John Michael Conlon

Weinrauch, A. M., Bouyoucos, I. A., Conlon, J. M. & Anderson, W. G., 1 May 2024, In: General and Comparative Endocrinology. 350, p. 1-11 11 p., 114470.

Research output: Contribution to journal › Article › peer-review

2023

Antimicrobial, cytotoxic and insulin‐releasing activities of the amphibian host‐defense peptide ocellatin‐3N and its L‐lysine‐substituted analogs

Conlon, J. M., Hunter, L., Attoub, S., Casciaro, B., Mechkarska, M. & Abdel‐Wahab, Y. H. A., 30 Apr 2023, In: Journal of Peptide Science. 29, 4, p. e3463 10 p., e3463.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

20 Downloads (Pure)

An update on peptide-based therapies for type 2 diabetes and obesity

Bailey, C. J., Flatt, P. R. & Conlon, J. M., 31 Mar 2023, In: Peptides. 161, p. 170939 6 p., 170939.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

49 Citations (Scopus)

517 Downloads (Pure)

Identification of an Antimicrobial Peptide from the Venom of the Trinidad Thick-Tailed Scorpion Tityus trinitatis with Potent Activity against ESKAPE Pathogens and Clostridioides difficile

Mechkarska, M., Cunning, T., Taggart, M., Ternan, N. G., Leprince, J., Coquet, L., Jouenne, T., Tena-Garcés, J., Calvete, J. & Conlon, J., 4 Sept 2023, (Published online) In: Antibiotics. 12, 9, p. 1-13 13 p., 1404.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

12 Downloads (Pure)

Peptidomic analysis of the host-defense peptides in skin secretions of the Amazon River frog Lithobates palmipes (Ranidae)

Mechkarska, M., Barran, G., Kolodziejek, J., Coquet, L., Leprince, J., Jouenne, T., Nowotny, N. & Conlon, J. M., 30 Jun 2023, In: Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 46, p. 101069 101069.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

71 Downloads (Pure)

Purification, Conformational Analysis and Cytotoxic Activities of Host-Defense Peptides from the Giant Gladiator Treefrog Boana boans (Hylidae: Hylinae)

Conlon, J. M., Guilhaudis, L., Attoub, S., Coquet, L., Leprince, J., Jouenne, T. & Mechkarska, M., 25 Jun 2023, (Published online) In: Antibiotics. 12, 7, p. 1-14 14 p., 1102.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

31 Downloads (Pure)

Purification, conformational analysis and cytotoxic activities of host-defense peptides from the Tungara frog Engystomops pustulosus (Leptodactylidae; Leiuperinae)

Conlon, J. M., Guilhaudis, L., Attoub, S., Coquet, L., Leprince, J., Jouenne, T. & Mechkarska, M., Oct 2023, In: Amino Acids. 55, 10, p. 1349-1359 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

20 Downloads (Pure)

2022

Alpha-cells and therapy of diabetes: inhibition, antagonism or death?

Klempel, N., Thomas, K., Conlon, J., Flatt, P. & Irwin, N., 1 Nov 2022, In: Peptides. 157, 8 p., 170877.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

65 Downloads (Pure)

Dual-agonist incretin peptides from fish with potential for obesity-related Type 2 diabetes therapy – a review

Conlon, J., O'Harte, F. & Flatt, P., 1 Jan 2022, In: Peptides. 147, p. 170706 10 p., 170706.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

8 Citations (Scopus)

62 Downloads (Pure)

Publishing in PEPTIDES - a 2022 update.

Conlon, J. & Herzig , K.-H., 31 Jul 2022, Peptides, 153, p. 170812.

Research output: Contribution to specialist publication › Editorial

Open Access

File

14 Downloads (Pure)

Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides

Conlon, J. M., 31 Dec 2022, In: Peptides. 158, 170896.

Research output: Contribution to journal › Editorial › peer-review

2021

Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: a mechanistic study

Musale, V., Moffett, C., Conlon, J., Flatt, P. & Abdel-Wahab, Y., 28 Feb 2021, In: Peptides. 136, p. 170472 170472.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

16 Downloads (Pure)

Conformational change following conversion of inactive rhinophrynin-33 to bioactive rhinophrynin-27 in the skin of the frog Rhinophrynus dorsalis

Carta, P., Conlon, J. & Scorciapino, M., 28 Feb 2021, In: Biochimie. 181, p. 162-168 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

9 Downloads (Pure)

Effects of long‐acting analogues of lamprey GLP‐1 and paddlefish glucagon on alpha‐ to beta‐cell transdifferentiation in an insulin‐deficient transgenic mouse model

Graham, G., Conlon, J., Moffett, C., Abdel-Wahab, Y. & Flatt, P., Aug 2021, In: Journal of Peptide Science. 27, 8, p. e3328 7 p., e3328.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

25 Downloads (Pure)

Recent advances in peptide-based therapy for Type 2 diabetes and obesity

Conlon, J., Flatt, P. & Bailey, C., Nov 2021, Peptides, 145, 170652, p. 170652.

Research output: Contribution to specialist publication › Editorial

Open Access

File

1 Citation (Scopus)

12 Downloads (Pure)

The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective

Conlon, J., 11 Jun 2021, In: Frontiers in Endocrinology. 12, p. 683089 683089.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

2 Citations (Scopus)

70 Downloads (Pure)

2020

A long-acting, dual-agonist analogue of lamprey GLP-1 shows potent insulinotropic, β-cell protective, and anorexic activities and improves glucose homeostasis in high fat-fed mice

Graham, G., Mc Closkey, A., Abdel-Wahab, Y., Conlon, J. & Flatt, P., 1 Jan 2020, In: Molecular and Cellular Endocrinology. 499, 110584.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

32 Downloads (Pure)

Editorial: GIP renaissance

Flatt, P. & Conlon, J., 31 Mar 2020, In: Peptides. 125, 170266.

Research output: Contribution to journal › Editorial › peer-review

Open Access

File

3 Citations (Scopus)

13 Downloads (Pure)

Editorial: Highlights from selected articles in the journal involving host-defense peptides

Conlon, J., 18 Oct 2020, (Accepted/In press) Peptides, 134.

Research output: Contribution to specialist publication › Editorial

Open Access

File

11 Downloads (Pure)

Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities

Graham, G., Conlon, J., Abdel-Wahab, Y. & Flatt, P., 5 Jul 2020, In: European Journal of Pharmacology. 878, 13 p., 173101.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

182 Downloads (Pure)

Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae)

Conlon, J., Attoub, S., Musale, V., Leprince, J., Casewell, N., Sanz, L. & Calvete, J., 30 Jun 2020, In: Toxicon. 6, 8 p., 100030.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

139 Downloads (Pure)

Mechanisms of action of the anti-diabetic peptide [S4K]CPF-AM1 in db/db mice

Musale, V., Moffett, C., Owolabi, B., Conlon, J., Flatt, P. & Abdel-Wahab, Y., 1 Nov 2020, (Published online) In: Journal of Molecular Endocrinology. 66, 2, p. 115-128 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (Scopus)

21 Downloads (Pure)

Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity

Barran, G., Kolodziejek, J., Coquet, L., Leprince, J., Jouenne, T., Nowotny, N., Conlon, J. & Mechkarska, M., 20 Oct 2020, In: Antibiotics. 9, 10, p. 1-15 15 p., 718.

Research output: Contribution to journal › Article › peer-review

Open Access

File

13 Citations (Scopus)

80 Downloads (Pure)

Selection of antimicrobial frog peptides and temporin-1DRa analogues for treatment of bacterial infections based on their cytotoxicity and differential activity against pathogens

Gaiser, R. A., Ayerra Mangado, J., Mechkarska, M., Kaman, W. E., van Baarlen, P., Conlon, J. M. & Wells, J. M., 29 Nov 2020, In: Chemical Biology and Drug Design. 96, 4, p. 1103-1113 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Strategies for improving stability and pharmacokinetic characteristics of radiolabeled peptides for imaging and therapy

Gharibkandi, N., Conlon, J. & Hosseinimehr, S., 1 Nov 2020, In: Peptides. 133, 18 p., 170385.

Research output: Contribution to journal › Article › peer-review

Open Access

File

29 Citations (Scopus)

43 Downloads (Pure)

2019

Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs

Scorciapino, M., Carta, P., Pantic, J., Lukic, M. L., Lukic, A., Musale, V., Abdel-Wahab, Y. & Conlon, J., 31 Dec 2019, In: Biochimie. 167, p. 198-206 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

139 Downloads (Pure)

Glucagon-like peptides-1 from phylogenetically ancient fish show potent anti-diabetic activities by acting as dual GLP1R and GCGR agonists

Graham, G. V., Conlon, M., Abdel-Wahab, Y. H. & Flatt, P., 15 Jan 2019, In: Molecular and Cellular Endocrinology. 480, p. 54-64 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

54 Downloads (Pure)

Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin-TR from the Trinidanian leaf frog Phyllomedusa trinitatis.

Pantic, J., Guilhaudis, L., Musale, V., Attoub, S., Lukic, M. L., Mechkarska, M. & Conlon, J., 31 Aug 2019, In: Journal of Peptide Science. e3153, 4, p. 1-10 10 p., e3153.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

17 Downloads (Pure)

Insights into conformation and membrane interactions of the acyclic and dicarba‑bridged brevinin‑1BYa antimicrobial peptides

Timmons, P., O'Flynn, D., Conlon, J. & Hewage, C., 13 Aug 2019, (Accepted/In press) In: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 48, 8, p. 701-710 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

14 Downloads (Pure)

Peptidomic analysis in the discovery of therapeutically valuable peptides in amphibian skin secretions

Conlon, J., Mechkarska, M. & Leprince, J., 11 Nov 2019, (Accepted/In press) In: Expert Review of Proteomics. 16, 11-12, p. 897-908

Research output: Contribution to journal › Article › peer-review

Open Access

File

36 Citations (Scopus)

45 Downloads (Pure)

Structural and positional studies of the antimicrobial peptide brevinin-1BYa in membrane-mimetic environments

Timmons, P., O'Flynn, D., Conlon, J. & Hewage, C., 12 Nov 2019, In: Journal of Peptide Science. 25, 11, e3208.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

20 Downloads (Pure)

2018

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti‐diabetic agents

Musale, V., Casciaro, B., Mangoni, L., Abdel-Wahab, Y., Flatt, P. & Conlon, J., 19 Jan 2018, (Published online) In: Journal of Peptide Science. 24, p. e3065

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Editorial: Newer peptide-based agents for treatment of patients with Type 2 diabetes

Flatt, P. R. & Conlon, J. M., Feb 2018, In: Peptides. 100, p. 1-2 2 p.

Research output: Contribution to journal › Editorial › peer-review

7 Citations (Scopus)

Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy

Graham, G., Conlon, J., Abdel-Wahab, Y. & Flatt, P., 31 Dec 2018, In: Peptides. 110, p. 19-29 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

14 Citations (Scopus)

29 Downloads (Pure)

Identification of Components in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents

Conlon, J., Moffett, C., Leprince, J. & Flatt, P., 24 Feb 2018, (Published online) In: Methods in Molecular Biology. 1719, p. 319-333

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Insulinotropic, glucose-lowering, and beta-cell anti-apoptotic actions of peptides related to esculentin-1a(1-21).NH2

Musale, V., Abdel-Wahab, Y., Flatt, P., Conlon, J. M. & Mangoni, M. L., 7 Mar 2018, (Accepted/In press) In: Amino Acids. 50, 6, p. 723-724

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Insulinotropic activity of the host-defense peptide frenatin 2D: conformational, structure-function and mechanistic studies

Musale, V., Guilhaudis, L., Abdel-Wahab, Y., Flatt, P. & Conlon, J., 19 Sept 2018, (Published online) In: Biochimie. 156, p. 12-21 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

30 Downloads (Pure)

Peptidomic analysis of the host-defense peptides in skin secretions of Rana graeca provides insight into phylogenetic relationships among Eurasian Rana species

Mechkarska, M., Kolodziejek, J., Musale, V., Coquet, L., Leprince, J., Jouenne, T., Nowotny, N. & Conlon, J., 27 Dec 2018, In: Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 29, p. 228 234 p., Part D 29.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

28 Downloads (Pure)

Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae)

Mechkarska, M., Coquet, L., Leprince, J., Auguste, R., Jouenn, T. & Conlon, J., 30 Jun 2018, (Published online) In: Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 28, p. 72-79

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

61 Downloads (Pure)

Towards establishing a higher acceptance rate for PEPTIDES - the peer review process and criteria for acceptance or rejection

Conlon, J. & Herzig , K.-H., 28 Nov 2018, In: Peptides. 112, p. 32 33 p.

Research output: Contribution to journal › Article › peer-review

File

4 Citations (Scopus)

22 Downloads (Pure)

2017

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents

Owolabi, B., Musalea, V., Ojo, O., Moffett, C., McGahon, M., Curtis, T., Conlon, J., Flatt, P. & Abdel-Wahab, Y., 7 Apr 2017, (Published online) In: Biochimie. 138, p. 1-12

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

83 Downloads (Pure)

Anti-diabetic actions of esculentin-2CHa(1–30) and its stable analogues in a diet-induced model of obesity-diabetes

Vasu, S., Ojo, O., Moffett, C., Conlon, J., Flatt, P. & Abdel-Wahab, Y., 23 Aug 2017, (Published online) In: Amino Acids. 49, 10, p. 1705-1717

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae)

Conlon, J., Musale, V., Attoub, S., Mangoni, M., Leprince, J., Coquet, L., Jouenne, T., Abdel-Wahab, Y., Flatt, P. & Rinaldi, A., 11 Jul 2017, (Published online) In: Journal of Peptide Science. 23, 10, p. 769-776

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Esculentin-2CHa(1–30) and its analogues: stability and mechanisms of insulinotropic action

Vasu, S., McGahon, M., Moffett, C., Curtis, T., Conlon, J., Abdel-Wahab, Y. & Flatt, P., 1 Mar 2017, In: Journal of Endrocrinology. 232, 3, p. 423-435 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

64 Downloads (Pure)

Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor.

Graham, G., Conlon, J., Abdel-Wahab, Y., Gault, V. A. & Flatt, P., 20 Nov 2017, (Published online) In: Peptides. 100, p. 182-189

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

John Michael Conlon

Research output

Search results