37 Article
  • 14 Conference contribution
  • 2 Chapter

Effects of vitamin D as a regulator of androgen intracrinology in LNCAP prostate cancer cells

Cobice, D., Smith, K., Thompson, P., Rodriguez, E. P. & Mackay, L., 12 Nov 2019, In : Biochemical and Biophysical Research Communications. 519, 3, p. 579-584 6 p.

Research output: Contribution to journalArticle

  • Open Access
    File
  • 4 Downloads (Pure)

    A two-stage inference algorithm for gene regulation network models

    Mizeranschi, A., Zheng, H., Thompson, P. & Dubitzky, W., 1 Jan 2016, In : International Journal of Computational Biology and Drug Design. 9, 1-2, p. 6-24 19 p.

    Research output: Contribution to journalArticle

  • MultiGrain/MAPPER: A distributed multiscale computing approach to modelling and simulating gene regulation networks.

    Mizeranschi, A., Swain, M., SCONA, RALUCA., Fazilleau, Q., Bosak, B., Piontek, T., Kopta, P., Thompson, P. & Werner, D., 1 Oct 2016, In : FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF GRID COMPUTING THEORY METHODS AND APPLICATIONS. 63, p. 1-14 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    12 Downloads (Pure)

    Thesis

    Development of Partner Diagnostics and Therapeutics for Genetic Eye Disease

    Author: Chao-Shern, C., Aug 2019

    Supervisor: Nesbit, M. A. (Supervisor), Thompson, P. (Supervisor) & Moore, T. C. B. (Supervisor)

    Student thesis: Doctoral Thesis

    Expression and modulation of the UGT1A family of phase II metabolism genes via liganded vitamin D receptor

    Author: Goodman, R., Sep 2018

    Supervisor: Thompson, P. (Supervisor) & Tambuwala, M. M. (Supervisor)

    Student thesis: Doctoral Thesis

    Inhibition of nuclear factor kappa beta (NF-kβ) as therapeutic strategy for the treatment of IBD and cancer

    Author: Khan, M., 20 Jul 2018

    Supervisor: Tambuwala, M. M. (Supervisor), Mc Carron, P. A. (Supervisor) & Thompson, P. (Supervisor)

    Student thesis: Doctoral Thesis

    File