• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 2469 Citations
  • 15 h-Index
1989 …2019
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Personal profile

Biography

Dr Thompson’s lab is interested in deciphering how vitamin D and retinoid derived compounds govern the expression of transcriptional networks important for metabolic function and maintenance of healthy aging and how such effects are mediated through nuclear receptors such as vitamin D receptor (VDR) and retinoid X receptor (RXR)Dr Thompson obtained his PhD in Biochemistry and Molecular Biology from Medical College of Ohio in 1993 after which he joined the laboratory of Prof Mark Haussler (University of Arizona) where he first developed an interest in vitamin D and retinoid biology.From 2002-2003, he worked at LION Bioscience AG (Heidelberg, Germany) where he continued to explore nuclear receptor mechanistic functionality before returning to academia at Ulster.As a Senior Lecturer at Ulster, Dr Thompson is interested in how the vitamin D and retinoid pathways regulate the expression of metabolic gene products and their relevance to endobiotic/drug bioavailability in addition to such diseases as prostate cancer and melanoma.In recent years his lab has been investigating how a process known as SUMOylation may modulate the vitamin D response during periods of chronic disease or in response to inflammatory challenges.At Ulster, Dr Thompson has attracted project funding from Prostate Cancer UK, Prostate Research Campaign UK and the European Union CEC Framework 7.Research InterestsMolecular nutrition and pharmacology of vitamin D and its signal pathway.Nuclear receptor mediated signalling.The Thompson laboratory are keen to hear from motivated students who are interested in PhD studies in this area.Teaching InterestsDr Thompson teaches final year Human Molecular Biology and Genetics as part of the undergraduate degree programmes in Biomedical Sciences and Biology.Administrative RolesDr Thompson is the Postgraduate Tutor for Biomedical Sciences Research Institute at Ulster.

Fingerprint Dive into the research topics where Paul Thompson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Vitamin D Medicine & Life Sciences
Calcitriol Receptors Medicine & Life Sciences
Sumoylation Medicine & Life Sciences
Gene expression Engineering & Materials Science
Colitis Medicine & Life Sciences
Genes Engineering & Materials Science
SUMO-1 Protein Medicine & Life Sciences
Retinoid X Receptor alpha Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1989 2019

  • 2469 Citations
  • 15 h-Index
  • 37 Article
  • 14 Conference contribution
  • 2 Chapter
Vitamin D
Androgens
Dehydroepiandrosterone
Prostatic Neoplasms
Cells
Open Access
File
Colitis
Colon
Fibrosis
Inflammation
Dextran Sulfate

A two-stage inference algorithm for gene regulation network models

Mizeranschi, A., Zheng, H., Thompson, P. & Dubitzky, W., 1 Jan 2016, In : International Journal of Computational Biology and Drug Design. 9, 1-2, p. 6-24 19 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Gene expression
Genes
Systems Biology
Particle swarm optimization (PSO)
3 Citations (Scopus)

MultiGrain/MAPPER: A distributed multiscale computing approach to modelling and simulating gene regulation networks.

Mizeranschi, A., Swain, M., SCONA, RALUCA., Fazilleau, Q., Bosak, B., Piontek, T., Kopta, P., Thompson, P. & Werner, D., 1 Oct 2016, In : FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF GRID COMPUTING THEORY METHODS AND APPLICATIONS. 63, p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access
File
Distributed computer systems
Gene expression
Genes
Reverse engineering
Particle swarm optimization (PSO)