• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 1058 Citations
  • 15 h-Index
20092020

Research output per year

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Personal profile

Biography

Dr Murtaza Tambuwala is a Pharmacist and has completed his doctoral research at School of Medicine and Medical Sciences, University College Dublin in 2011 under the tutelage of Prof. Cormac Taylor and Dr Ivan Coulter (CEO of Sublimity Therapeutics); funded by Enterprise Partnership Doctoral Research Award from Irish Research Council. He has undertaken postdoctoral training at Trinity Translational Medicine Institute, Trinity College Dublin under the tutelage of Prof. Padraic Fallon funded by post-doctoral research award obtained from Irish Research Council by Dr Tambuwala.

Dr Tambuwala joined Ulster University as a Lecturer in 2013 to establish his independent research in the field of inflammation and cancer and has published over 70 peer-reviewed manuscripts. The over-arching aims of his research lab are to understand the mechanisms by which hypoxia regulates transcriptional events in inflammation and development of cancer. In particular, he is interested in the regulation of global gene expression in response to hypoxic environment of inflamed adipose tissue/tumour, and the modification of transcriptional regulators which underlies the induction of inflammation, development and progression of cancer. His research is focussed on translating this understanding of hypoxia-sensitive pathways to developing new therapeutics in chronic inflammatory diseases such as IBD, intestinal fibrosis, cardiovascular diseases and colon & breast cancer. 

To achieve the overall objectives of the development of new and better medicines he is working on:

1. Developing novel drug delivery systems to target inflamed tissue and cancer tumours.

2. Investigate the biomolecular mechanism of natural compounds in inflammation and cancer.

3. Use 3D printing technologies to develop personalised oral drug delivery system (Tablets) for IBD patients.

4. Application of 3D bioprinting to develop novel models for IBD, cardiovascular inflammation, colon and breast cancer to reduce the use of animals in research.

Dr Tambuwala initiated and directs the MSc in Pharmaceutical Sciences via Distant learning (Online) at Ulster University and is an active contributor in the delivery and development of MPharm programme at the School of Pharmacy and Pharmaceutical Sciences.

Dr Tambuwala also serves as a reviewer for UK research councils and several esteemed journals in the field of inflammatory bowel diseases and drug delivery.

Education/Academic qualification

PhD, University College Dublin

Bachelor

Master, Trinity College Dublin

External positions

Editorial board Member, Inflammatory Bowel Disease

Editorial Board Member , Inflammopharmacology

Thesis examiner, National University of Ireland Maynooth

Keywords

  • RB Pathology
  • RM Therapeutics. Pharmacology
  • RS Pharmacy and materia medica

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Research Output

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

Tambuwala, M. M., Manresa, M. C., Cummins, E. P., Aversa, V., Coulter, I. S. & Taylor, C., 10 Nov 2015, In : Journal of Controlled Release. 217, p. 221-227 7 p.

Research output: Contribution to journalArticle

  • 38 Citations (Scopus)
    30 Downloads (Pure)

    Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation

    Murphy, A., Thomas, A., Crinion, S., Kent, B., Tambuwala, M., Fabre, A., PEPIN, J-L., Roche, H., ARNAUD, C. & Ryan, S., 19 Apr 2017, In : European Respiratory Journal. 49, p. 1-11 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 38 Citations (Scopus)

    Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon

    Ward, J. B. J., Lajczak, N. K., Kelly, O. B., O'Dwyer, A. M., Giddam, A. K., Ní Gabhainn, J. N., Franco, P., Tambuwala, M. M., Jefferies, C. A., Keely, S., Roda, A. & Keely, S. J., 30 Mar 2017, In : AJP - Gastrointestinal and Liver Physiology. 312, 6, p. G550-G558

    Research output: Contribution to journalArticle

    Open Access
    File
  • 40 Citations (Scopus)
    50 Downloads (Pure)

    REST is a hypoxia-responsive transcriptional repressor

    Cavadas, M. A. S., Mesnieres, M., Crifo, B., Manresa, M. C., Selfridge, A. C., Keogh, C. E., Fabian, Z., Scholz, C. C., Nolan, K. A., Rocha, L. M. A., Tambuwala, M., Brown, S., Wdowicz, A., Corbett, D., Murphy, K. J., Godson, C., Cummins, E. P., Taylor, C. T. & Cheong, A., 17 Aug 2016, In : Scientific Reports. 6, 31355, p. 1-22

    Research output: Contribution to journalArticle

    Open Access
    File
  • 20 Citations (Scopus)
    11 Downloads (Pure)

    Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

    Tambuwala, M., Cummins, E. P., Lenihan, C. R., Kiss, J., Stauch, M., Scholz, C. C., Fraisl, P., Lasitschka, F., Mollenhauer, M., Saunders, S. P., Maxwell, P. H., Carmeliet, P., Fallon, P. G., Schneider, M. & Taylor, C. T., 3 Dec 2010, In : Gastroenterology. 139, 6, p. 2093

    Research output: Contribution to journalArticle

    Open Access
    File
    113 Citations (Scopus)
    9 Downloads (Pure)

    Thesis

    Peptide-loaded, shear sensitive hydrogel as a novel topical delivery system for wound management and repair

    Author: Speers, L., May 2018

    Supervisor: Mc Carron, P. A. (Supervisor), Ternan, N. G. (Supervisor) & Tambuwala, M. M. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Inhibition of nuclear factor kappa beta (NF-kβ) as therapeutic strategy for the treatment of IBD and cancer

    Author: Khan, M., 20 Jul 2018

    Supervisor: Tambuwala, M. M. (Supervisor), Mc Carron, P. A. (Supervisor) & Thompson, P. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Expression and modulation of the UGT1A family of phase II metabolism genes via liganded vitamin D receptor

    Author: Goodman, R., Sep 2018

    Supervisor: Thompson, P. (Supervisor) & Tambuwala, M. M. (Supervisor)

    Student thesis: Doctoral Thesis