• Cromore Road, Coleraine Campus

    BT52 1SA Coleraine

    United Kingdom

  • 3387 Citations
  • 35 h-Index
1994 …2020

Research output per year

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Research Output

  • 3387 Citations
  • 35 h-Index
  • 200 Article
  • 4 Conference contribution
2020

Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Harnedy-Rothwell, PA., McLaughlin, C., O’Keeffe, MB., Le Gouic, AV., Allsopp, P. J., McSorley, E. M., Sharkey, S., Whooley, J., McGovern, B., O'Harte, F. & Fitzgerald, RJ., 1 May 2020, In : Food Research International. 131, 108989.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Stability to thermal treatment of dipeptidyl peptidase IV (DPP-IV) inhibitory activity of a boarfish (Capros aper) protein hydrolysate when incorporated into tomato-based products

Harnedy-Rothwell, PA., McLaughlin, C., Crowe, W., Allsopp, P. J., McSorley, E. M., Devaney, M., Whooley, J., McGovern, B., V, P., O'Harte, F. & Fitzgerald, R., 1 May 2020, (Accepted/In press) In : International Journal of Food Science and Technology. xx, xx, p. xx xx.

Research output: Contribution to journalArticle

2019
1 Citation (Scopus)
2018

Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions

O'Harte, F., Parthsarathy, V., Hogg, C. & Flatt, P., 3 Feb 2018, In : Peptides. 100, p. 219-228

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

Harnedy, PA., Parthsarathy, V., McLaughlin, CM., O’Keeffe, MB., Allsopp, P., McSorley, E. M., O'Harte, F. & FitzGerald, RG., 6 Feb 2018, In : Food Research International. 106, p. 598-606 8 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties

Harnedy, PA., Parthsarathy, V., McLaughlin, CM., O'Keeffe, MB., Allsopp, P., McSorley, E. M., O'Harte, F. & Fitzgerald, RJ., Jan 2018, In : Journal of Functional Foods. 40, p. 137-145 8 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP-1 secretory activity in vitro and acute glucose lowering effects in mice.

V, P., McLaughlin, C., Harnedy, PA., Allsopp, P. J., Crowe, W., Mc Sorley, E., Fitzgerald, R. & O'Harte, F., 10 Sep 2018, (Accepted/In press) In : International Journal of Food Science and Technology. 54, p. 271-278 281 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
25 Downloads (Pure)

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

O'Harte, F., V, P., Hogg, C. & Flatt, PR., 29 Aug 2018, In : PLoS ONE. 13, 8, e0202350.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
9 Downloads (Pure)
2017

Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties

O'Harte, F., Parthsarathy, V., Hogg, C. & Flatt, P., 15 Dec 2017, In : Biochemical Pharmacology. 146, p. 165-173 9 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)

Beneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic mice.

Parthsarathy, V., Hogg, C., Flatt, P. & O'Harte, F., 22 Aug 2017, In : Diabetes Obesity and Metabolism. 20, 2, p. 319-327 9 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2016

Development of novel ligands for peptide GPCRs

Moran, BM., McKillop, A. & O'Harte, F., 1 Dec 2016, In : Current Opinion in Pharmacology. 31, p. 57-62

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
17 Citations (Scopus)
11 Downloads (Pure)

Glucagon receptor antagonist and GIP agonist combination for diet induced obese mice.

McShane, L., Irwin, N., O'Flynn, D., Franklin, Z., Hewage, C. & O'Harte, F., 1 Jun 2016, In : Journal of Endrocrinology. 229, p. 319-330

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
13 Citations (Scopus)
6 Downloads (Pure)
2014

Ablation of glucagon receptor signaling by peptide-based glucagon antagonists improves glucose tolerance in high fat fed mice.

Franklin, ZJ., McShane, LM., O'Harte, F. & Irwin, N., 18 Aug 2014, In : Peptides. 60, p. 95-101

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Ablation of glucagon receptor signaling by peptide-based glucagon antagonists improves glucose tolerance in high fat fed mice.

McShane, LM., Franklin, ZJ., O'Harte, F. & Irwin, N., 18 Aug 2014, In : Peptides. 60, p. 95-101

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
Open Access
15 Citations (Scopus)
Open Access
6 Citations (Scopus)
13 Citations (Scopus)
Open Access
14 Citations (Scopus)
2013
Open Access
11 Citations (Scopus)

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

O'Harte, F., Franklin, ZJ., Rafferty, EP. & Irwin, N., 5 Dec 2013, In : Molecular and Cellular Endocrinology. 381, 1-2, p. 26-34

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
Open Access
10 Citations (Scopus)
Open Access
13 Citations (Scopus)
2012

Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes

Irwin, N., Frizelle, P., Montgomery, IA., Moffett, RC., O'Harte, F. & Flatt, P., 20 Jul 2012, In : Diabetologia. 55, 10, p. 2747-2758

Research output: Contribution to journalArticle

41 Citations (Scopus)
Open Access
10 Citations (Scopus)
2011

Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Bell, P., Cuthbertson, J., Patterson, S. & O'Harte, F., 1 Mar 2011, In : Diabetes Research and Clinical Practice. 91, p. E68-E70

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide.

Venneti, KC., Malthouse, JP., O'Harte, F. & Hewage, CM., 1 Jul 2011, In : Biochim Biophys Acta.. 1814, 7, p. 882-888

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

(Pro(3))glucagon-amide acts as a glucagon receptor antagonist in cultured cells and in obese diabetic ob/ob mice

O'Harte, F., Rafferty, E. P., Franklin, Z. & Irwin, N., Nov 2010, In : IRISH JOURNAL OF MEDICAL SCIENCE. 179, 13, p. 507

Research output: Contribution to journalArticle

Peptide based glucagon analogues are effective agents in blocking the hyperglycaemic actions of glucagon in high fat fed mice

Franklin, Z., Rafferty, EP., Irwin, N. & O'Harte, F., Sep 2010, In : Regulatory Peptides. 164, 1, Sp., p. 32-33

Research output: Contribution to journalArticle

Open Access

Stability and efficacy studies in N-terminally truncated glucagon receptor antagonist peptides

Rafferty, EP., Franklin, Z., Irwin, N. & O'Harte, F., Sep 2010, In : Regulatory Peptides. 164, 1, Sp., p. 41-42

Research output: Contribution to journalArticle

Open Access

The novel (Pro(3)) glucagon-amide analogue antagonises the action of glucagon both in vitro and in vivo

O'Harte, F., Franklin, Z., Rafferty, EP. & Irwin, N., Sep 2010, In : Regulatory Peptides. 164, 1, Sp., p. 42

Research output: Contribution to journalArticle

Open Access
2009
Open Access
35 Citations (Scopus)
Open Access
12 Citations (Scopus)

Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Cuthbertson, J., Patterson, S., O'Harte, FPM. & Bell, PM., Jun 2009, In : Diabetic medicine. 26, 6, p. 649-654

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)

Structure function studies with glucagon related peptides reveal glucagon receptor antagonist activities in vitro and in vivo

O'Harte, FPM., McClean, PL. & Irwin, N., Sep 2009, Unknown Host Publication. p. 565 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2008

Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects

McKillop, A., Duffy, N. A., Lindsay, J. R., O'Harte, F., Bell, P. M. & Flatt, P., Jan 2008, In : Diabetes Research and Clinical Practice. 79, 1, p. 79-85

Research output: Contribution to journalArticle

Open Access
38 Citations (Scopus)

Metformin combined with exogenous glucagon-like peptide-1 gives added benefit by improving acute glycaemic control in type 2 diabetic subjects

Cuthbertson, J., Patterson, S., O'Harte, FPM. & Bell, PM., 8 Sep 2008, Unknown Host Publication. p. 943 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2007
Open Access
11 Citations (Scopus)

Characterisation and biological activity of Glu(3) amino acid substituted GIP receptor antagonists

Gault, V., Hunter, K., Irwin, N., Green, B. D., Greer, B., Harriott, P., O'Harte, F. & Flatt, P., May 2007, In : Archives of Biochemistry and Biophysics. 461, 2, p. 263-274

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro(3))GIP receptor antagonist in type 2 diabetes

Gault, V., Hunter, K., Irwin, N., Greer, B., Green, B. D., Harriott, P., O'Harte, F. & Flatt, P., Feb 2007, In : Biological Chemistry. 388, 2, p. 173-179

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
Open Access
21 Citations (Scopus)