Research Output per year
Personal profile
Biography
Dr Murtaza Tambuwala is a Pharmacist and has completed his doctoral research at School of Medicine and Medical Sciences, University College Dublin in 2011 under the tutelage of Prof. Cormac Taylor and Dr Ivan Coulter (CEO of Sublimity Therapeutics); funded by Enterprise Partnership Doctoral Research Award from Irish Research Council. He has undertaken postdoctoral training at Trinity Translational Medicine Institute, Trinity College Dublin under the tutelage of Prof. Padraic Fallon funded by post-doctoral research award obtained from Irish Research Council by Dr Tambuwala.
Dr Tambuwala joined Ulster University as a Lecturer in 2013 and established his independent research in the field of inflammation and cancer. The over-arching aims of his research lab are to understand the mechanisms by which hypoxia regulates transcriptional events in inflammation and development of cancer. In particular, he is interested in the regulation of global gene expression in response to hypoxic environment of inflamed adipose tissue/tumour, and the modification of transcriptional regulators which underlies the induction of inflammation, development and progression of cancer. His research is focussed on translating this understanding of hypoxia-sensitive pathways to developing new therapeutics in chronic inflammatory diseases such as IBD, intestinal fibrosis, cardiovascular diseases and colon & breast cancer.
To achieve the overall objectives of the development of new and better medicines he is working on:
1. Developing novel drug delivery systems to target inflamed tissue and cancer tumours.
2. Investigate the biomolecular mechanism of natural compounds in inflammation and cancer.
3. Use 3D printing technologies to develop personalised oral drug delivery system (Tablets) for IBD patients.
4. Application of 3D bioprinting to develop novel models for IBD, cardiovascular inflammation, colon and breast cancer to reduce the use of animals in research.
Dr Tambuwala initiated and directs the MSc in Pharmaceutical Sciences via Distant learning (Online) at Ulster University and is an active contributor in the delivery and development of MPharm programme at the School of Pharmacy and Pharmaceutical Sciences.
Dr Tambuwala also serves as a reviewer for UK research councils and several esteemed journals in the field of inflammatory bowel diseases and drug delivery.
Education/Academic qualification
PhD, University College Dublin
Bachelor
Master, Trinity College Dublin
External positions
Editorial board Member, Inflammatory Bowel Disease
Editorial Board Member , Inflammopharmacology
Thesis examiner, National University of Ireland Maynooth
Keywords
- RB Pathology
- RM Therapeutics. Pharmacology
- RS Pharmacy and materia medica
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Research Output
Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
Tambuwala, M. M., Manresa, M. C., Cummins, E. P., Aversa, V., Coulter, I. S. & Taylor, C., 10 Nov 2015, In : Journal of Controlled Release. 217, p. 221-227 7 p.Research output: Contribution to journal › Article
35
Citations
(Scopus)
30
Downloads
(Pure)
Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation
Murphy, A., Thomas, A., Crinion, S., Kent, B., Tambuwala, M., Fabre, A., PEPIN, J-L., Roche, H., ARNAUD, C. & Ryan, S., 19 Apr 2017, In : European Respiratory Journal. 49, p. 1-11 11 p.Research output: Contribution to journal › Article
Open Access
34
Citations
(Scopus)
Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon
Ward, J. B. J., Lajczak, N. K., Kelly, O. B., O'Dwyer, A. M., Giddam, A. K., Ní Gabhainn, J. N., Franco, P., Tambuwala, M. M., Jefferies, C. A., Keely, S., Roda, A. & Keely, S. J., 30 Mar 2017, In : AJP - Gastrointestinal and Liver Physiology. 312, 6, p. G550-G558Research output: Contribution to journal › Article
Open Access
File
34
Citations
(Scopus)
20
Downloads
(Pure)
REST is a hypoxia-responsive transcriptional repressor
Cavadas, M. A. S., Mesnieres, M., Crifo, B., Manresa, M. C., Selfridge, A. C., Keogh, C. E., Fabian, Z., Scholz, C. C., Nolan, K. A., Rocha, L. M. A., Tambuwala, M., Brown, S., Wdowicz, A., Corbett, D., Murphy, K. J., Godson, C., Cummins, E. P., Taylor, C. T. & Cheong, A., 17 Aug 2016, In : Scientific Reports. 6, 31355, p. 1-22Research output: Contribution to journal › Article
Open Access
File
19
Citations
(Scopus)
9
Downloads
(Pure)
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
Tambuwala, M., Cummins, E. P., Lenihan, C. R., Kiss, J., Stauch, M., Scholz, C. C., Fraisl, P., Lasitschka, F., Mollenhauer, M., Saunders, S. P., Maxwell, P. H., Carmeliet, P., Fallon, P. G., Schneider, M. & Taylor, C. T., 3 Dec 2010, In : Gastroenterology. 139, 6, p. 2093Research output: Contribution to journal › Article
Open Access
File
111
Citations
(Scopus)
9
Downloads
(Pure)
Thesis
Expression and modulation of the UGT1A family of phase II metabolism genes via liganded vitamin D receptor
Author: Goodman, R., Sep 2018Supervisor: Thompson, P. (Supervisor) & Tambuwala, M. M. (Supervisor)
Student thesis: Doctoral Thesis
Inhibition of nuclear factor kappa beta (NF-kβ) as therapeutic strategy for the treatment of IBD and cancer
Author: Khan, M., 20 Jul 2018Supervisor: Tambuwala, M. M. (Supervisor), Mc Carron, P. A. (Supervisor) & Thompson, P. (Supervisor)
Student thesis: Doctoral Thesis
File
Peptide-loaded, shear sensitive hydrogel as a novel topical delivery system for wound management and repair
Author: Speers, L., May 2018Supervisor: Mc Carron, P. A. (Supervisor), Ternan, N. G. (Supervisor) & Tambuwala, M. M. (Supervisor)
Student thesis: Doctoral Thesis