• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 2666 Citations
  • 28 h-Index
20032019
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Personal profile

Biography

Dr Nigel Irwin holds a BSc Hons in Biomedical Sciences from Ulster University (2001) and a PhD in Experimental Therapeutics for Diabetes also from Ulster (2004). He also has a Diploma in Industrial Studies (2001) and is a Fellow of HEA (2008) as well as being a Research Assistant in Electrophysiology at University of Nevada (2000-2001). Nigel began his career at Ulster as a Research Associate (2004-2007) and a Research Fellow (2007-2009) in Diabetes. He then became a Lecturer in Pharmacology (2009-2014) before being promoted to Senior Lecturer in 2014. He has over 15 years experience in diabetes research with specfic expertise in exploitation of gut-derived peptides for the treatment of diabetes and related disorders. Nigel has published over 150 peer-reviewed publications (h-index 32), presented at numerous national/international conferences and attracted significant external research funding. He is holder of several families of patents for the use of peptide analogues in diabetes-obesity therapy and is the recipient of research awards, and is a member of healthcare science advisory boards as well as engaging in consultant activity. Nigel is a member of several professional societies/committees and has had editorial roles for various respected Journals. Research Interests include: New perspectives on gut peptides for the treatment of diabetes; Synthesis and evaluation of stable gut-derived peptides and hybrid peptides; Pharmacological characterisation of current and novel anti diabetic drugs; Role of incretins in bone strength and quality. Teaching Interests: Pharmacology; Immunology; Biomolecular Therapeutics; Clinical Therapeutics; Drug Discovery; Pharmaceutical Biotechnology; Evidence-based Practice. Administrative Roles: Module Co-ordinator for Clinical Pharmacology and Therapeutics, Cardiovascular, Endocrinal, Renal, Nutrition and Blood, Central Nervous System; Assisstant Diabetes Research Group leader; Senior Radiation Protection Supervisor

Fingerprint Dive into the research topics where Nigel Irwin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 19 Similar Profiles
Glucose Medicine & Life Sciences
Peptides Medicine & Life Sciences
Glucagon-Like Peptide 1 Medicine & Life Sciences
Insulin Medicine & Life Sciences
Hypoglycemic Agents Medicine & Life Sciences
Gastric Inhibitory Polypeptide Medicine & Life Sciences
Fats Medicine & Life Sciences
Obesity Medicine & Life Sciences

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Research Output 2003 2019

  • 2666 Citations
  • 28 h-Index
  • 191 Article
  • 1 Chapter
  • 1 Conference contribution
Open Access
File
Insulin-Secreting Cells
Growth
Dipeptidyl Peptidase 4
Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)-lHRH
peptide YY (1-36)
Peptide Fragments
Islets of Langerhans
Metabolism
Glucose
xenin 25

Short-term CFTR inhibition reduces islet area in C57BL/6 mice

Khan, D., Kelsey, R., Maheshwari, R. R., Stone, V. M., Hasib, A., Manderson Koivula, F., Watson, A., Harkin, S., Irwin, N., Shaw, J. A., McClenaghan, N., Venglovecz, V., Ébert, A., Flodstrom-Tullberg, M., White, M. G. & Kelly, C., 2 Aug 2019, In : Scientific Reports. 9, 1, 11 p., 11244.

Research output: Contribution to journalArticle

Open Access
File
Inbred C57BL Mouse
Insulin
Islets of Langerhans
Cystic Fibrosis
Cell Count

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice

Mansur, S., Mieczkowska, A., Flatt, PR., Chappard, D., Irwin, N. & Mabilleau, G., 19 Feb 2019, 10, 51, 51.

Research output: Contribution to journalArticle

File
Fats
Bone and Bones
High Fat Diet
Collagen
Phosphates
1 Citation (Scopus)
Vasopressin Receptors
Arginine Vasopressin
Insulin-Secreting Cells
Glucose
Survival