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Michael Conlon

Prof

1991 …2019
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Research Output 1991 2019

2019
Lampreys
Glucagon-Like Peptide 1
Homeostasis
Fats
Glucose

Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs

Scorciapino, MA., Carta, P., Pantic, JM., Lukic, M. L., Lukic, A., Musale, V., Abdel-Wahab, Y. & Conlon, JM., 19 Oct 2019, In : Biochimie. p. xx x.

Research output: Contribution to journalArticle

Anura
Skin
Insulin
Peptides
Arginine

Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin-TR from the Trinidanian leaf frog Phyllomedusa trinitatis.

Pantic, J., Guilhaudis, L., Musale, V., Attoub, S., Lukic, M. L., Mechkarska, M. & Conlon, JM., 31 Aug 2019, In : Journal of Peptide Science. e3153, 4, p. 1-10 10 p., e3153.

Research output: Contribution to journalArticle

frogs
peptides
interleukin-10
leaves
tumor necrosis factor-alpha

Insights into conformation and membrane interactions of the acyclic and dicarba‑bridged brevinin‑1BYa antimicrobial peptides

Timmons, PB., O'Flynn, D., Conlon, JM. & Hewage, C., 13 Aug 2019, (Accepted/In press) In : EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 48, 8, p. 701-710 10 p.

Research output: Contribution to journalArticle

Conformations
Membranes
Peptides
Micelles
Trifluoroethanol

Structural and positional studies of the antimicrobial peptide brevinin-1BYa in membrane-mimetic environments

Timmons, PB., O'Flynn, D., Conlon, JM. & Hewage, C., 12 Jul 2019, (Accepted/In press) In : Journal of Peptide Science. 25, 11, e3208.

Research output: Contribution to journalArticle

Membranes
Micelles
Peptides
Hinges
Sodium Dodecyl Sulfate
2018
3 Citations (Scopus)

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti‐diabetic agents

Musale, V., Casciaro, B., Mangoni, LM., Abdel-Wahab, YHA., Flatt, P. & Conlon, JM., 19 Jan 2018, In : Journal of Peptide Science. 24, p. e3065

Research output: Contribution to journalArticle

Open Access
Rana temporaria
Ranidae
Anura
Peptides
Insulin
Open Access
File
Glucagon Receptors
Glucagon-Like Peptide 1
Lampreys
Fishes
Peptides
2 Citations (Scopus)
Open Access
File
Medical problems
Glucagon
Fish
Type 2 Diabetes Mellitus
Fishes
5 Citations (Scopus)

Identification of Components in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents

Conlon, JM., Moffett, C., Leprince, J. & Flatt, P., 24 Feb 2018, In : Methods in Molecular Biology. 1719, p. 319-333

Research output: Contribution to journalArticle

Open Access
Hypoglycemic Agents
Skin
Peptides
Insulin
Glucose
2 Citations (Scopus)

Insulinotropic, glucose-lowering, and beta-cell anti-apoptotic actions of peptides related to esculentin-1a(1-21).NH2

Musale, V., Abdel-Wahab, YHA., Flatt, P., Conlon, J. M. & Mangoni, M. L., 7 Mar 2018, (Accepted/In press) In : Amino Acids. 50, 6, p. 723-724

Research output: Contribution to journalArticle

Open Access
Glucose
Peptides
Type 2 Diabetes Mellitus
Body Weight
Insulin
1 Citation (Scopus)

Insulinotropic activity of the host-defense peptide frenatin 2D: conformational, structure-function and mechanistic studies

Musale, V., Guilhaudis, L., Abdel-Wahab, Y., Flatt, PR. & Conlon, JM., 19 Sep 2018, In : Biochimie. 156, p. 12-21 9 p.

Research output: Contribution to journalArticle

Open Access
File
Peptides
Insulin
Down-Regulation
KATP Channels
Cytoprotection

Peptidomic analysis of the host-defense peptides in skin secretions of Rana graecaprovidesinsightintophylogeneticrelationshipsamongEurasianRana species

Mechkarska, M., Kolodziejek, J., Musale, V., Coquet, L., Leprince, J., Jouenne, T., Nowotny, N. & Conlon, JM., 27 Dec 2018, In : Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 29, p. 228 234 p., Part D 29.

Research output: Contribution to journalArticle

Ranidae
Skin
Peptides
Anura
Melitten
1 Citation (Scopus)

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae)

Mechkarska, M., Coquet, L., Leprince, J., Auguste, R., Jouenn, T. & Conlon, JM., 30 Jun 2018, In : Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. xx, xx, p. xx 8 p., xx.

Research output: Contribution to journalArticle

Open Access
File
Anura
Skin
Peptides
Tarsiidae
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
2 Citations (Scopus)

Towards establishing a higher acceptance rate for PEPTIDES - the peer review process and criteria for acceptance or rejection

Conlon, JM. & Herzig, K-H., 28 Nov 2018, In : Peptides. 112, p. 32 33 p.

Research output: Contribution to journalArticle

Peer Review
Publications
Screening
Manuscripts
Rejection (Psychology)
2017
8 Citations (Scopus)

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents

Owolabi, BO., Musalea, V., Ojo, OO., Moffett, C., McGahon, MK., Curtis, TM., Conlon, JM., Flatt, P. & Abdel-Wahab, YHA., 7 Apr 2017, In : Biochimie. 138, p. 1-12

Research output: Contribution to journalArticle

Open Access
File
Pipidae
Insulin
Peptides
Anura
Therapeutics
5 Citations (Scopus)

Anti-diabetic actions of esculentin-2CHa(1–30) and its stable analogues in a diet-induced model of obesity-diabetes

Vasu, S., Ojo, O., Moffett, C., Conlon, JM., Flatt, P. & Abdel-Wahab, Y., 23 Aug 2017, In : Amino Acids. 49, 10, p. 1705-1717

Research output: Contribution to journalArticle

Open Access
Obesity
Diet
Peptides
High Fat Diet
Blood Glucose
6 Citations (Scopus)

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae)

Conlon, JM., Musale, V., Attoub, S., Mangoni, ML., Leprince, J., Coquet, L., Jouenne, T., Abdel-Wahab, YHA., Flatt, P. & Rinaldi, AC., 11 Jul 2017, In : Journal of Peptide Science. 23, 10, p. 769-776

Research output: Contribution to journalArticle

Open Access
Ranidae
Anura
Insulin
Skin
Peptides
8 Citations (Scopus)

Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action.

Vasu, S., McGahon, M., Moffett, C., Curtis, T., Conlon, JM., Abdel-Wahab, YHA. & Flatt, P., 1 Mar 2017, In : Journal of Endrocrinology. 232, 3, p. 423-435

Research output: Contribution to journalArticle

Open Access
File
Insulin
KATP Channels
Cell Membrane
Diazoxide
Glucose
7 Citations (Scopus)
Open Access
Zebrafish
Insulin
Glucose
Insulin-Secreting Cells
Islets of Langerhans
13 Citations (Scopus)

Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy

Conlon, JM., Mechkarska, M., Abdel-Wahab, YHA. & Flatt, P., 2 Sep 2017, (Accepted/In press) In : Peptides. 100, p. 275-281

Research output: Contribution to journalArticle

Open Access
Medical problems
Anura
Type 2 Diabetes Mellitus
Skin
Insulin
3 Citations (Scopus)
Open Access
Pipidae
Proline
Anura
Arginine
Skin
1 Citation (Scopus)

The activity of the rectal gland of the North Pacific spiny dogfish Squalus suckleyi is glucose dependent and stimulated by glucagon-like peptide-1.

Deck, CA., Anderson, WG., Conlon, JM. & Walsh, PJ., 25 Apr 2017, In : Journal of Comparative Physiology B. 187, 8, p. 1155-1161

Research output: Contribution to journalArticle

Open Access
File
Squalus
glucagon-like peptide 1
Squalus acanthias
glucose
symporters
3 Citations (Scopus)

The Frog Skin Host-Defense Peptide Frenatin 2.1S Enhances Recruitment, Activation and Tumoricidal Capacity of NK Cells

Pantic, JM., Jovanovica, IP., Radosavljevica, GD., Gajovic, NM., Arsenijevic, NN., Conlon, JM. & Lukic, ML., 16 May 2017, In : Peptides. 93, p. 44-50

Research output: Contribution to journalArticle

Open Access
T-cells
Natural Killer Cells
Anura
Skin
Chemical activation
13 Citations (Scopus)

The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents

Pantic, JM., Jovanovic, IP., Radosavljevic, GD., Arsenijevic, NN., Conlon, JM. & Lukic, ML., 13 Dec 2017, In : Molecules. 22, 12, p. E2071-E2071

Research output: Contribution to journalArticle

Open Access
Anura
Skin
Peptides
Cytokines
Interleukin-23
2016
5 Citations (Scopus)
Open Access
Adiposity
Insulin-Secreting Cells
Insulin Resistance
Triglycerides
Fats
13 Citations (Scopus)
Open Access
File
Dogfish
Obese Mice
Glucagon
Hyperglycemia
Insulin
7 Citations (Scopus)
Open Access
File
Glucose Intolerance
Insulin Resistance
Insulin
Diet
Glucose
17 Citations (Scopus)

In vitro and in vivo insulinotropic properties of the multifunctional frog skin peptide hymenochirin-1B: a structure-activity study.

Owolabi, BO., Ojo, OO., Srinivasan, DK., Flatt, P., Conlon, JM. & Abdel-Wahab, Y., 1 Feb 2016, In : Amino Acids. 48, 2, p. 535-547

Research output: Contribution to journalArticle

Open Access
Skin
Insulin
Peptides
Cytotoxicity
Lysine
13 Citations (Scopus)

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

Ojo, OO., Srinivasan, DK., Owolabi, BO., McGahon, MK., Moffett, C., Curtis, TM., Conlon, JM., Flatt, P. & Abdel-Wahab, Y., 1 Aug 2016, In : Biological Chemistry. 397, 8, p. 753-764

Research output: Contribution to journalArticle

Open Access
Nutrition
Insulin Resistance
Obesity
Insulin
Diet
11 Citations (Scopus)
Open Access
File
Dogfish
Glucagon
Hypoglycemic Agents
Insulin
Glucose
1 Citation (Scopus)

Peptidomic analysis of the extensive array of host-defense peptides in skin secretions of the dodecaploid frog Xenopus ruwenzoriensis (Pipidae)

Coqueta, L., Kolodziejek, J., Jouenne, T., Nowotny, N., King, JD. & Conlon, JM., 25 Aug 2016, In : Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 19C, p. 18-24

Research output: Contribution to journalArticle

Open Access
File
Pipidae
Xenopus
Anura
Skin
Peptides
7 Citations (Scopus)

Purification, Conformational Analysis, and Properties of a Family ofTigerinin Peptides from Skin Secretions of the Crowned BullfrogHoplobatrachus occipitalis

McLaughlin, CM., Lampis, S., Mechkarska, M., Coquet, L., Jouenne, T., King, JD., Mangoni, ML., Lukic, ML., Scorciapino, MA. & Conlon, J. M., 25 Aug 2016, In : Journal of Natural Products. N/A, p. 1-7

Research output: Contribution to journalArticle

Open Access
File
Skin
Peptides
Interferon-gamma
Enteroendocrine Cells
Rana catesbeiana
2015
5 Citations (Scopus)

Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities

Manzo, G., Scorciapino, MA., Srinivasan, D., Attoub, S., Mangoni, ML., Flatt, P. & Conlon, JM., 24 Dec 2015, In : Journal of Natural Products. 78, 12, p. 3041-3048

Research output: Contribution to journalArticle

Open Access
Toxicity
Insulin
Peptides
Cells
Trifluoroethanol
8 Citations (Scopus)

Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance.

Ojo, O., Srinivasan, DK., Owolabi, BO., Vasu, S., Conlon, J. M., Flatt, P. & Abdel-Wahab, Y., 29 Oct 2015, In : PLoS ONE. 10, 10, p. e0141549-e0141549

Research output: Contribution to journalArticle

Open Access
Islets of Langerhans
Insulin Resistance
Obesity
Diet
Glucose
7 Citations (Scopus)
Open Access
Anura
Insulin Resistance
Fats
Insulin
Lipids
2014
16 Citations (Scopus)

A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)

Conlon, J. M., Mechkarska, M., Radosavljevic, G., Attoub, S., King, J. D., Lukic, M. L. & McClean, S., 2014, In : Peptides. 56, 0, p. 132 - 140

Research output: Contribution to journalArticle

Open Access
Anura
Cytokines
Skin
Peptides
Lipopolysaccharides
19 Citations (Scopus)

Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study

Srinivasan, D., Ojo, O., Abdel-Wahab, Y., Flatt, P., Guilhaudis, L. & Conlon, JM., 12 Feb 2014, In : Peptides. 55, p. 23-31

Research output: Contribution to journalArticle

Amino Acid Substitution
Cytotoxicity
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Tryptophan
12 Citations (Scopus)

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

Ojo, O., Srinivasan, DK., Owolabi, BO., Conlon, JM., Flatt, P. & Abdel-Wahab, Y., 20 Oct 2014, In : Biochim Biophys Acta. 1850, 1, p. 80-87

Research output: Contribution to journalArticle

Open Access
Magainins
Homeostasis
Fats
Glucose
Insulin
90 Citations (Scopus)
Anura
Skin
Peptides
Neoplasms
Therapeutics
2013
26 Citations (Scopus)
Open Access
Ceruletide
Peptide Fragments
Xenopus laevis
Skin
Insulin
22 Citations (Scopus)
Open Access
Magainins
Glucagon-Like Peptide 1
Anura
Pipidae
Skin
13 Citations (Scopus)
Open Access
Anura
Insulin
Skin
Peptides
Lysine

Insulin-Releasing Peptides

Ojo, OO., Flatt, P., Abdel-Wahab, Y. & Conlon, JM., 2013, Handbook of Biologically Active Peptides (2nd Edition). Elsevier, p. 364-370

Research output: Chapter in Book/Report/Conference proceedingChapter

2011
18 Citations (Scopus)
Open Access
xenopsin
Ceruletide
Skin
Insulin
Peptides
25 Citations (Scopus)

Peptidomic analysis of skin secretions from the bullfrog Lithobates catesbeianus (Ranidae) identifies multiple peptides with potent insulin-releasing activity

Mechkarska, M., Ojo, O. O., Meetani, M. A., Coquet, L., Jouenne, T., Abdel-Wahab, Y., Flatt, P., King, J. D. & Conlon, J. M., Feb 2011, In : Peptides. 32, 2, p. 203-208

Research output: Contribution to journalArticle

Open Access
Ranidae
Lithobates catesbeianus
insulin
secretion
peptides
31 Citations (Scopus)
Open Access
Anura
Insulin
Skin
Peptides
Glucose
2010
24 Citations (Scopus)
trypsinogen activation peptide
High Fat Diet
Insulin
Glucose
Peptides
Open Access
2009
25 Citations (Scopus)

A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae)

Conlon, J. M., Abdel-Wahab, Y., Flatt, P., Leprince, J., Vaudry, H., Jouenne, T. & Condamine, E., May 2009, In : Peptides. 30, 5, p. 888-892

Research output: Contribution to journalArticle

Open Access
glycine (amino acid)
skin (animal)
leucine
frogs
secretion